Eukaryotic DNA Polymerases

DNA Replication in Eukaryotic Cells

Bell, S. P., & Dutta, A. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135425 · Cited by 2,065 · see citing works

Quality Control by DNA Repair

Lindahl, T. L., & Wood, R. D. (1999) · Science · doi:10.1126/science.286.5446.1897 · Cited by 1,489 · see citing works

The Cell as a Collection of Protein Machines: Preparing the Next Generation of Molecular Biologists

Alberts, B. (1998) · Cell · doi:10.1016/s0092-8674(00)80922-8 · Cited by 1,411 · see citing works

Telomere states and cell fates

Blackburn, E. H. (2000) · Nature · doi:10.1038/35040500 · Cited by 1,372 · see citing works

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292 · see citing works

DNA Replication Fidelity

Kunkel, T. A., & Bebenek, K. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.497 · Cited by 1,003 · see citing works

Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

Krishna, T. S. R., Kong, X., Gary, S. L., Burgers, P., & Kuriyan, J. (1994) · Cell · doi:10.1016/0092-8674(94)90014-0 · Cited by 902 · see citing works

The Y-Family of DNA Polymerases

Ohmori, H., Friedberg, E. C., Fuchs, R. P., Goodman, M. F., Hanaoka, F., Hinkle, D. C., Kunkel, T. A., Lawrence, C. W., Livneh, Z., Nohmi, T., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00278-7 · Cited by 882 · see citing works

Eukaryotic DNA mismatch repair

Kolodner, R. D., & Marsischky, G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80013-6 · Cited by 861 · see citing works

DNA Polymerases: Structural Diversity and Common Mechanisms

Steitz, T. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17395 · Cited by 848 · see citing works

Mammalian DNA nucleotide excision repair reconstituted with purified protein components

Aboussekhra, A., Biggerstaff, M., Shivji, M. K. K., Vilpo, J. A., Moncollin, V., Podust, V. N., Protić, M., Hübscher, U., Egly, J.-M., & Wood, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90289-9 · Cited by 837 · see citing works

Requirement of mammalian DNA polymerase-β in base-excision repair

Sobol, R. W., Horton, J. K., Kühn, R., Gu, H., Singhal, R. K., Prasad, R., Rajewsky, K., & Wilson, S. H. (1996) · Nature · doi:10.1038/379183a0 · Cited by 834 · see citing works

THE DNA REPLICATION FORK IN EUKARYOTIC CELLS

Waga, S., & Stillman, B. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.721 · Cited by 814 · see citing works

Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA

Gulbis, J. M., Kelman, Z., Hurwitz, J., O’Donnell, M. E., & Kuriyan, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81347-1 · Cited by 805 · see citing works

Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp

Kong, X., Onrust, R., O’Donnell, M. E., & Kuriyan, J. (1992) · Cell · doi:10.1016/0092-8674(92)90445-i · Cited by 754 · see citing works

Efficient Bypass of a Thymine-Thymine Dimer by Yeast DNA Polymerase, Polη

Johnson, R. E., Prakash, S., & Prakash, L. (1999) · Science · doi:10.1126/science.283.5404.1001 · Cited by 736 · see citing works

Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes

Goodman, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.083101.124707 · Cited by 727 · see citing works

STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP

Pelletier, H., Sawaya, M. R., Kumar, A., Wilson, S. H., & Kraut, J. (1994) · Worldwide Protein Data Bank · doi:10.2210/pdb2bpf/pdb · Cited by 694 · see citing works

Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ

Nelson, J. R., Lawrence, C. W., & Hinkle, D. C. (1996) · Science · doi:10.1126/science.272.5268.1646 · Cited by 654 · see citing works

Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions

Johnson, R. E., Washington, M. T., Haracska, L., Prakash, S., & Prakash, L. (2000) · Nature · doi:10.1038/35023030 · Cited by 632 · see citing works

FUNCTION AND STRUCTURE RELATIONSHIPS IN DNA POLYMERASES

Joyce, C. M., & Steitz, T. A. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.004021 · Cited by 620 · see citing works

Structures of Ternary Complexes of Rat DNA Polymerase β, a DNA Template-Primer, and ddCTP

Pelletier, H., Sawaya, M. R., Kumar, A., Wilson, S. H., & Kraut, J. (1994) · Science · doi:10.1126/science.7516580 · Cited by 598 · see citing works

A mechanism for all polymerases

Steitz, T. A. (1998) · Nature · doi:10.1038/34542 · Cited by 597 · see citing works

