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Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

Ohtsuka, Toshiyuki, Ishibashi, Makoto, Gradwohl, Gérald, Nakanishi, Shigetada, Guillemot, François, Kageyama, Ryoichiro·1999·The EMBO Journal
DOI 10.1093/emboj/18.8.2196
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  • Negative regulation of Hes5 promotes neuronal differentiation.

    “the negative regulation of which has also been found to promote neuronal differentiation in other studies (Ohtsuka et al., 1999; Fig. 7 I, K ).”

    From Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes (2013) · cites this paper as Ohtsuka et al., 1999

    The indexed Abstract reports that activated Notch inhibited neuronal differentiation in Hes5-null cells, but not in cells lacking both Hes1 and Hes5. This supports a role for Hes5 alongside Hes1, not the claim that negative regulation of Hes5 alone promotes neuronal differentiation. (LLM, conf=0.85)

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  1. Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R. A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J Biol Chem. 1995 Apr 14;270(15):8730–8738. doi: 10.1074/jbc.270.15.8730. [DOI] [PubMed] [Google Scholar] · DOI
  2. Akazawa C., Sasai Y., Nakanishi S., Kageyama R. Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. J Biol Chem. 1992 Oct 25;267(30):21879–21885. [PubMed] [Google Scholar]
  3. Artavanis-Tsakonas S., Matsuno K., Fortini M. E. Notch signaling. Science. 1995 Apr 14;268(5208):225–232. doi: 10.1126/science.7716513. [DOI] [PubMed] [Google Scholar] · DOI
  4. Bao Z. Z., Cepko C. L. The expression and function of Notch pathway genes in the developing rat eye. J Neurosci. 1997 Feb 15;17(4):1425–1434. doi: 10.1523/JNEUROSCI.17-04-01425.1997. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  5. Ben-Arie N., Bellen H. J., Armstrong D. L., McCall A. E., Gordadze P. R., Guo Q., Matzuk M. M., Zoghbi H. Y. Math1 is essential for genesis of cerebellar granule neurons. Nature. 1997 Nov 13;390(6656):169–172. doi: 10.1038/36579. [DOI] [PubMed] [Google Scholar] · DOI
  6. Blaumueller C. M., Qi H., Zagouras P., Artavanis-Tsakonas S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell. 1997 Jul 25;90(2):281–291. doi: 10.1016/s0092-8674(00)80336-0. [DOI] [PubMed] [Google Scholar] · DOI
  7. Capobianco A. J., Zagouras P., Blaumueller C. M., Artavanis-Tsakonas S., Bishop J. M. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol. 1997 Nov;17(11):6265–6273. doi: 10.1128/mcb.17.11.6265. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  8. Casarosa S., Fode C., Guillemot F. Mash1 regulates neurogenesis in the ventral telencephalon. Development. 1999 Feb;126(3):525–534. doi: 10.1242/dev.126.3.525. [DOI] [PubMed] [Google Scholar] · DOI
  9. Cau E., Gradwohl G., Fode C., Guillemot F. Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. Development. 1997 Apr;124(8):1611–1621. doi: 10.1242/dev.124.8.1611. [DOI] [PubMed] [Google Scholar] · DOI
  10. Chen H., Thiagalingam A., Chopra H., Borges M. W., Feder J. N., Nelkin B. D., Baylin S. B., Ball D. W. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5355–5360. doi: 10.1073/pnas.94.10.5355. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  11. Conlon R. A., Reaume A. G., Rossant J. Notch1 is required for the coordinate segmentation of somites. Development. 1995 May;121(5):1533–1545. doi: 10.1242/dev.121.5.1533. [DOI] [PubMed] [Google Scholar] · DOI
  12. Dorsky R. I., Chang W. S., Rapaport D. H., Harris W. A. Regulation of neuronal diversity in the Xenopus retina by Delta signalling. Nature. 1997 Jan 2;385(6611):67–70. doi: 10.1038/385067a0. [DOI] [PubMed] [Google Scholar] · DOI
