The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
Open accessAbstract
Xenopus blastula cells activate different mesodermal genes as a concentration-dependent response to activin, which behaves like a morphogen. To understand how cells recognize morphogen concentration, we have bound naturally labeled activin to cells and related this to choice of gene activation. We find that the increasing occupancy of a single receptor type can cause cells to switch gene expression. Cells sense ligand concentration by the absolute number of occupied receptors per cell (100 and 300 molecules of bound activin induce Xbra and Xgsc, respectively, i.e., 2% and 6% of the total receptors) and not by a ratio of occupied to unoccupied receptors. The long duration of occupancy explains a previously described ratchet effect. Our results suggest a new concept of morphogen gradient formation and interpretation that is particularly well suited to the needs of early development.
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“Thus, like activindependent receptor signaling in Xenopus (Dyson and Gurdon 1998), it appears that cells in the early embryo are responsive to different levels of activated Toll receptor.”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Dyson and Gurdon 1998
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Cites
LIGAND: A versatile computerized approach for characterization of ligand-binding systems
Munson, P. J., & Rodbard, D. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90515-1 · Cited by 8,373
Positional information and the spatial pattern of cellular differentiation
Wolpert, L. (1969) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(69)80016-0 · Cited by 3,091
Mechanism of activation of the TGF-β receptor
Wrana, J. L., Attisano, L., Wieser, R., Ventura, F., & Massagué, J. (1994) · Nature · doi:10.1038/370341a0 · Cited by 2,340
Sonic hedgehog mediates the polarizing activity of the ZPA
Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. J. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,285
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
Nakao, A., Afrakhte, M., Morn, A., Nakayama, T., Christian, J. L., Heuchel, R. L., Itoh, S., Kawabata, M., Heldin, N., Heldin, C., et al. (1997) · Nature · doi:10.1038/39369 · Cited by 1,796
Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y., Grinnell, B. W., Richardson, M. A., Topper, J. N., Gimbrone, M. A., Wrana, J. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80303-7 · Cited by 1,322
Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling
Ericson, J., Rashbass, P., Schedl, A., Brenner‐Morton, S., Kawakami, A., van Heyningen, V., Jessell, T. M., & Briscoe, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80323-2 · Cited by 1,044
T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds
Viola, A., & Lanzavecchia, A. (1996) · Science · doi:10.1126/science.273.5271.104 · Cited by 1,031
Smith, J. C., Price, B. M. J., Green, J. B. A., Weigel, D., & Herrmann, B. G. (1991) · Cell · doi:10.1016/0092-8674(91)90573-h · Cited by 971
Dual Roles for Patched in Sequestering and Transducing Hedgehog
Chen, Y., & Struhl, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81374-4 · Cited by 902
Research works printed but not linked: 2
- Gurdon, 1976, Injected nuclei in frog oocytes, J. Embryol. Exp. Morphol., 36, 523
- Koenig, 1996, Intracellular trafficking of the muscarinic acetylcholine receptor, Mol. Pharmacol., 49, 351
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Smad transcription factorsPreprint
Massagué, J., Seoane, J., & Wotton, D. (2005) · Genes & Development · doi:10.1101/gad.1350705 · Cited by 2,519
Massagué, J. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043051 · Cited by 1,925
Out of Eden: Stem Cells and Their Niches
Watt, F. M., & Hogan, A. B. L. M. (2000) · Science · doi:10.1126/science.287.5457.1427 · Cited by 1,754
TGFβ–SMAD signal transduction: molecular specificity and functional flexibility
Schmierer, B., & Hill, C. S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2297 · Cited by 1,258
New insights into TGF-β–Smad signalling
ten Dijke, P., & Hill, C. S. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.03.008 · Cited by 1,176
Metadata
- Authors
- Dyson, S., & Gurdon, J. B.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Gurdon, J.B
- ORCID
- Gurdon, J.B
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 93
- Issue
- 4
- Pages
- 557-568
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2110126772
- Cited by
- 204
- References
- 53
- Citations by year
- 2026: 1 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 2 · 2017: 2 · 2016: 7 · 2015: 4 · 2014: 5 · 2013: 7 · 2012: 3
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- activin, morphogen gradients, receptor occupancy, Xbra, ratchet effect, gene expression switching, early embryonic development
- MeSH terms
- Brachyury Protein, Animals, Blastocyst, DNA-Binding Proteins, Fetal Proteins, Inhibins, Ligands, Oligopeptides, Oocytes, Peptides, Repressor Proteins, RNA, Messenger, Transcription Factors, Xenopus, Signal Transduction, Transcriptional Activation, Receptors, Growth Factor, Homeodomain Proteins, Gene Expression Regulation, Developmental, T-Box Domain Proteins, Activins, Activin Receptors, Goosecoid Protein
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