Compilation, alignment, and phylogenetic relationships of DNA polymerases

Braithwaite, D. K., & Ito, J. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.4.787 · Cited by 586 · see citing works

Deoxycytidyl transferase activity of yeast REV1 protein

Nelson, J. R., Lawrence, C. W., & Hinkle, D. C. (1996) · Nature · doi:10.1038/382729a0 · Cited by 573 · see citing works

CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY

Johnson, K. A. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.003345 · Cited by 560 · see citing works

Structure of the Replicating Complex of a Pol α Family DNA Polymerase

Franklin, M. C., Wang, J., & Steitz, T. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00367-1 · Cited by 538 · see citing works

Molecular mechanisms of DNA double-strand break repair

Kanaar, R., Hoeijmakers, J. H. J., & van Gent, D. C. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01383-x · Cited by 526 · see citing works

Crystal Structure of Rat DNA Polymerase β: Evidence for a Common Polymerase Mechanism

Sawaya, M. R., Pelletier, H., Kumar, A., Wilson, S. H., & Kraut, J. (1994) · Science · doi:10.1126/science.7516581 · Cited by 469 · see citing works

Xeroderma pigmentosum variant (XP‐V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity

Masutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S., & Hanaoka, F. (1999) · The EMBO Journal · doi:10.1093/emboj/18.12.3491 · Cited by 434 · see citing works

DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

Zeng, X., Winter, D. B., Kasmer, C., Kraemer, K. H., Lehmann, A. R., & Gearhart, P. J. (2001) · Nature Immunology · doi:10.1038/88740 · Cited by 420 · see citing works

Reconstitution of complete SV40 DNA replication with purified replication factors.

Waga, S., Bauer, G. A., & Stillman, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34146-7 · Cited by 404 · see citing works

DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint

Navas, T. A., Zhou, Z. Y., & Elledge, S. J. (1995) · Cell · doi:10.1016/0092-8674(95)90448-4 · Cited by 403 · see citing works

Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes

Brautigam, C. A., & Steitz, T. A. (1998) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(98)80010-9 · Cited by 377 · see citing works

Low fidelity DNA synthesis by human DNA polymerase-η

Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., & Kunkel, T. A. (2000) · Nature · doi:10.1038/35010014 · Cited by 372 · see citing works

Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase

Pellicioli, A., Lucca, C., Liberi, G., Marini, F., Lopes, M., Plevani, P., Romano, A., Fiore, P. P. D., & Foiani, M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6561 · Cited by 369 · see citing works

Building a Replisome from Interacting Pieces

Shamoo, Y. E., & Steitz, T. A. (1999) · Cell · doi:10.1016/s0092-8674(00)81647-5 · Cited by 363 · see citing works

Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η

Haracska, L., Yu, S.-L., Johnson, R. E., Prakash, L., & Prakash, S. (2000) · Nature Genetics · doi:10.1038/78169 · Cited by 349 · see citing works

Roles of yeast DNA polymerases δ and ζ and of Rev1 in the bypass of abasic sitesPreprint

Haracska, L., Unk, I., Johnson, R. E., Johansson, E., Burgers, P., Prakash, S., & Prakash, L. (2001) · Genes & Development · doi:10.1101/gad.882301 · Cited by 347 · see citing works

Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η

Trincão, J., Johnson, R. E., Escalante, C. R., Prakash, S., Prakash, L., & Aggarwal, A. K. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00306-9 · Cited by 344 · see citing works

Polymerases and the Replisome: Machines within Machines

Baker, T. A., & Bell, S. P. (1998) · Cell · doi:10.1016/s0092-8674(00)80923-x · Cited by 344 · see citing works

DNA Primases

Frick, D. N., & Richardson, C. C. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.39 · Cited by 344 · see citing works

The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity

Sobol, R. W., Prasad, R., Evenski, A. J., Baker, A. E., Yang, X., Horton, J. K., & Wilson, S. H. (2000) · Nature · doi:10.1038/35015598 · Cited by 343 · see citing works

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein.

