Sprouty, an Intracellular Inhibitor of Ras Signaling

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A new member of the frizzled family from Drosophila functions as a Wingless receptor

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Reiterative Use of the EGF Receptor Triggers Differentiation of All Cell Types in the Drosophila Eye

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Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

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Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling

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Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in Drosophila

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MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor

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A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules ofDrosophila

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Fasciclin 2, theDrosophilaorthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling

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The Sprouty‐related protein, Spred‐1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin‐1

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Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos

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Protein-tyrosine Phosphatase-1B (PTP1B) Mediates the Anti-migratory Actions of Sprouty

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Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

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FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos

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Overexpression Screen in Drosophila Identifies Neuronal Roles of GSK-3β/shaggyas a Regulator of AP-1-Dependent Developmental Plasticity

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Feedback control of the EGFR signaling gradient: superposition of domain-splitting events inDrosophilaoogenesis

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Hippo Reprograms the Transcriptional Response to Ras Signaling

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FGF Signalling in Vertebrate Development

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Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups

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Negative regulation of receptor tyrosine kinases by ubiquitination: Key roles of the Cbl family of E3 ubiquitin ligases

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Evolution and development of the mammalian dentition: Insights from the marsupial Monodelphis domestica

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Unraveling the Molecular Mechanisms That Lead to Supernumerary Teeth in Mice and Men: Current Concepts and Novel Approaches

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Sprouty Proteins Are Negative Regulators of Interferon (IFN) Signaling and IFN-inducible Biological Responses

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Small Wing PLCγ Is Required for ER Retention of Cleaved Spitz during Eye Development in Drosophila

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Intersection of Signal Transduction Pathways and Development

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Phosphorylation of Carboxyl-terminal Tyrosines Modulates the Specificity of Sprouty-2 Inhibition of Different Signaling Pathways

Rubin, C., Zwang, Y., Vaisman, N., Ron, D., & Yarden, Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m408308200 · Cited by 41

Regulation and function of FGF8 in patterning of midbrain and anterior hindbrain

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Suppression of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis

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Echinoid is essential for regulation of Egfr signaling and R8 formation during Drosophila eye development

Spencer, S. A., & Cagan, R. L. (2003) · Development · doi:10.1242/dev.00605 · Cited by 40

Conditional expression of Spry1 in neural crest causes craniofacial and cardiac defects

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Tesk1 Interacts with Spry2 to Abrogate Its Inhibition of ERK Phosphorylation Downstream of Receptor Tyrosine Kinase Signaling

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Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase

Tsumura, Y., Toshima, J., Leeksma, O., Ohashi, K., & Mizuno, K. (2005) · Biochemical Journal · doi:10.1042/bj20041181 · Cited by 39

Negative regulation of receptor tyrosine kinase signals

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Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer

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Sprouty2 enhances the tumorigenic potential of glioblastoma cells

Park, J., Wollmann, G., Urbiola, C., Fogli, B., Florio, T., Geley, S., & Klimaschewski, L. P. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy028 · Cited by 38

Molecular characterization of Patched‐associated rhabdomyosarcoma

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Prognostic and therapeutic impact of the KRAS G12C mutation in colorectal cancer

Qunaj, L., May, M. S., Neugut, A. I., & Herzberg, B. O. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1252516 · Cited by 42

Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway

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Graded Egfr activity patterns theDrosophilaeggshell independently of autocrine feedback

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Sprouty regulates cell migration by inhibiting the activation of Rac1 GTPase

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microRNA 21‐mediated suppression of sprouty1 by Pokemon affects liver cancer cell growth and proliferation

Jin, X., Sun, Q., Liu, F., Yang, H., Liu, M., Liu, H., Xu, W., & Jiang, Y. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24504 · Cited by 35

Sprouty genes regulate proliferation and survival of human embryonic stem cells

Felfly, H., & Klein, O. D. (2013) · Scientific Reports · doi:10.1038/srep02277 · Cited by 35

Evidence That Sprouty 2 Is Necessary for Sarcoma Formation by H-Ras Oncogene-transformed Human Fibroblasts

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Regulation of isthmic Fgf8 signal bysprouty2

Suzuki‐Hirano, A., Sato, T., & Nakamura, H. (2004) · Development · doi:10.1242/dev.01581 · Cited by 35

Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing

Terriente-Félix, A., & de Celis, J. F. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.03.010 · Cited by 34

Dual Effects of Sprouty1 on TCR Signaling Depending on the Differentiation State of the T Cell

Choi, H., Cho, S., Schwartz, R. H., & Choi, K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.10.6034 · Cited by 34

Functional analysis of the human Sprouty2 gene promoter

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Negative regulation of TGFβ-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists

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Modulation of Fgf8 activity during vertebrate brain development

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MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN

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Deregulation of the Egfr/Ras Signaling Pathway Induces Age-related Brain Degeneration in theDrosophilaMutantvap

