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Cited by 1,457Hydrogels: synthesis, properties, applicationsTissue Engineering and Regenerative MedicineSilk-based biomaterials and applications

Bioactive modification of poly (ethylene glycol) hydrogels for tissue engineering

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Zhu, Junmin·2010·Biomaterials
DOI 10.1016/j.biomaterials.2010.02.044PMC PMC2907908
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Abstract

In this review, we explore different approaches for introducing bioactivity into poly(ethylene glycol) (PEG) hydrogels. Hydrogels are excellent scaffolding materials for repairing and regenerating a variety of tissues because they can provide a highly swollen three-dimensional (3D) environment similar to soft tissues. Synthetic hydrogels like PEG-based hydrogels have advantages over natural hydrogels, such as the ability for photopolymerization, adjustable mechanical properties, and easy control of scaffold architecture and chemical compositions. However, PEG hydrogels alone cannot provide an ideal environment to support cell adhesion and tissue formation due to their bio-inert nature. The natural extracellular matrix (ECM) has been an attractive model for the design and fabrication of bioactive scaffolds for tissue engineering. ECM-mimetic modification of PEG hydrogels has emerged as an important strategy to modulate specific cellular responses. To tether ECM-derived bioactive molecules (BMs) to PEG hydrogels, various strategies have been developed for the incorporation of key ECM biofunctions, such as specific cell adhesion, proteolytic degradation, and signal molecule-binding. A number of cell types have been immobilized on bioactive PEG hydrogels to provide fundamental knowledge of cell/scaffold interactions. This review addresses the recent progress in material designs and fabrication approaches leading to the development of bioactive hydrogels as tissue engineering scaffolds.

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  • PEG is a versatile and biocompatible synthetic biomaterial for postoperative anti-adhesion barrier films, primarily due to its hydrophilic nature, low protein adsorption, and tunable degradation.

    “Polyethylene glycol (PEG) has established itself as a versatile and biocompatible synthetic biomaterial in postoperative anti-adhesion barrier films, primarily due to its hydrophilic nature, low protein adsorption, and tunable degradation properties [207,208].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [208]

    The Introduction describes PEG as hydrophilic, biocompatible, resistant to protein adsorption, and versatile for biomedical uses. It also explains that PEG hydrogels can be modified to enhance degradation. The cited passages discuss tissue-engineering hydrogels, however, not postoperative anti-adhesion barrier films or why PEG is used in those films. (LLM, conf=0.88)

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Authors
Zhu, J.
Affiliations
Case Western Reserve University (US)
Corresponding author
Zhu, Junmin
ORCID
Zhu, Junmin
Venue
Biomaterials
Publisher
Elsevier BV
Published
2010-06
Volume
31
Issue
17
Pages
4639-4656
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/j.biomaterials.2010.02.044
PMC
PMC2907908
OpenAlex
W2042617428
Cited by
1,457
References
3
Citations by year
2026: 89 · 2025: 126 · 2024: 103 · 2023: 106 · 2022: 89 · 2021: 119 · 2020: 104 · 2019: 105 · 2018: 123 · 2017: 97 · 2016: 77 · 2015: 77 · 2014: 73 · 2013: 57 · 2012: 63
FWCI
2.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (1R01HL087843, 1RC1EB010795, 5R01EB002067)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Keywords
poly(ethylene glycol) hydrogels, bioactive hydrogels, tissue engineering scaffolds, extracellular matrix mimics, cell adhesion, proteolysis, cell-scaffold interaction, synthetic hydrogels
MeSH terms
Extracellular Matrix, Nitric Oxide, Polyethylene Glycols, Extracellular Matrix Proteins, Hydrogels, Tissue Engineering, Intercellular Signaling Peptides and Proteins, Tissue Scaffolds

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