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Direct and Long-Range Action of a DPP Morphogen Gradient
Open accessAbstract
During development of the Drosophila wing, the decapentaplegic (dpp) gene is expressed in a stripe of cells along the anteroposterior compartment boundary and gives rise to a secreted protein that exerts a long-range organizing influence on both compartments. Using clones of cells that express DPP, or in which DPP receptor activity has been constitutively activated or abolished, we show that DPP acts directly and at long range on responding cells, rather than by proxy through the short-range induction of other signaling molecules. Further, we show that two genes, optomotor-blind and spalt are transcriptionally activated at different distances from DPP-secreting cells and provide evidence that these genes respond to different threshold concentrations of DPP protein. We propose that DPP acts as a gradient morphogen during wing development.
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Cites
The chemical basis of morphogenesis
Turing, A. M. (1952) · Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences · doi:10.1098/rstb.1952.0012 · Cited by 11,733
Francois, V, Solloway, M., O'Neill, J. W., Emery, J., & Bier, E. (1994) · Genes & Development · doi:10.1101/gad.8.21.2602 · Cited by 308
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Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735
Self-citation1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Xie, T., & Spradling, A. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81424-5 · Cited by 668
The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network
Harvey, K., & Tapon, N. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2070 · Cited by 628
Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
Kim, J., Johnson, K., Chen, H. J., Carroll, S., & Laughon, A. (1997) · Nature · doi:10.1038/40906 · Cited by 527
Metadata
- Authors
- Nellen, D., Burke, R., Struhl, G., & Basler, K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 85
- Issue
- 3
- Pages
- 357-368
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2021554803
- Cited by
- 892
- References
- 2
- FWCI
- 30.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nellen, D., Burke, R., Struhl, G., & Basler, K. (1996). Direct and Long-Range Action of a DPP Morphogen Gradient. Cell. https://doi.org/10.1016/s0092-8674(00)81114-9
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