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Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF‐β1 signaling and EGF as well as FGF receptor tyrosine kinase‐ERK pathways in mesenchymal cells

Ding, W., Shi, W., Bellusci, S., Groffen, J., Heisterkamp, N., Minoo, P., & Warburton, D. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21078 · Cited by 33

A Screen for Genes That Influence Fibroblast Growth Factor Signal Transduction in Drosophila

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MicroRNA-21 Mediates a Positive Feedback on Angiotensin II-Induced Myofibroblast Transformation

Li, D., Mao, C., Zhou, E., You, J., Gao, E., Han, Z., Fan, Y., He, Q. W., & Wang, C. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s285714 · Cited by 32

Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4,5-biphosphate hydrolysis

Ayada, T., Taniguchi, K., Okamoto, F., Kato, R., Komune, S., Takaesu, G., & Yoshimura, A. (2009) · Oncogene · doi:10.1038/onc.2008.464 · Cited by 32

The Ca2+-Calmodulin-Activated Protein Phosphatase Calcineurin Negatively Regulates Egf Receptor Signaling in Drosophila Development

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EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed

Yamada, T., Okabe, M., & Hiromi, Y. (2003) · Development · doi:10.1242/dev.00624 · Cited by 32

Low-Molecular-Weight Protein Tyrosine Phosphatase Is a Positive Component of the Fibroblast Growth Factor Receptor Signaling Pathway

Park, E. K., Warner, N. E., Mood, K., Pawson, T. J., & Daar, I. O. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3404-3414.2002 · Cited by 32

Taurine-Responsive Genes Related to Signal Transduction as Identified by cDNA Microarray Analyses of HepG2 Cells

Park, S.-H., Lee, H., Park, K. K., Kim, H. W., & Park, T. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.33 · Cited by 31

Sequential activation of ETS proteins provides a sustained transcriptional response to EGFR signaling

Shwartz, A., Yogev, S., Schejter, E. D., & Shilo, B. (2013) · Development · doi:10.1242/dev.093138 · Cited by 31

Regulatory mechanisms of EGFR signalling during Drosophila eye development

Malartre, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2153-x · Cited by 30

SPRY4 regulates trophoblast proliferation and apoptosis via regulating IFN‐γ‐induced STAT1 expression and activation in recurrent miscarriage

Qin, S., Zhang, Y., Zhang, J., Tian, F., Sun, L., He, X., Ma, X., Zhang, J., Liu, X., Zeng, W., et al. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13234 · Cited by 30

Direct Association of Sprouty-related Protein with an EVH1 Domain (SPRED) 1 or SPRED2 with DYRK1A Modifies Substrate/Kinase Interactions

Li, D., Jackson, R. A., Yusoff, P., & Guy, G. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.148445 · Cited by 32

Casein kinase 1 regulates Sprouty2 in FGF–ERK signaling

Yim, D., Ghosh, S., Guy, G. R., & Virshup, D. M. (2014) · Oncogene · doi:10.1038/onc.2013.564 · Cited by 30

Correlation of Sprouty1 and Jagged1 With Aggressive Prostate Cancer Cells With Different Sensitivities to Androgen Deprivation

Terada, N., Shiraishi, T., Zeng, Y., Yong, K. M. A., Mooney, S. M., Liu, Z., Takahashi, S., Luo, J., Lupold, S. E., Kulkarni, P., et al. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24805 · Cited by 29

Sprouty4 interferes with cell proliferation and migration of breast cancer-derived cell lines

Vanas, V., Mühlbacher, E., Kral, R. M., & Sutterlüty, H. (2014) · Tumor Biology · doi:10.1007/s13277-013-1587-0 · Cited by 29

Receptor Tyrosine Kinase Signaling

Fantauzzo, K. A., & Soriano, P. M. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2014.11.005 · Cited by 30

SOCS3 is required to temporally fine-tune photoreceptor cell differentiation

Ozawa, Y., Nakao, K., Shimazaki, T., Shimmura, S., Kurihara, T., Ishida, S., Yoshimura, A., Tsubota, K., & Okano, H. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.11.032 · Cited by 27

Altered regulation of the Spry2/Dyrk1A/PP2A triad by homocysteine impairs neural progenitor cell proliferation

Rabaneda, L. G., Geribaldi‐Doldán, N., Murillo‐Carretero, M., Carrasco, M., Martínez-Salas, J. M., Verástegui, C., & Castro, C. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.09.018 · Cited by 28

A bipolar role of the transcription factor ERG for cnidarian germ layer formation and apical domain patterning

Amiel, A., Johnston, H., Chock, T., Dahlin, P., Iglesias, M., Layden, M. J., Röttinger, É., & Martindale, M. Q. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.08.015 · Cited by 27

Sprouty2 but not Sprouty4 is a potent inhibitor of cell proliferation and migration of osteosarcoma cells