  13. Ellisen L. W., Bird J., West D. C., Soreng A. L., Reynolds T. C., Smith S. D., Sklar J. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 1991 Aug 23;66(4):649–661. doi: 10.1016/0092-8674(91)90111-b. [DOI] [PubMed] [Google Scholar] · DOI
  14. Fode C., Gradwohl G., Morin X., Dierich A., LeMeur M., Goridis C., Guillemot F. The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron. 1998 Mar;20(3):483–494. doi: 10.1016/s0896-6273(00)80989-7. [DOI] [PubMed] [Google Scholar] · DOI
  15. Gridley T. Notch signaling in vertebrate development and disease. Mol Cell Neurosci. 1997;9(2):103–108. doi: 10.1006/mcne.1997.0610. [DOI] [PubMed] [Google Scholar] · DOI
  16. Guillemot F., Lo L. C., Johnson J. E., Auerbach A., Anderson D. J., Joyner A. L. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell. 1993 Nov 5;75(3):463–476. doi: 10.1016/0092-8674(93)90381-y. [DOI] [PubMed] [Google Scholar] · DOI
  17. Honjo T. The shortest path from the surface to the nucleus: RBP-J kappa/Su(H) transcription factor. Genes Cells. 1996 Jan;1(1):1–9. doi: 10.1046/j.1365-2443.1996.10010.x. [DOI] [PubMed] [Google Scholar] · DOI
  18. Hrabe de Angelis M., McIntyre J., 2nd, Gossler A. Maintenance of somite borders in mice requires the Delta homologue DII1. Nature. 1997 Apr 17;386(6626):717–721. doi: 10.1038/386717a0. [DOI] [PubMed] [Google Scholar] · DOI
  19. Hsieh J. J., Nofziger D. E., Weinmaster G., Hayward S. D. Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation. J Virol. 1997 Mar;71(3):1938–1945. doi: 10.1128/jvi.71.3.1938-1945.1997. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  20. Ishibashi M., Ang S. L., Shiota K., Nakanishi S., Kageyama R., Guillemot F. Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 1995 Dec 15;9(24):3136–3148. doi: 10.1101/gad.9.24.3136. [DOI] [PubMed] [Google Scholar] · DOI
  21. Ishibashi M., Moriyoshi K., Sasai Y., Shiota K., Nakanishi S., Kageyama R. Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system. EMBO J. 1994 Apr 15;13(8):1799–1805. doi: 10.1002/j.1460-2075.1994.tb06448.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  22. Issack P. S., Ziff E. B. Genetic elements regulating HES-1 induction in Wnt-1-transformed PC12 cells. Cell Growth Differ. 1998 Oct;9(10):827–836. [PubMed] [Google Scholar]
  23. Jarriault S., Brou C., Logeat F., Schroeter E. H., Kopan R., Israel A. Signalling downstream of activated mammalian Notch. Nature. 1995 Sep 28;377(6547):355–358. doi: 10.1038/377355a0. [DOI] [PubMed] [Google Scholar] · DOI
  24. Jarriault S., Le Bail O., Hirsinger E., Pourquié O., Logeat F., Strong C. F., Brou C., Seidah N. G., Isra l A. Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol. 1998 Dec;18(12):7423–7431. doi: 10.1128/mcb.18.12.7423. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  25. Jhappan C., Gallahan D., Stahle C., Chu E., Smith G. H., Merlino G., Callahan R. Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev. 1992 Mar;6(3):345–355. doi: 10.1101/gad.6.3.345. [DOI] [PubMed] [Google Scholar] · DOI
  26. Joutel A., Corpechot C., Ducros A., Vahedi K., Chabriat H., Mouton P., Alamowitch S., Domenga V., Cécillion M., Marechal E. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature. 1996 Oct 24;383(6602):707–710. doi: 10.1038/383707a0. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  27. Kageyama R., Nakanishi S. Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system. Curr Opin Genet Dev. 1997 Oct;7(5):659–665. doi: 10.1016/s0959-437x(97)80014-7. [DOI] [PubMed] [Google Scholar] · DOI
  28. Kopan R., Nye J. S., Weintraub H. The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development. 1994 Sep;120(9):2385–2396. doi: 10.1242/dev.120.9.2385. [DOI] [PubMed] [Google Scholar] · DOI
