The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Defining Roles for HOX and MEIS1 Genes in Induction of Acute Myeloid Leukemia
Open accessAbstract
Complex genetic and biochemical interactions between HOX proteins and members of the TALE (i.e., PBX and MEIS) family have been identified in embryonic development, and some of these interactions also appear to be important for leukemic transformation. We have previously shown that HOXA9 collaborates with MEIS1 in the induction of acute myeloid leukemia (AML). In this report, we demonstrate that HOXB3, which is highly divergent from HOXA9, also genetically interacts with MEIS1, but not with PBX1, in generating AML. In addition, we show that the HOXA9 and HOXB3 genes play key roles in establishing all the main characteristics of the leukemias, while MEIS1 functions only to accelerate the onset of the leukemic transformation. Contrasting the reported functional similarities between PREP1 and MEIS1, such as PBX nuclear retention, we also show that PREP1 overexpression is incapable of accelerating the HOXA9-induced AML, suggesting that MEIS1 function in transformation must entail more than PBX nuclear localization. Collectively, these data demonstrate that MEIS1 is a common leukemic collaborator with two structurally and functionally divergent HOX genes and that, in this collaboration, the HOX gene defines the identity of the leukemia.
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Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
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Cited by
Germline Mutations in HOXB13 and Prostate-Cancer Risk
Ewing, C. M., Ray, A. M., Lange, E. M., Zuhlke, K. A., Robbins, C. M., Tembe, W. D., Wiley, K. E., Isaacs, S. D., Johng, D., Wang, Y., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110000 · Cited by 658
Hox genes in hematopoiesis and leukemogenesis
Argiropoulos, B., & Humphries, R. K. (2007) · Oncogene · doi:10.1038/sj.onc.1210760 · Cited by 492
Priam, P., Krasteva, V., Rousseau, P., D'Angelo, G., Gaboury, L., Sauvageau, G., & Lessard, J. A. (2017) · Nature Genetics · doi:10.1038/ng.3812 · Cited by 79
Metadata
- Authors
- Thorsteinsdottir, U., Kroon, E., Jerome, L., Blasi, F., & Sauvageau, G.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2001-01-01
- Volume
- 21
- Issue
- 1
- Pages
- 224-234
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2145307719
- Cited by
- 284
- References
- 37
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Thorsteinsdottir, U., Kroon, E., Jerome, L., Blasi, F., & Sauvageau, G. (2001). Defining Roles for HOX and MEIS1 Genes in Induction of Acute Myeloid Leukemia. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.21.1.224-234.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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