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Nuclear Translocation of Extradenticle Requires , which Encodes an Extradenticle-Related Homeodomain Protein
Open accessAbstract
We show that homothorax (hth) is required for the Hox genes to pattern the body of the fruit fly, Drosophila melanogaster. hth is necessary for the nuclear localization of an essential HOX cofactor, Extradenticle (EXD), and encodes a homeodomain protein that shares extensive identity with the product of Meis1, a murine proto-oncogene. MEIS1 is able to rescue hth mutant phenotypes and can induce the cytoplasmic-to-nuclear translocation of EXD in cell culture and Drosophila embryos. Thus, Meis1 is a murine homolog of hth. MEIS1/HTH also specifically binds to EXD with high affinity in vitro. These data suggest a novel and evolutionarily conserved mechanism for regulating HOX activity in which a direct protein-protein interaction between EXD and HTH results in EXD's nuclear translocation.
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Feinstein, P. G., Kornfeld, K., Hogness, D. S., & Mann, R. S. (1995) · Genetics · doi:10.1093/genetics/140.2.573 · Cited by 122
Self-citation
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Kroon, E., Krosl, J., Thorsteinsdottir, U., Baban, S., Buchberg, A. M., & Sauvageau, G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3714 · Cited by 640
Low Affinity Binding Site Clusters Confer Hox Specificity and Regulatory Robustness
Crocker, J., Abe, N., Rinaldi, L., McGregor, A. P., Frankel, N., Wang, S., Alsawadi, A., Valenti, P., Plaza, S., Payre, F., et al. (2015) · Cell · doi:10.1016/j.cell.2014.11.041 · Cited by 363
Self-citationDefining Roles for HOX and MEIS1 Genes in Induction of Acute Myeloid Leukemia
Thorsteinsdottir, U., Kroon, E., Jerome, L., Blasi, F., & Sauvageau, G. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.224-234.2001 · Cited by 284
Bellaoui, M., Pidkowich, M. S., Samach, A., Kushalappa, K., Kohalmi, S. E., Modrusan, Z., Crosby, W. L., & Haughn, G. W. (2001) · The Plant Cell · doi:10.1105/tpc.010161 · Cited by 232
Metadata
- Authors
- Rieckhof, G. E., Casares, F., Ryoo, H. D., Abu-Shaar, M., & Mann, R. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 91
- Issue
- 2
- Pages
- 171-183
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1998020029
- Cited by
- 435
- References
- 1
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Nuclear Translocation of Extradenticle Requires , which Encodes an Extradenticle-Related Homeodomain Protein. https://app.cochat.ai/papers/10.1016/s0092-8674(00)80400-6
- The paper
- Rieckhof, G. E., Casares, F., Ryoo, H. D., Abu-Shaar, M., & Mann, R. S. (1997). Nuclear Translocation of Extradenticle Requires , which Encodes an Extradenticle-Related Homeodomain Protein. Cell. https://doi.org/10.1016/s0092-8674(00)80400-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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