Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

Toll-like receptor signalling

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Osteoclast differentiation and activation

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

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Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

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The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation

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Osteoblastic cells regulate the haematopoietic stem cell niche

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

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Identification of the haematopoietic stem cell niche and control of the niche size

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Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

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Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

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A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.

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Bone Quality — The Material and Structural Basis of Bone Strength and Fragility

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Transcriptional regulation by calcium, calcineurin, and NFAT

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Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.

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The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

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Genetic regulation of osteoclast development and function

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IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

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Reaching a Genetic and Molecular Understanding of Skeletal Development

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Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

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Control of osteoblast function and regulation of bone mass

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TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

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The molecular understanding of osteoclast differentiation

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T-Cell mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ.

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NFAT Signaling

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint

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Denosumab in postmenopausal women with low bone mineral density.

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Ubiquitin signalling in the NF-κB pathway

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TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells

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Requirement for NF-κB in osteoclast and B-cell development

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Osteopetrosis in mice lacking NF-κB1 and NF-κB2

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DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells

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Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

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Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

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Bone versus immune system

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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

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RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution

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TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.

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Cellular Niches Controlling B Lymphocyte Behavior within Bone Marrow during Development

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Regulation of cancer cell migration and bone metastasis by RANKL.

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Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.

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Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

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Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

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Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability

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The osteoclast differentiation factor osteoprotegerin ligand is essential for mammary gland development.

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OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism

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RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β

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Evidence for the Secretion of an Osteoclast Stimulating Factor in Myeloma

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Interleukin 6: from bench to bedside

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Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

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TRANCE, a TNF Family Member, Activates Akt/PKB through a Signaling Complex Involving TRAF6 and c-Src

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Anti-TNF-α therapies: the next generation

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Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos

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Fos/AP‐1 proteins in bone and the immune system

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Osteopetrosis in mice lacking haematopoietic transcription factor PU.1

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Osteoclasts are essential for TNF-α–mediated joint destruction

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NFAT and Osterix cooperatively regulate bone formation

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Osteoclasts are essential for TNF-α-mediated joint destruction.

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Segregation of TRAF6‐mediated signaling pathways clarifies its role in osteoclastogenesis

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The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor

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The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase

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Essential Role of p38 Mitogen-activated Protein Kinase in Cathepsin K Gene Expression during Osteoclastogenesis through Association of NFATc1 and PU.1

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NFATc1 and NFATc2 Together Control Both T and B Cell Activation and Differentiation

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Activated T Lymphocytes Support Osteoclast Formation in Vitro

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Mechanistic insight into osteoclast differentiation in osteoimmunology

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Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells

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Osteoclast differentiation independent of the TRANCE–RANK–TRAF6 axis

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RANKL-induced DC-STAMP Is Essential for Osteoclastogenesis

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Calcineurin/NFAT Signaling in Osteoblasts Regulates Bone Mass

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Regulation of osteoclast differentiation and function by the CaMK-CREB pathway

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TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivo

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Pancreatic Lymph Node-Derived CD4+CD25+ Treg Cells

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Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-γ-induced class II transactivator

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αvβ3and macrophage colony‐stimulating factor: partners in osteoclast biology

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Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice

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Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiationPreprint

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The IκB Function of NF-κB2 p100 Controls Stimulated Osteoclastogenesis

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A Novel Member of the Leukocyte Receptor Complex Regulates Osteoclast Differentiation

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