Sprouty, an Intracellular Inhibitor of Ras Signaling

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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A new member of the frizzled family from Drosophila functions as a Wingless receptor

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Reiterative Use of the EGF Receptor Triggers Differentiation of All Cell Types in the Drosophila Eye

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Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

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A Functional Domain of Dof That Is Required for Fibroblast Growth Factor Signaling

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Drosophila cbl Is Essential for Control of Cell Death and Cell Differentiation during Eye Development

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Sprouty gain of function disrupts lens cellular processes and growth by restricting RTK signaling

Shin, E. H. H., Zhao, G., Wang, Q., & Lovicu, F. J. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.09.005 · Cited by 19

Regulation of EGFR and Notch signaling by distinct isoforms of D-cbl during Drosophila development

Wang, Y., Chen, Z., & Bergmann, A. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.03.005 · Cited by 19

Correction: Spry1 Is Expressed in Hemangioblasts and Negatively Regulates Primitive Hematopoiesis and Endothelial Cell Function

Yang, X., Gong, Y., & Friesel, R. E. (2012) · PLoS ONE · doi:10.1371/annotation/eb3485a7-612b-4244-8d2a-43a80cdd15eb · Cited by 19

Activation of Unfolded Protein Response in Transgenic Mouse Lenses

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Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells

Arafeh, R., Flores, K., Keren‐Paz, A., Maik-Rachline, G., Gutkind, N. E., Rosenberg, S. A., Seger, R., & Samuels, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-16558-0 · Cited by 18

Recruitment of Sprouty1 to Immune Synapse Regulates T Cell Receptor Signaling

Lee, J. S., Lee, J., Oh, Y. M., Park, J. B., Choi, H., Choi, C. Y., Kim, I.-H., Lee, S. H., & Choi, K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803799 · Cited by 18

Incidence of P53 and K‐ras alterations in ovarian mucinous and serous tumors

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A fly's eye view of EGF receptor signalling

Freeman, M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf679 · Cited by 18

Cell migration in Drosophila

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Role of SPRY4 in health and disease

Pan, H., Xu, R., & Zhang, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1376873 · Cited by 17

Astroglial transcriptome dysregulation in early disease of an ALS mutant SOD1 mouse model

Miller, S., Zhang, P.-W., Glatzer, J. C., & Rothstein, J. D. (2016) · Journal of Neurogenetics · doi:10.1080/01677063.2016.1260128 · Cited by 18

Eve-3: A liver enriched suppressor of Ras/MAPK signaling

King, J. A. J., Corcoran, N. M., D’Abaco, G. M., Straffon, A. F. L., Smith, C. T., Poon, C. L. C., Büchert, M., Stacey, I., Hall, N. E., Lock, P., et al. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.10.031 · Cited by 17

Identification of Genomic Regions That Interact With a Viable Allele of the Drosophila Protein Tyrosine Phosphatase Corkscrew

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Airway patterning: A paradigm for restricted signalling

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Genetic analysis of vein function in the Drosophila embryonic nervous system

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FGF signaling acts on different levels of mesoderm development within Spiralia

Andrikou, C., & Hejnol, A. (2021) · Development · doi:10.1242/dev.196089 · Cited by 15

SNT1/FRS2 Mediates Germinal Vesicle Breakdown Induced by an Activated FGF Receptor1 in Xenopus Oocytes

Mood, K., Friesel, R. E., & Daar, I. O. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203894200 · Cited by 16

A modifier screen of ectopic Krüppel activity identifies autosomal Drosophila chromosomal sites and genes required for normal eye development

Abrell, S., Carrera, P., & Jäckle, H. (2000) · Chromosoma · doi:10.1007/s004120000092 · Cited by 16

Signaling by the Drosophila epidermal growth factor receptor pathway during development

Shilo, B. (2003) · Elsevier eBooks · doi:10.1016/b978-012160281-9/50013-x · Cited by 16

Functional and Comparative Genomic Analysis of the Piebald Deletion Region of Mouse Chromosome 14

