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1 Developmental roles and clinical significance of Hedgehog signaling

McMahon, Andrew P, Ingham, Philip W, Tabin, Clifford J·2003·Current Topics in Developmental Biology
DOI 10.1016/s0070-2153(03)53002-2
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Abstract

Cell signaling plays a key role in the development of all multicellular organisms. Numerous studies have established the importance of Hedgehog signaling in a wide variety of regulatory functions during the development of vertebrate and invertebrate organisms. Several reviews have discussed the signaling components in this pathway, their various interactions, and some of the general principles that govern Hedgehog signaling mechanisms. This review focuses on the developing systems themselves, providing a comprehensive survey of the role of Hedgehog signaling in each of these. We also discuss the increasing significance of Hedgehog signaling in the clinical setting.

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Metadata

Authors
McMahon, A. P., Ingham, P. W., & Tabin, C. J.
Venue
Current Topics in Developmental Biology
Publisher
Elsevier
Published
2003
Pages
1-114
ISSN
0070-2153
DOI
10.1016/s0070-2153(03)53002-2
Cited by
772
References
10
Language
en

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