The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
cul-1 Is Required for Cell Cycle Exit in C. elegans and Identifies a Novel Gene Family
Open accessAbstract
The gene cul-1 (formerly lin-19) is a negative regulator of the cell cycle in C. elegans. Null mutations cause hyperplasia of all tissues. cul-1 is required for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway. Moreover, the mutant phenotype suggests that G1-to-S phase progression is accelerated, overriding mechanisms for mitotic arrest and producing abnormally small cells. Significantly, diverse aspects of cell fate and differentiation are unaffected in cul-1 mutants. cul-1 represents a conserved family of genes, designated cullins, with at least five members in nematodes, six in humans, and three in budding yeast.
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Cites
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Cited by
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Metadata
- Authors
- Kipreos, E. T., Lander, L. E., Wing, J. P., He, W. W., & Hedgecock, E. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 85
- Issue
- 6
- Pages
- 829-839
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2088966640
- Cited by
- 448
- References
- 43
- FWCI
- 16.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kipreos, E. T., Lander, L. E., Wing, J. P., He, W. W., & Hedgecock, E. M. (1996). cul-1 Is Required for Cell Cycle Exit in C. elegans and Identifies a Novel Gene Family. Cell. https://doi.org/10.1016/s0092-8674(00)81267-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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