  29. Kopan R., Schroeter E. H., Weintraub H., Nye J. S. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1683–1688. doi: 10.1073/pnas.93.4.1683. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  30. Lecourtois M., Schweisguth F. Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos. Curr Biol. 1998 Jun 18;8(13):771–774. doi: 10.1016/s0960-9822(98)70300-8. [DOI] [PubMed] [Google Scholar] · DOI
  31. Lewis J. Neurogenic genes and vertebrate neurogenesis. Curr Opin Neurobiol. 1996 Feb;6(1):3–10. doi: 10.1016/s0959-4388(96)80002-x. [DOI] [PubMed] [Google Scholar] · DOI
  32. Luo B., Aster J. C., Hasserjian R. P., Kuo F., Sklar J. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol. 1997 Oct;17(10):6057–6067. doi: 10.1128/mcb.17.10.6057. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  33. Ma Q., Chen Z., del Barco Barrantes I., de la Pompa J. L., Anderson D. J. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron. 1998 Mar;20(3):469–482. doi: 10.1016/s0896-6273(00)80988-5. [DOI] [PubMed] [Google Scholar] · DOI
  34. Matsuno K., Eastman D., Mitsiades T., Quinn A. M., Carcanciu M. L., Ordentlich P., Kadesch T., Artavanis-Tsakonas S. Human deltex is a conserved regulator of Notch signalling. Nat Genet. 1998 May;19(1):74–78. doi: 10.1038/ng0598-74. [DOI] [PubMed] [Google Scholar] · DOI
  35. Milner L. A., Bigas A., Kopan R., Brashem-Stein C., Bernstein I. D., Martin D. I. Inhibition of granulocytic differentiation by mNotch1. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13014–13019. doi: 10.1073/pnas.93.23.13014. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  36. Nishimura M., Isaka F., Ishibashi M., Tomita K., Tsuda H., Nakanishi S., Kageyama R. Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split. Genomics. 1998 Apr 1;49(1):69–75. doi: 10.1006/geno.1998.5213. [DOI] [PubMed] [Google Scholar] · DOI
  37. Nye J. S., Kopan R., Axel R. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development. 1994 Sep;120(9):2421–2430. doi: 10.1242/dev.120.9.2421. [DOI] [PubMed] [Google Scholar] · DOI
  38. Ordentlich P., Lin A., Shen C. P., Blaumueller C., Matsuno K., Artavanis-Tsakonas S., Kadesch T. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol. 1998 Apr;18(4):2230–2239. doi: 10.1128/mcb.18.4.2230. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  39. Pan D., Rubin G. M. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell. 1997 Jul 25;90(2):271–280. doi: 10.1016/s0092-8674(00)80335-9. [DOI] [PubMed] [Google Scholar] · DOI
  40. Pear W. S., Aster J. C., Scott M. L., Hasserjian R. P., Soffer B., Sklar J., Baltimore D. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med. 1996 May 1;183(5):2283–2291. doi: 10.1084/jem.183.5.2283. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  41. Robey E., Chang D., Itano A., Cado D., Alexander H., Lans D., Weinmaster G., Salmon P. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell. 1996 Nov 1;87(3):483–492. doi: 10.1016/s0092-8674(00)81368-9. [DOI] [PubMed] [Google Scholar] · DOI
  42. Sasai Y., Kageyama R., Tagawa Y., Shigemoto R., Nakanishi S. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 1992 Dec;6(12B):2620–2634. doi: 10.1101/gad.6.12b.2620. [DOI] [PubMed] [Google Scholar] · DOI
  43. Schroeter E. H., Kisslinger J. A., Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. 1998 May 28;393(6683):382–386. doi: 10.1038/30756. [DOI] [PubMed] [Google Scholar] · DOI
  44. Shawber C., Nofziger D., Hsieh J. J., Lindsell C., Bögler O., Hayward D., Weinmaster G. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development. 1996 Dec;122(12):3765–3773. doi: 10.1242/dev.122.12.3765. [DOI] [PubMed] [Google Scholar] · DOI
  45. Sommer L., Shah N., Rao M., Anderson D. J. The cellular function of MASH1 in autonomic neurogenesis. Neuron. 1995 Dec;15(6):1245–1258. doi: 10.1016/0896-6273(95)90005-5. [DOI] [PubMed] [Google Scholar] · DOI
