The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA
Open accessAbstract
The crystal structure of the human DNA polymerase delta processivity factor PCNA (proliferating cell nuclear antigen) complexed with a 22 residue peptide derived from the C-terminus of the cell-cycle checkpoint protein p21(WAF1/CIP1) has been determined at 2.6 angstrom resolution. p21 binds to PCNA in a 1:1 stoichiometry with an extensive array of interactions that include the formation of a beta sheet with the interdomain connector loop of PCNA. An intact trimeric ring is maintained in the structure of the p21-PCNA complex, with a central hole available for DNA interaction. The ability of p21 to inhibit the action of PCNA is therefore likely to be due to its masking of elements on PCNA that are required for the binding of other components of the polymerase assembly.
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Citations
Cites
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
Waga, S., Hannon, G. J., Beach, D., & Stillman, B. (1994) · Nature · doi:10.1038/369574a0 · Cited by 1,655
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M., & Smith, J. R. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1063 · Cited by 1,351
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
Waldman, T., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1996) · Nature · doi:10.1038/381713a0 · Cited by 728
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1
Luo, Y., Hurwitz, J., & Massagué, J. (1995) · Nature · doi:10.1038/375159a0 · Cited by 549
Self-citationSeparate domains of p21 involved in the inhibition of Cdk kinase and PCNA
Chen, J., Jackson, P. K., Kirschner, M. W., & Dutta, A. (1995) · Nature · doi:10.1038/374386a0 · Cited by 548
Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21
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Self-citationPodust, V. N., Podust, L. M., Goubin, F., Ducommun, B., & Huebscher, U. (1995) · Biochemistry · doi:10.1021/bi00027a039 · Cited by 124
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Cited by
PCNA, the Maestro of the Replication Fork
Moldovan, G.-L., Pfander, B., & Jentsch, S. (2007) · Cell · doi:10.1016/j.cell.2007.05.003 · Cited by 1,796
“Cell 129, May 18, 2007 ©2007 Elsevier Inc. 667 bic plug, docking into a hydrophobic pocket of PCNA buried under the interdomain connecting loop (Bruning and Shamoo, 2004; Gulbis et al., 1996).”
Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA
Kannouche, P. L., Wing, J., & Lehmann, A. R. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00259-x · Cited by 845
Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation
Strzalka, W., & Ziemienowicz, A. (2011) · Annals of Botany · doi:10.1093/aob/mcq243 · Cited by 784
Hübscher, U., Maga, G., & Spadari, S. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150041 · Cited by 691
Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair
Gillet, L. C. J., & Schärer, O. D. (2006) · Chemical Reviews · doi:10.1021/cr040483f · Cited by 642
Metadata
- Authors
- Gulbis, J. M., Kelman, Z., Hurwitz, J., O'Donnell, M., & Kuriyan, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-10
- Volume
- 87
- Issue
- 2
- Pages
- 297-306
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2116537286
- Cited by
- 804
- References
- 8
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81347-1
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- Gulbis, J. M., Kelman, Z., Hurwitz, J., O'Donnell, M., & Kuriyan, J. (1996). Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA. Cell. https://doi.org/10.1016/s0092-8674(00)81347-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