Qi, H., & Zakian, V. A. (2000) · Europe PMC (PubMed Central) · Cited by 319 · see citing works

polι, a remarkably error-prone human DNA polymerase

Tissier, A., McDonald, J. P., Frank, E. G., & Woodgate, R. (2000) · Genes & Development · doi:10.1101/gad.14.13.1642 · Cited by 315 · see citing works

Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro

Zhang, Y. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.21.4138 · Cited by 303 · see citing works

Somatic mutation hotspots correlate with DNA polymerase η error spectrum

Rogozin, I. B., Pavlov, Y. I., Bebenek, K., Matsuda, T., & Kunkel, T. A. (2001) · Nature Immunology · doi:10.1038/88732 · Cited by 298 · see citing works

Error-prone bypass of certain DNA lesions by the human DNA polymerase κPreprint

Ohashi, E., Ogi, T., Kusumoto, R., Iwai, S., Masutani, C., Hanaoka, F., & Ohmori, H. (2000) · Genes & Development · doi:10.1101/gad.14.13.1589 · Cited by 279 · see citing works

Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cellsPreprint

Kannouche, P., Broughton, B. C., Volker, M., Hanaoka, F., Mullenders, L. H. F., & Lehmann, A. R. (2001) · Genes & Development · doi:10.1101/gad.187501 · Cited by 278 · see citing works

DNA Polymerase ε Catalytic Domains Are Dispensable for DNA Replication, DNA Repair, and Cell Viability

Kesti, T., Flick, K. M., Keränen, S., Syväoja, J. E., & Wittenberg, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80361-5 · Cited by 276 · see citing works

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase α and the telomerase-associated Est1 proteinPreprint

Qi, H., & Zakian, V. A. (2000) · Genes & Development · doi:10.1101/gad.14.14.1777 · Cited by 276 · see citing works

Mammalian base excision repair and DNA polymerase beta

Wilson, S. H. (1998) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(98)00002-0 · Cited by 275 · see citing works

Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint.

Araki, H., Leem, S., Phongdara, A., & Sugino, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11791 · Cited by 273 · see citing works

REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase

Morrison, A., Christensen, R. B., Alley, J., Beck, A. K., Bernstine, E. G., Lemontt, J. F., & Lawrence, C. W. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.10.5659-5667.1989 · Cited by 271 · see citing works

DNA polymerase mu (Pol μ), homologous to TdT, could act as a DNA mutator in eukaryotic cells

Domı́nguez, O., Ruiz, J. F., de Lera, T. L., García–Díaz, M., González, M. A., Kirchhoff, T., Martínez‐A, C., Bernad, A., & Blanco, L. (2000) · The EMBO Journal · doi:10.1093/emboj/19.7.1731 · Cited by 268 · see citing works

DNA polymerase lambda (Pol λ), a novel eukaryotic DNA polymerase with a potential role in meiosis 1 1Edited by M. Yaniv

García–Díaz, M., Domı́nguez, O., López-Fernández, L. A., de Lera, L. T., Sanı́ger, M. L., Ruiz, J. F., Párraga, M., Garcı́a-Ortiz, M. J., Kirchhoff, T., del Mazo, J., et al. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4005 · Cited by 264 · see citing works

Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes

Papavasiliou, F. N., & Schatz, D. G. (2000) · Nature · doi:10.1038/35041599 · Cited by 261 · see citing works

Double-Strand Break Repair in Yeast Requires Both Leading and Lagging Strand DNA Polymerases

Holmes, A. M., & Haber, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80554-1 · Cited by 256 · see citing works

Proliferating cell nuclear antigen: More than a clamp for DNA polymerases

Jónsson, Z. O., & Hübscher, U. (1997) · BioEssays · doi:10.1002/bies.950191106 · Cited by 248 · see citing works

Crystal Structure of the δ′ Subunit of the Clamp-Loader Complex of E. coli DNA Polymerase III

Guenther, B. D., Onrust, R., Šali, A., O’Donnell, M. E., & Kuriyan, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80417-1 · Cited by 247 · see citing works

A plethora of lesion-replicating DNA polymerasesPreprint

Woodgate, R. (1999) · Genes & Development · doi:10.1101/gad.13.17.2191 · Cited by 246 · see citing works

Identification of 5′-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair in vitro

Longley, M. J., Prasad, R., Srivastava, D., Wilson, S. H., & Copeland, W. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12244 · Cited by 227 · see citing works

Fidelity and Processivity of DNA Synthesis by DNA Polymerase κ, the Product of the Human DINB1 Gene

Ohashi, E., Bębenek, K., Matsuda, T., Feaver, W. J., Gerlach, V. L., Friedberg, E. C., Ohmori, H., & Kunkel, T. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005309200 · Cited by 225 · see citing works

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase β

Sugo, N., Aratani, Y., Nagashima, Y., Kubota, Y., & Koyama, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1397 · Cited by 221 · see citing works

Eukaryotic DNA polymerases, a growing family

Hübscher, U., Nasheuer, H., & Syväoja, J. E. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01523-6 · Cited by 220 · see citing works

