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SUMO-1 Modification of Mdm2 Prevents Its Self-Ubiquitination and Increases Mdm2 Ability to Ubiquitinate p53
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Citations
Cites
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · cited 1×
“To this end, we compared the effects of the wt Mdm2 and the K1 mutant on p53 accumulation in a cotransfection assay (Haupt et al., 1997; Kubbutat et al., 1997). p53/Mdm2 double null cells (Jones et al., 1995) were used to exclude the influence of endogenous Mdm2.”
BackgroundDNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
Honda, R., Tanaka, H., & Yasuda, H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01480-4 · Cited by 1,951
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
Jones, S. N., Roe, A. E., Donehower, L. A., & Bradley, A. (1995) · Nature · doi:10.1038/378206a0 · Cited by 1,280
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
Kamijo, T., Weber, J. D., Zambetti, G., Zindy, F., Roussel, M. F., & Sherr, C. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8292 · Cited by 899
DNA damage induces phosphorylation of the amino terminus of p53
Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., & Kastan, M. B. (1997) · Genes & Development · doi:10.1101/gad.11.24.3471 · Cited by 818
Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
Honda, R., & Yasuda, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.22 · Cited by 724
Nedd8 Modification of Cul-1 Activates SCFβTrCP-Dependent Ubiquitination of IκBα
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Cited by
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607
Mechanisms Underlying Ubiquitination
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Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation
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Metadata
- Authors
- Buschmann, T., Fuchs, S. Y., Lee, C.-G., Pan, Z.-Q., & Ronai, Z.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 101
- Issue
- 7
- Pages
- 753-762
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2080485991
- Cited by
- 269
- References
- 9
- FWCI
- 12.17
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 4794 d)
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- The paper
- Buschmann, T., Fuchs, S. Y., Lee, C.-G., Pan, Z.-Q., & Ronai, Z. (2000). SUMO-1 Modification of Mdm2 Prevents Its Self-Ubiquitination and Increases Mdm2 Ability to Ubiquitinate p53. Cell. https://doi.org/10.1016/s0092-8674(00)80887-9
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