The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Model for Arrestin’s Regulation: The 2.8 Å Crystal Structure of Visual Arrestin
Open accessAbstract
G protein-coupled signaling is utilized by a wide variety of eukaryotes for communicating information from the extracellular environment. Signal termination is achieved by the action of the arrestins, which bind to activated, phosphorylated G protein-coupled receptors. We describe here crystallographic studies of visual arrestin in its basal conformation. The salient features of the structure are a bipartite molecule with an unusual polar core. This core is stabilized in part by an extended carboxy-terminal tail that locks the molecule into an inactive state. In addition, arrestin is found to be a dimer of two asymmetric molecules, suggesting an intrinsic conformational plasticity. In conjunction with biochemical and mutagenesis data, we propose a molecular mechanism by which arrestin is activated for receptor binding.
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[20] Processing of X-ray diffraction data collected in oscillation mode
Otwinowski, Z., & Minor, W. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76066-x · Cited by 33,475
PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
Kabsch, W., & Sander, C. (1983) · Biopolymers · doi:10.1002/bip.360221211 · Cited by 15,320
Cited by
Pan, L., Gurevich, E. V., & Gurevich, V. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209532200 · Cited by 1,759
Self-citationThe role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
Luttrell, L. M., & Lefkowitz, R. J. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.3.455 · Cited by 1,122
Structure and dynamics of GPCR signaling complexes
Hilger, D., Masureel, M., & Kobilka, B. K. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-017-0011-7 · Cited by 969
Kirchhausen, T. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.699 · Cited by 560
The Structural Era of Endocytosis
Marsh, M., & McMahon, H. T. (1999) · Science · doi:10.1126/science.285.5425.215 · Cited by 560
Metadata
- Authors
- Hirsch, J. A., Schubert, C., Gurevich, V. V., & Sigler, P. B.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 97
- Issue
- 2
- Pages
- 257-269
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1994539207
- Cited by
- 436
- References
- 3
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hirsch, J. A., Schubert, C., Gurevich, V. V., & Sigler, P. B. (1999). A Model for Arrestin’s Regulation: The 2.8 Å Crystal Structure of Visual Arrestin. Cell. https://doi.org/10.1016/s0092-8674(00)80735-7
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