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Cited by 651

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TRAP Is Necessary for Gliding Motility and Infectivity of Plasmodium Sporozoites

Open access
Sultan, Ali A, Thathy, Vandana, Frevert, Ute, Robson, Kathryn J.H, Crisanti, Andrea, Nussenzweig, Victor, Nussenzweig, Ruth S, Ménard, Robert·1997·Cell

Abstract

Many protozoans of the phylum Apicomplexa are invasive parasites that exhibit a substrate-dependent gliding motility. Plasmodium (malaria) sporozoites, the stage of the parasite that invades the salivary glands of the mosquito vector and the liver of the vertebrate host, express a surface protein called thrombospondin-related anonymous protein (TRAP) that has homologs in other Apicomplexa. By gene targeting in a rodent Plasmodium, we demonstrate that TRAP is critical for sporozoite infection of the mosquito salivary glands and the rat liver, and is essential for sporozoite gliding motility in vitro. This suggests that in Plasmodium sporozoites, and likely in other Apicomplexa, gliding locomotion and cell invasion have a common molecular basis.

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Metadata

Authors
Sultan, A. A., Thathy, V., Frevert, U., Robson, K. J. H., Crisanti, A., Nussenzweig, V., Nussenzweig, R. S., & Ménard, R.
Venue
Cell
Publisher
Elsevier BV
Published
1997-08
Volume
90
Issue
3
Pages
511-522
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2015186773
Cited by
651
References
1
FWCI
33.36
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: TRAP Is Necessary for Gliding Motility and Infectivity of Plasmodium Sporozoites. https://app.cochat.ai/papers/10.1016/s0092-8674(00)80511-5
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Sultan, A. A., Thathy, V., Frevert, U., Robson, K. J. H., Crisanti, A., Nussenzweig, V., Nussenzweig, R. S., & Ménard, R. (1997). TRAP Is Necessary for Gliding Motility and Infectivity of Plasmodium Sporozoites. Cell. https://doi.org/10.1016/s0092-8674(00)80511-5

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