The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Phosphorylation of Histone H3 Is Required for Proper Chromosome Condensation and Segregation
Open accessAbstract
Phosphorylation of histone H3 at serine 10 occurs during mitosis in diverse eukaryotes and correlates closely with mitotic and meiotic chromosome condensation. To better understand the function of H3 phosphorylation in vivo, we created strains of Tetrahymena in which a mutant H3 gene (S10A) was the only gene encoding the major H3 protein. Although both micronuclei and macronuclei contain H3 in typical nucleosomal structures, defects in nuclear divisions were restricted to mitotically dividing micronuclei; macronuclei, which are amitotic, showed no defects. Strains lacking phosphorylated H3 showed abnormal chromosome segregation, resulting in extensive chromosome loss during mitosis. During meiosis, micronuclei underwent abnormal chromosome condensation and failed to faithfully transmit chromosomes. These results demonstrate that H3 serine 10 phosphorylation is causally linked to chromosome condensation and segregation in vivo and is required for proper chromosome dynamics.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Histone acetylation and transcriptional regulatory mechanisms
Struhl, K. (1998) · Genes & Development · doi:10.1101/gad.12.5.599 · Cited by 1,815
Signaling to Chromatin through Histone Modifications
Cheung, P., Allis, C. D., & Sassone-Corsi, P. (2000) · Cell · doi:10.1016/s0092-8674(00)00118-5 · Cited by 989
Self-citation
Cited by
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Self-citationThe language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679
Self-citationRegulation of chromatin structure by site-specific histone H3 methyltransferases
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845
Self-citationLoss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability
Peters, A. H. F. M., O'Carroll, D., Scherthan, H., Mechtler, K., Sauer, S., Schöfer, C., Weipoltshammer, K., Pagani, M., Lachner, M., Kohlmaier, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00542-6 · Cited by 1,766
Meiotic Chromosomes: Integrating Structure and Function
Zickler, D., & Kleckner, N. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.603 · Cited by 1,255
Metadata
- Authors
- Wei, Y., Yu, L., Bowen, J., Gorovsky, M. A., & Allis, C. D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 97
- Issue
- 1
- Pages
- 99-109
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2061805545
- Cited by
- 718
- References
- 3
- FWCI
- 17.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wei, Y., Yu, L., Bowen, J., Gorovsky, M. A., & Allis, C. D. (1999). Phosphorylation of Histone H3 Is Required for Proper Chromosome Condensation and Segregation. Cell. https://doi.org/10.1016/s0092-8674(00)80718-7
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