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Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles
Open accessAbstract
S. cerevisiae inherits its vacuole by projecting vacuole-derived membrane vesicles and tubules into the bud, where they fuse to establish the daughter vacuole. This homotypic fusion event can be assayed in vitro. It requires Sec17p and Sec18p, the homologs of the mammalian alpha-SNAP and NSF, which cooperate in multiple steps of membrane trafficking. We now report that Sec17p, Sec18p, and ATP are only needed for an early stage of the reaction that results in Sec17p release. Sec17p and Sec18p actions precede, and are needed for, the step employing the Ras-like GTPase Ypt7p. Sec18p-driven release of Sec17p can even precede vacuole docking, as it can occur prior to mixing of vacuoles and is insensitive to vacuole concentration. Sec17p and Sec18p thus may function in a predocking stage of the reaction, rather than in bilayer fusion per se.
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Cites
Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes
Latterich, M., Fröhlich, K.-U., & Schekman, R. (1995) · Cell · doi:10.1016/0092-8674(95)90268-6 · Cited by 388
Cited by
SNAREs — engines for membrane fusion
Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635
Membrane Fusion: Grappling with SNARE and SM Proteins
Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027
Membrane Fusion and Exocytosis
Jahn, R., & Südhof, T. C. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.863 · Cited by 1,259
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
Südhof, T. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.022 · Cited by 1,197
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Metadata
- Authors
- Mayer, A., Wickner, W., & Haas, A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-04
- Volume
- 85
- Issue
- 1
- Pages
- 83-94
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2014222535
- Cited by
- 577
- References
- 1
- FWCI
- 23.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Mayer, A., Wickner, W., & Haas, A. (1996). Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles. Cell. https://doi.org/10.1016/s0092-8674(00)81084-3
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