  46. Sparrow J. R., Hicks D., Barnstable C. J. Cell commitment and differentiation in explants of embryonic rat neural retina. Comparison with the developmental potential of dissociated retina. Brain Res Dev Brain Res. 1990 Jan 1;51(1):69–84. doi: 10.1016/0165-3806(90)90259-2. [DOI] [PubMed] [Google Scholar] · DOI
  47. Struhl G., Adachi A. Nuclear access and action of notch in vivo. Cell. 1998 May 15;93(4):649–660. doi: 10.1016/s0092-8674(00)81193-9. [DOI] [PubMed] [Google Scholar] · DOI
  48. Swiatek P. J., Lindsell C. E., del Amo F. F., Weinmaster G., Gridley T. Notch1 is essential for postimplantation development in mice. Genes Dev. 1994 Mar 15;8(6):707–719. doi: 10.1101/gad.8.6.707. [DOI] [PubMed] [Google Scholar] · DOI
  49. Takebayashi K., Akazawa C., Nakanishi S., Kageyama R. Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element. J Biol Chem. 1995 Jan 20;270(3):1342–1349. doi: 10.1074/jbc.270.3.1342. [DOI] [PubMed] [Google Scholar] · DOI
  50. Takebayashi K., Sasai Y., Sakai Y., Watanabe T., Nakanishi S., Kageyama R. Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements. J Biol Chem. 1994 Feb 18;269(7):5150–5156. [PubMed] [Google Scholar]
  51. Tamura K., Taniguchi Y., Minoguchi S., Sakai T., Tun T., Furukawa T., Honjo T. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol. 1995 Dec 1;5(12):1416–1423. doi: 10.1016/s0960-9822(95)00279-x. [DOI] [PubMed] [Google Scholar] · DOI
  52. Tomita K., Ishibashi M., Nakahara K., Ang S. L., Nakanishi S., Guillemot F., Kageyama R. Mammalian hairy and Enhancer of split homolog 1 regulates differentiation of retinal neurons and is essential for eye morphogenesis. Neuron. 1996 Apr;16(4):723–734. doi: 10.1016/s0896-6273(00)80093-8. [DOI] [PubMed] [Google Scholar] · DOI
  53. Tomita K., Nakanishi S., Guillemot F., Kageyama R. Mash1 promotes neuronal differentiation in the retina. Genes Cells. 1996 Aug;1(8):765–774. doi: 10.1111/j.1365-2443.1996.tb00016.x. [DOI] [PubMed] [Google Scholar] · DOI
  54. Tsuda H., Takebayashi K., Nakanishi S., Kageyama R. Structure and promoter analysis of Math3 gene, a mouse homolog of Drosophila proneural gene atonal. Neural-specific expression by dual promoter elements. J Biol Chem. 1998 Mar 13;273(11):6327–6333. doi: 10.1074/jbc.273.11.6327. [DOI] [PubMed] [Google Scholar] · DOI
  55. Turner D. L., Cepko C. L. A common progenitor for neurons and glia persists in rat retina late in development. Nature. 1987 Jul 9;328(6126):131–136. doi: 10.1038/328131a0. [DOI] [PubMed] [Google Scholar] · DOI
  56. Wang S., Sdrulla A. D., diSibio G., Bush G., Nofziger D., Hicks C., Weinmaster G., Barres B. A. Notch receptor activation inhibits oligodendrocyte differentiation. Neuron. 1998 Jul;21(1):63–75. doi: 10.1016/s0896-6273(00)80515-2. [DOI] [PubMed] [Google Scholar] · DOI
  57. Weinmaster G. The ins and outs of notch signaling. Mol Cell Neurosci. 1997;9(2):91–102. doi: 10.1006/mcne.1997.0612. [DOI] [PubMed] [Google Scholar] · DOI
  58. Yoshimatsu T., Tamura M., Kuriyama S., Ikenaka K. Improvement of retroviral packaging cell lines by introducing the polyomavirus early region. Hum Gene Ther. 1998 Jan 20;9(2):161–172. doi: 10.1089/hum.1998.9.2-161. [DOI] [PubMed] [Google Scholar] · DOI
  59. de la Pompa J. L., Wakeham A., Correia K. M., Samper E., Brown S., Aguilera R. J., Nakano T., Honjo T., Mak T. W., Rossant J. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development. 1997 Mar;124(6):1139–1148. doi: 10.1242/dev.124.6.1139. [DOI] [PubMed] [Google Scholar] · DOI

Cited by

Sorted by citations

Authors
Ohtsuka, T., Ishibashi, M., Gradwohl, G., Nakanishi, S., Guillemot, F., & Kageyama, R.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
1999-04-15
Volume
18
Issue
8
Pages
2196-2207
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.1093/emboj/18.8.2196
Cited by
735
References
0
Language
en
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