Peterson, K. A., King, B. L., Hagge-Greenberg, A., Roix, J. J., Bult, C. J., & O’Brien, T. P. (2002) · Genomics · doi:10.1006/geno.2002.6818 · Cited by 16

Human Sprouty1 suppresses growth, migration, and invasion in human breast cancer cells

Mekkawy, A. H., Pourgholami, M. H., & Morris, D. L. (2014) · Tumor Biology · doi:10.1007/s13277-014-1665-y · Cited by 15

Sprouty2 regulates positioning of retinal progenitors through suppressing the Ras/Raf/MAPK pathway

Sun, J., Yoon, J., Lee, M., Hwang, Y., & Daar, I. O. (2020) · Scientific Reports · doi:10.1038/s41598-020-70670-2 · Cited by 15

Spred negatively regulates lens growth by modulating epithelial cell proliferation and fiber differentiation

Susanto, A., Zhao, G., Wazin, F., Feng, Y., Rasko, J. E. J., Bailey, C. G., & Lovicu, F. J. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.09.019 · Cited by 15

Sprouty2 Interacts with Protein Kinase Cδ and Disrupts Phosphorylation of Protein Kinase D1

Chow, S. Y., Yu, C. Y., & Guy, G. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021600 · Cited by 15

Generation of distinct signaling modes via diversification of the Egfr ligand-processing cassette

Rousso, T., Lynch, J., Yogev, S., Roth, S., Schejter, E. D., & Shilo, B. (2010) · Development · doi:10.1242/dev.049858 · Cited by 15

Exogenous FGF-4 Can Suppress Anterior Development in the Mouse Embryo during Neurulation and Early Organogenesis

Davidson, B. P., Cheng, L. Y., Kinder, S. J., & Tam, P. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9663 · Cited by 15

SPRED proteins provide a NF-ty link to Ras suppressionPreprint

McClatchey, A. I., & Cichowski, K. M. (2012) · Genes & Development · doi:10.1101/gad.197434.112 · Cited by 15

Tumor-specifically hypoxia-induced therapy of SPRY1/2 displayed differential therapeutic efficacy for melanoma.

Liu, Z., Liu, X., Cao, W., & Hua, Z. (2015) · Europe PMC (PubMed Central) · Cited by 14

How Genetics Has Helped Piece Together the MAPK Signaling Pathway

Ashton‐Beaucage, D., & Therrien, M. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6424-6_1 · Cited by 15

The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during Drosophila eye development

Martin-Bermudo, M. D., Bardet, P., Bellaı̈che, Y., & Malartre, M. (2015) · Development · doi:10.1242/dev.110585 · Cited by 14

Targeted gain-of-function screening inDrosophilausingGAL4-UASand random transposon insertions

Zhong, J., & Yedvobnick, B. (2009) · Genetics Research · doi:10.1017/s0016672309990152 · Cited by 14

Cell‐type specific utilization of multiple negative feedback loops generates developmental constancy

Iwanami, M., Hiromi, Y., & Okabe, M. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00871.x · Cited by 14

Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty

Frey, M. R., Carraro, G., Batra, R. K., Polk, D. B., & Warburton, D. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.1.14176 · Cited by 13

In non‐small cell lung cancer mitogenic signaling leaves Sprouty1 protein levels unaffected

Kral, R. M., Mayer, C., Vanas, V., Gsur, A., & Sutterlüty, H. (2013) · Cell Biochemistry and Function · doi:10.1002/cbf.2976 · Cited by 13

Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways

Taketomi, T., Onimura, T., Yoshiga, D., Muratsu, D., Sanui, T., Fukuda, T., Kusukawa, J., & Nakamura, S. (2017) · Cell Biology International · doi:10.1002/cbin.10876 · Cited by 13

Enhancer detection and developmental expression of zebrafish sprouty1, a member of the fgf8 synexpression group

Komisarczuk, A. Z., Topp, S., Stigloher, C., Kapsimali, M., Bally‐Cuif, L., & Becker, T. S. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21689 · Cited by 13

Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2

Sathyanarayana, P., Dev, A., Pradeep, A., Ufkin, M. L., Licht, J. D., & Wojchowski, D. M. (2012) · Blood · doi:10.1182/blood-2011-11-392571 · Cited by 13

Xenopus marginal coil (Xmc), a novel FGF inducible cytosolic coiled-coil protein regulating gastrulation movements

Frazzetto, G., Klingbeil, P., & Bouwmeester, T. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00664-5 · Cited by 13

Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula

Cooper, E. J., & Scholpp, S. (2023) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2023.12.003 · Cited by 12

Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred

Zhao, G., Bailey, C. G., Feng, Y., Rasko, J. E. J., & Lovicu, F. J. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.02.025 · Cited by 12

Developmental roles of Rhomboid proteases

Shilo, B. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.07.014 · Cited by 12

FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac

Li-Villarreal, N., Wong, R. L. Y., Garcia, M. D., Udan, R. S., Poché, R. A., Rasmussen, T. L., Rhyner, A. M., Wythe, J. D., & Dickinson, M. E. (2022) · Development · doi:10.1242/dev.200131 · Cited by 11

Sprouty2 Regulates PI(4,5)P2/Ca2+ Signaling and HIV-1 Gag Release

Ehrlich, L. S., Medina, G. N., & Carter, C. A. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.04.069 · Cited by 11

Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion

So, W., Cheng, J., Fan, Q., Wong, A. S. T., Huntsman, D. D., Gilks, C. B., & Leung, P. C. K. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.12.012 · Cited by 11

siRNA mediated down-regulation of Sprouty2/4 diminishes ischemic brain injury

Klimaschewski, L. P., Sueiro, B. P., & Millán, L. M. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.11.050 · Cited by 11

Sprouty2 expression controls endothelial monolayer integrity and quiescence

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Hypoxia inducible factors regulate the transcription of the sprouty2 gene and expression of the sprouty2 protein

Gao, X., Hicks, K. C., Neumann, P. H., & Patel, T. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171616 · Cited by 11

What goes up must come down

Leevers, S. J. (1999) · Nature Cell Biology · doi:10.1038/8960 · Cited by 11

Exogenous Fibroblast Growth Factor-10 Induces Cystic Lung Development with Altered Target Gene Expression in the Presence of Heparin in Cultures of Embryonic Rat Lung

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Molecular mechanisms underlying cellular effects of human MEK1 mutations

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Sprouty4 negatively regulates ERK/MAPK signaling and the transition from in situ to invasive breast ductal carcinoma

Brock, E. J., Jackson, R. M., Boerner, J. L., Li, Q., Tennis, M. A., Sloane, B. F., & Mattingly, R. R. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252314 · Cited by 10

Spry1 Is Expressed in Hemangioblasts and Negatively Regulates Primitive Hematopoiesis and Endothelial Cell Function

Yang, X., Gong, Y. Q., & Friesel, R. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018374 · Cited by 10

Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-α

Ding, W., & Warburton, D. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.037 · Cited by 10

Overexpression of Cancer Upregulated Gene 2 (CUG2) Decreases Spry2 Through c-Cbl, Leading to Activation of EGFR and β-Catenin Signaling

Yawut, N., Kaewpiboon, C., Budluang, P., Cho, I.-R., Kaowinn, S., Koh, S. S., & Chung, Y.-H. (2020) · Cancer Management and Research · doi:10.2147/cmar.s271109 · Cited by 9

Functional interaction between Envoncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2

Chitra, E., Lin, Y., Davamani, F. A., Hsiao, K.-N., Sia, C., Hsieh, S.-Y., Wei, O. L., Chen, J., & Chow, Y. (2010) · Retrovirology · doi:10.1186/1742-4690-7-62 · Cited by 9

The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in theDrosophilaeye

Sesé, M., Corominas, M., Stocker, H., Heino, T. I., Hafen, E., & Serras, F. (2006) · Journal of Cell Science · doi:10.1242/jcs.03294 · Cited by 9

NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways

Sheng, Z., & Du, W. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008863 · Cited by 8

SPRY4 inhibits and sensitizes the primary KIT mutants in gastrointestinal stromal tumors (GISTs) to imatinib

Li, S., Zhao, S., Liang, N., Zhang, S., Zhang, L., Zhou, L., Liu, A., Cao, X., Tian, J., Yu, Y., et al. (2023) · Gastric Cancer · doi:10.1007/s10120-023-01402-4 · Cited by 8

Sex specific gene expression is present prior to metamorphosis in the sea urchin

Pieplow, C. A., Furze, A. R., Gregory, P., Oulhen, N., & Wessel, G. M. (2024) · Developmental Biology · doi:10.1016/j.ydbio.2024.10.003 · Cited by 8

Ras-Gefs and Ras Gaps

Rojas, J. M., & Santos, E. (2006) · Springer eBooks · doi:10.1007/1-4020-4708-8_2 · Cited by 8

RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye

SUKHANOVA, M. J., Steele, L. J., Zhang, T., Gordon, G. M., & Du, W. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.08.018 · Cited by 8

Future Aspects of Tumor Suppressor Gene

Cheng, Y. (2013) · InTech eBooks · doi:10.5772/56471 · Cited by 8

Morphogenetic and Histogenetic Roles of the Temporal-Spatial Organization of Cell Proliferation in the Vertebrate Corticogenesis as Revealed by Inter-specific Analyses of the Optic Tectum Cortex Development

Rapacioli, M., Palma, V., & Flores, V. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00067 · Cited by 8

Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development

Selland, L. G., Koch, S., Laraque, M., & Waskiewicz, A. J. (2018) · Mechanisms of Development · doi:10.1016/j.mod.2018.02.005 · Cited by 8

Modulation of Mosquito Immune Defenses as a Control Strategy

Rhodes, V. L. M., & Michel, K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805350-8.00004-0 · Cited by 8

Argos Mutants Define an Affinity Threshold for Spitz Inhibition in Vivo

Alvarado, D., Evans, T. A., Sharma, R., Lemmon, M. A., & Duffy, J. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603782200 · Cited by 8

Personalized approaches to lung cancer treatment: A review of targeted therapies, pharmacogenomics, and combination strategies

Namini, M. T., Bhagya, G., & Sharma, M. (2025) · Aspects of Molecular Medicine · doi:10.1016/j.amolm.2025.100073 · Cited by 7

Cosuppression of Sprouty and Sprouty-Related Negative Regulators of FGF Signalling in Prostate Cancer: A Working Hypothesis

Assinder, S. J., Beniamen, D., & Lovicu, F. J. (2015) · BioMed Research International · doi:10.1155/2015/827462 · Cited by 7

The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis

Wazin, F., & Lovicu, F. J. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.107917 · Cited by 7

Current challenges to underpinning the genetic basis for cholangiocarcinoma

Cigliano, A., Chen, X., & Calvisi, D. F. (2021) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1915128 · Cited by 9

Regulator of Epidermal Growth Factor Signaling: Sprouty

Wong, E. S. M., & Guy, G. R. (2006) · Humana Press eBooks · doi:10.1385/1-59745-012-x:61 · Cited by 7

Mutations Modulating the Argos-Regulated Signaling Pathway in Drosophila Eye Development

Taguchi, A., Sawamoto, K., & Okano, H. (2000) · Genetics · doi:10.1093/genetics/154.4.1639 · Cited by 7

MIG-6 and SPRY2 in the Regulation of Receptor Tyrosine Kinase Signaling: Balancing Act via Negative Feedback Loops

Zhang, Y., & Woude, G. F. V. (2013) · InTech eBooks · doi:10.5772/54393 · Cited by 8

Human Sprouty1 Suppresses Urokinase Receptor-Stimulated Cell Migration and Invasion

Mekkawy, A. H., & Morris, D. L. (2013) · ISRN Biochemistry · doi:10.1155/2013/598251 · Cited by 6

EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis

Beatty, J. S., Molnar, C., Luque, C. M., de Celis, J. F., & Martin-Bermudo, M. D. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009738 · Cited by 6

SPRY4 promotes adipogenic differentiation of human mesenchymal stem cells through the MEK–ERK1/2 signaling pathway

Li, N., Chen, Y., Wang, H., Li, J., & Zhao, R. C. (2022) · Adipocyte · doi:10.1080/21623945.2022.2123097 · Cited by 6

SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling

Cui, Y.-Z., Xu, F., Zhou, Y., Wang, Z., Yang, X.-Y., Fu, N.-C., Chen, X., Zheng, Y., Chen, X., Ye, L., et al. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.02.018 · Cited by 6

Sprouty2 and Spred1-2 Proteins Inhibit the Activation of the ERK Pathway Elicited by Cyclopentenone Prostanoids

García-Domínguez, C. A., Martinez, N. J., Gragera, T., Pérez-Rodríguez, A., Retana, D., León‐Espinosa, G., Sánchez, A., Oliva, J. L., Pérez‐Sala, D., & Rojas, J. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016787 · Cited by 6

Sprouty is a cytoplasmic target of adenoviral E1A oncoproteins to regulate the receptor tyrosine kinase signalling pathway

Zaremba, A., Schmuecker, U., & Esche, H. (2011) · Virology Journal · doi:10.1186/1743-422x-8-192 · Cited by 6

Spry2-mediated inhibition of the Ras/ERK pathway through interaction with Src kinase following cerebral ischemia

Wu, H., Wu, H., Li, H., Wu, H., Li, H., & Guo, J. (2008) · Brain Injury · doi:10.1080/02699050801911295 · Cited by 6

Conditional Ablation of Spred1 and Spred2 in the Eye Lens Negatively Impacts Its Development and Growth

Wazin, F., & Lovicu, F. J. (2024) · Cells · doi:10.3390/cells13040290 · Cited by 5

Sprouty2 Regulates Endocytosis and Degradation of Fibroblast Growth Factor Receptor 1 in Glioblastoma Cells

Hausott, B., Pircher, L., Kind, M., Park, J., Claus, P., Obexer, P., & Klimaschewski, L. P. (2024) · Cells · doi:10.3390/cells13231967 · Cited by 5

Immunolocalization of Sprouty-1 and Sprouty-2 in Developing Rat Lung

Hashimoto, S., Nakano, H., Suguta, Y., Singh, G., & Katyal, S. L. (2012) · Pathobiology · doi:10.1159/000332215 · Cited by 5

Cell adaptation to activated FGFR3 includes Sprouty4 up regulation to inhibit the receptor‐mediated ERKs activation from the endoplasmic reticulum

Lievens, P., Zanolli, E., Garofalo, S., & Liboi, E. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.09.021 · Cited by 5

The MET Receptor Family

Gao, C., & Woude, G. F. V. (2015) · Springer eBooks · doi:10.1007/978-3-319-11888-8_8 · Cited by 5

Cardiovascular Genomics: A Current Overview of In Vivo and In Vitro Studies

Mariappan, D., Winkler, J., Hescheler, J., & Sachinidis, A. (2006) · Stem Cell Reviews and Reports · doi:10.1007/s12015-006-0010-2 · Cited by 5

Buffered EGFR signaling regulated by spitz-to-argos expression ratio is a critical factor for patterning the Drosophila eye

Pasnuri, N., Jaiswal, M., Ray, K., & Mazumder, A. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010622 · Cited by 3

Regulation of EGF Receptor Signaling in the Fruitfly D. melanogaster and the Nematode C. elegans

Lacenere, C. J., & Sternberg, P. W. (2000) · Breast Disease · doi:10.3233/bd-1999-11103 · Cited by 4

HelmsmanIs Expressed in Both Trachea and Photoreceptor Development: Partial Inactivation Alters Tracheal Morphology and Visually Guided Behavior

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Oogenesis

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