The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane
Open accessAbstract
Previous models for signal transduction via the Notch pathway have depicted the full-length Notch receptor expressed at the cell surface. We present evidence demonstrating that the Notch receptor on the plasma membrane is cleaved. This cleavage is an evolutionarily conserved, general property of Notch and occurs in the trans-Golgi network as the receptor traffics toward the plasma membrane. Although full-length Notch is detectable in the cell, it does not reach the surface. Cleavage results in a C-terminal fragment, N(TM), that appears to be cleaved N-terminal to the transmembrane domain, and an N-terminal fragment, N(EC), that contains most of the extracellular region. We provide evidence that these fragments are tethered together on the plasma membrane by a link that is sensitive to reducing conditions, forming a heterodimeric receptor.
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Citations
Cites
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cécillion, M., Maréchal, E., et al. (1996) · Nature · doi:10.1038/383707a0 · Cited by 2,068
Cited by
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
Self-citationA presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) · Nature · doi:10.1038/19083 · Cited by 2,100
A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1
Mumm, J. S., Schroeter, E. H., Saxena, M. T., Griesemer, A., Tian, X., Pan, D. J., Ray, W. J., & Kopan, R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80416-5 · Cited by 853
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
Ohtsuka, T., Ishibashi, M., Gradwohl, G., Nakanishi, S., Guillemot, F., & Kageyama, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.8.2196 · Cited by 852
Nuclear Access and Action of Notch In Vivo
Struhl, G., & Adachi, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81193-9 · Cited by 733
Metadata
- Authors
- Blaumueller, C. M., Qi, H., Zagouras, P., & Artavanis-Tsakonas, S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 90
- Issue
- 2
- Pages
- 281-291
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2061738087
- Cited by
- 614
- References
- 1
- FWCI
- 13.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Blaumueller, C. M., Qi, H., Zagouras, P., & Artavanis-Tsakonas, S. (1997). Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane. Cell. https://doi.org/10.1016/s0092-8674(00)80336-0
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