The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cell Type-Specific Phosphorylation and Proteolysis of a Transcriptional Regulator Controls the G1-to-S Transition in a Bacterial Cell Cycle
Open accessAbstract
The global transcriptional regulator CtrA controls multiple events in the Caulobacter cell cycle, including the initiation of DNA replication, DNA methylation, cell division, and flagellar biogenesis. CtrA is a member of the response regulator family of two component signal transduction systems and is activated by phosphorylation. We report here that this phosphorylation signal enters the cell cycle at mid S phase. In addition, CtrA function is modulated by temporally and spatially controlled proteolysis. When an active CtrA protein is present at the wrong time in the cell cycle, owing to expression of a mutant CtrA derivative that is active in the absence of phosphorylation and is not turned over during the cell cycle, the G1-to-S transition is blocked and the cell cycle aborts. Thus, both phosphorylation and proteolysis are critical determinants of bacterial cell cycle control in a manner that is analogous to the control of the eukaryotic cell cycle.
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Cites
How Proteolysis Drives the Cell Cycle
King, R. W., Deshaies, R. J., Peters, J.-M., & Kirschner, M. W. (1996) · Science · doi:10.1126/science.274.5293.1652 · Cited by 1,273
Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA
Keiler, K. C., Waller, P. R. H., & Sauer, R. T. (1996) · Science · doi:10.1126/science.271.5251.990 · Cited by 1,125
Cited by
Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis
Flynn, J. M., Levchenko, I., Seidel, M., Wickner, S. H., Sauer, R. T., & Baker, T. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191375298 · Cited by 334
Role of the GGDEF regulator PleD in polar development of Caulobacter crescentus
Aldridge, P., Paul, R., Goymer, P., Rainey, P., & Jenal, U. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03401.x · Cited by 272
Metadata
- Authors
- Domian, I. J., Quon, K. C., & Shapiro, L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 90
- Issue
- 3
- Pages
- 415-424
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1985253447
- Cited by
- 390
- References
- 2
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Cell Type-Specific Phosphorylation and Proteolysis of a Transcriptional Regulator Controls the G1-to-S Transition in a Bacterial Cell Cycle. https://app.cochat.ai/papers/10.1016/s0092-8674(00)80502-4
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- Domian, I. J., Quon, K. C., & Shapiro, L. (1997). Cell Type-Specific Phosphorylation and Proteolysis of a Transcriptional Regulator Controls the G1-to-S Transition in a Bacterial Cell Cycle. Cell. https://doi.org/10.1016/s0092-8674(00)80502-4
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