Rathmanner, N., Haigl, B., Vanas, V., Doriguzzi, A., Gsur, A., & Sutterlüty, H. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.06.040 · Cited by 27

Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia

Ching, S. T., Cunha, G. R., Baskin, L. S., Basson, M. A., & Klein, O. D. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.12.014 · Cited by 26

Time-resolved mapping of genetic interactions to model rewiring of signaling pathways

Heigwer, F., Scheeder, C., Miersch, T., Schmitt, B. A., Blass, C., Pour-Jamnani, M. V., & Boutros, M. (2018) · eLife · doi:10.7554/elife.40174 · Cited by 25

Inhibition of Angiogenesis by a Tenascin-C Peptide which Is Capable of Activating Beta1-Integrins

Saito, Y., Shiota, Y., Nishisaka, M., Owaki, T., Shimamura, M., & Fukai, F. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1003 · Cited by 26

A mRNA Landscape of Bovine Embryos after Standard and MAPK-Inhibited Culture Conditions: a Comparative Analysis

Brinkhof, B., van Tol, H. T., Groot Koerkamp, M. J., Riemers, F. M., IJzer, S. G., Mashayekhi, K., Haagsman, H. P., & Roelen, B. A. (2015) · BMC Genomics · doi:10.1186/s12864-015-1448-x · Cited by 26

Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity

Suzuki‐Hirano, A., Harada, H., Sato, T., & Nakamura, H. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.044 · Cited by 26

Doxycycline attenuates chronic intermittent hypoxia‐induced atrial fibrosis in rats

Wang, W., Zhang, K., Li, X., Ma, Z., Zhang, Y., Yuan, M., Suo, Y., Liang, X., Tse, G., Goudis, C. A., et al. (2018) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12321 · Cited by 26

A Functional Interaction between Sprouty Proteins and Caveolin-1

Cabrita, M. A., Jäggi, F., Widjaja, S. P., & Christofori, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603921200 · Cited by 26

New Negative Feedback Regulators of Egfr Signaling in Drosophila

Butchar, J. P., Cain, D. M., Manivannan, S., McCue, A. D., Bonanno, L. N., Halula, S. E., Truesdell, S. L., Austin, C. L., Jacobsen, T. L., & Simcox, A. A. (2012) · Genetics · doi:10.1534/genetics.112.141093 · Cited by 26

Bipartite Inhibition of Drosophila Epidermal Growth Factor Receptor by the Extracellular and Transmembrane Domains of Kekkon1

Alvarado, D., Rice, A. H., & Duffy, J. B. (2004) · Genetics · doi:10.1534/genetics.167.1.187 · Cited by 26

Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors

Ji, T., Zhang, L., Deng, M., Huang, S., Wang, Y., Pham, T. T., Smith, A. A., Sridhar, V., Cabernard, C., Wang, J., et al. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.040147 · Cited by 25

Extending the family table: Insights from beyond vertebrates into the regulation of embryonic development by FGFs

Tulin, S., & Stathopoulos, A. (2010) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20182 · Cited by 25

Transcriptional and post-transcriptional regulation of Sprouty1, a receptor tyrosine kinase inhibitor in prostate cancer

Darimipourain, M., Wang, S., Ittmann, M., & Kwabi‐Addo, B. (2011) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2011.33 · Cited by 25

Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction

Martinez, N. J., García-Domínguez, C. A., Domingo, B., Oliva, J. L., Zarich, N., Sánchez, A., Gutiérrez-Eisman, S., Llopis, J. L., & Rojas, J. M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.07.008 · Cited by 25

Activation of the EGFR/MAPK pathway drives transdifferentiation of quiescent niche cells to stem cells in the Drosophila testis niche

Greenspan, L. J., de Cuevas, M., Le, K. H., Viveiros, J. M., & Matunis, E. L. (2022) · eLife · doi:10.7554/elife.70810 · Cited by 25

Regulation of sprouty expression by PLCγ and calcium-dependent signals

Abe, M., & Naski, M. C. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.198 · Cited by 24

Sprouty2—a Novel Therapeutic Target in the Nervous System?

Hausott, B., & Klimaschewski, L. P. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1338-8 · Cited by 24

Selective Killing of RAS-Malignant Tissues by Exploiting Oncogene-Induced DNA Damage

Murcia, L., Clemente‐Ruiz, M., Pierre-Elies, P., Royou, A., & Milán, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.004 · Cited by 24

Modulation of Endocrine Pancreas Development but not β-Cell Carcinogenesis by Sprouty4

Jäggi, F., Cabrita, M. A., Perl, A. T., & Christofori, G. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0255 · Cited by 23

Establishment of Extracellular Signal-Regulated Kinase 1/2 Bistability and Sustained Activation through Sprouty 2 and Its Relevance for Epithelial Function

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