Cited by 560Cellular transport and secretionReceptor Mechanisms and SignalingCaveolin-1 and cellular processes

Clathrin

Kirchhausen, Tomas·2000·Annual Review of Biochemistry

Abstract

▪ Abstract Clathrin was discovered nearly 25 years ago. Since then, a large number of other proteins that participate in the process by which clathrin-coated vesicles retrieve synaptic membranes or take up endocytic receptors have been identified. The functional relationships among these disparate components remain, in many cases, obscure. High-resolution structures of parts of clathrin, determined by X-ray crystallography, and lower-resolution images of assembled coats, determined by electron cryomicroscopy, now provide the information necessary to integrate various lines of evidence and to design experiments that test specific mechanistic notions. This review summarizes and illustrates the recent structural results and outlines what is known about coated-vesicle assembly in the context of this information.

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Crossref · 10.1146/annurev.biochem.69.1.699

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  • The AP1 complex functions in intracellular transport of cargo proteins between the trans-Golgi apparatus and endosomes by linking clathrin to cargo proteins during vesicle membrane formation, and is important for somatodendritic transport of proteins required for neuronal polarity.

    “The AP1 complex functions in the intracellular transport of cargo proteins between the trans-Golgi apparatus and endosomes by linking clathrin to the cargo proteins during vesicle membrane formation (Kirchhausen, 2000), and is important for the somatodendritic transport of proteins required for neuronal polarity (Farias et al., 2012).”

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Authors
Kirchhausen, T.
Affiliations
Harvard University (US)
Corresponding author
Kirchhausen, Tomas
Venue
Annual Review of Biochemistry
Published
2000-06
Volume
69
Issue
1
Pages
699-727
ISSN
  • 0066-4154 (ISSN-L)
  • 1545-4509
OpenAlex
W4251652273
Cited by
560
References
148
Citations by year
2026: 15 · 2025: 11 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 22 · 2020: 12 · 2019: 10 · 2018: 22 · 2017: 12 · 2016: 17 · 2015: 12 · 2014: 22 · 2013: 28 · 2012: 17
FWCI
2.68
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords
clathrin, clathrin-coated vesicles, endocytic receptor, X-ray crystallography, cryo-electron microscopy, endocytosis
MeSH terms
Amino Acid Sequence, Animals, Clathrin, Coated Pits, Cell-Membrane, Humans, Models, Molecular, Sequence Homology, Amino Acid, Protein Structure, Quaternary

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