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2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region
Open accessAbstract
We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.
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PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
Kabsch, W., & Sander, C. (1983) · Biopolymers · doi:10.1002/bip.360221211 · Cited by 15,320
Cited by
Bioactive modification of poly (ethylene glycol) hydrogels for tissue engineering
Zhu, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.044 · Cited by 1,457
Garcı́a, A. J., Vega, M. D., & Boettiger, D. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.3.785 · Cited by 659
Halper, J., & Kjaer, M. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-94-007-7893-1_3 · Cited by 532
Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus
Koo, L. Y., Irvine, D. J., Mayes, A. M., Lauffenburger, D. A., & Griffith, L. G. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.7.1423 · Cited by 420
Melby, T. E., Ciampaglio, C. N., Briscoe, G., & Erickson, H. P. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.6.1595 · Cited by 384
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Metadata
- Authors
- Leahy, D. J., Aukhil, I., & Erickson, H. P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 84
- Issue
- 1
- Pages
- 155-164
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2147791888
- Cited by
- 640
- References
- 2
- FWCI
- 16.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: 2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81002-8
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- Leahy, D. J., Aukhil, I., & Erickson, H. P. (1996). 2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region. Cell. https://doi.org/10.1016/s0092-8674(00)81002-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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