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Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice
Open accessAbstract
Osteopetrotic (op/op) mice lack functional M-CSF and have depressed levels of macrophages and osteoclasts. We prepared transgenic mice (hMRP8bcl-2) that express human Bcl-2 in monocytes. In vitro hMRP8bcl-2 monocytes do not undergo apoptosis in the absence of serum and M-CSF, while op/op and wild-type monocytes die. These Bcl-2-expressing monocytes spontaneously undergo macrophage differentiation. In vivo, the op/op hMRP8bcl-2 mice show significant replenishment of tissue macrophages. Their long bone osteopetrosis is largely reversed, and extensive medullary hematopoiesis appears in the bone marrow. We propose that M-CSF augments monocyte survival, permitting them to respond to internal and external cues for their differentiation.
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Metadata
- Authors
- Lagasse, E., & Weissman, I. L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 89
- Issue
- 7
- Pages
- 1021-1031
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2065577210
- Cited by
- 288
- References
- 2
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice. https://app.cochat.ai/papers/10.1016/s0092-8674(00)80290-1
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- Lagasse, E., & Weissman, I. L. (1997). Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice. Cell. https://doi.org/10.1016/s0092-8674(00)80290-1
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