Role of DNA Polymerase β in the Excision Step of Long Patch Mammalian Base Excision Repair

Dianov, G. L., Prasad, R., Wilson, S. H., & Bohr, V. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.13741 · Cited by 217 · see citing works

The internal workings of a DNA polymerase clamp‐loading machine

Turner, J., Hingorani, M., Kelman, Z., & O’Donnell, M. E. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.771 · Cited by 215 · see citing works

FEN1 Stimulation of DNA Polymerase β Mediates an Excision Step in Mammalian Long Patch Base Excision Repair

Prasad, R., Dianov, G. L., Bohr, V. A., & Wilson, S. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4460 · Cited by 212 · see citing works

Activation of the DNA Replication Checkpoint Through RNA Synthesis by Primase

Michael, W. M., Ott, R., Fanning, E., & Newport, J. W. (2000) · Science · doi:10.1126/science.289.5487.2133 · Cited by 206 · see citing works

The Translesion DNA Polymerase ζ Plays a Major Role in Ig and bcl-6 Somatic Hypermutation

Zan, H., Komori, A., Li, Z., Cerutti, A., Schaffer, A., Flajnik, M. F., Diaz, M., & Casali, P. (2001) · Immunity · doi:10.1016/s1074-7613(01)00142-x · Cited by 204 · see citing works

Misinsertion and bypass of thymine–thymine dimers by human DNA polymerase ι

Tissier, A., Frank, E. G., McDonald, J. P., Iwai, S., Hanaoka, F., & Woodgate, R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.19.5259 · Cited by 202 · see citing works

The 3′→5′ Exonucleases of DNA Polymerases δ and ɛ and the 5′→3′ Exonuclease Exo1 Have Major Roles in Postreplication Mutation Avoidance in Saccharomyces cerevisiae

Tran, H. T., Gordenin, D. A., & Resnick, M. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2000 · Cited by 201 · see citing works

Interaction with PCNA Is Essential for Yeast DNA Polymerase η Function

Haracska, L., Kondratick, C. M., Unk, I., Prakash, S., & Prakash, L. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00319-7 · Cited by 198 · see citing works

5'-Deoxyribose Phosphate Lyase Activity of Human DNA Polymerase ɩ in Vitro

Bębenek, K., Tissier, A., Frank, E. G., McDonald, J. P., Prasad, R., Wilson, S. H., Woodgate, R., & Kunkel, T. A. (2001) · Science · doi:10.1126/science.1058386 · Cited by 197 · see citing works

Mammalian base excision repair by DNA polymerases δ and ε

Stucki, M., Pascucci, B., Parlanti, E., Fortini, P., Wilson, S. H., Hübscher, U., & Eugenia Dogliotti, Y. (1998) · Oncogene · doi:10.1038/sj.onc.1202001 · Cited by 192 · see citing works

Efficient Repair of Abasic Sites in DNA by Mitochondrial Enzymes

Pinz, K. G., & Bogenhagen, D. F. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1257 · Cited by 190 · see citing works

Pol κ: A DNA Polymerase Required for Sister Chromatid Cohesion

Wang, Z., Castaño, I., Peñas, A. D. L., Adams, C., & Christman, M. F. (2000) · Science · doi:10.1126/science.289.5480.774 · Cited by 186 · see citing works

Dpb11 Controls the Association between DNA Polymerases α and ɛ and the Autonomously Replicating Sequence Region of Budding Yeast

Masumoto, H., Sugino, A., & Araki, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2809-2817.2000 · Cited by 184 · see citing works

Novel Human and Mouse Homologs of Saccharomyces cerevisiae DNA Polymerase η

McDonald, J. P., Rapić-Otrin, V., Epstein, J. A., Broughton, B. C., Wang, X., Lehmann, A. R., Wolgemuth, D. J., & Woodgate, R. (1999) · Genomics · doi:10.1006/geno.1999.5906 · Cited by 183 · see citing works

Fission Yeast Eso1p Is Required for Establishing Sister Chromatid Cohesion during S Phase

Tanaka, K., Yonekawa, T., Kawasaki, Y., Kai, M., Furuya, K., Iwasaki, M., Murakami, H., Yanagida, M., & Okayama, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3459-3469.2000 · Cited by 182 · see citing works

The human REV1 gene codes for a DNA template-dependent dCMP transferase

Lin, W., Xin, H., Zhang, Y., Wu, X., Yuan, F., & Wang, Z. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.22.4468 · Cited by 180 · see citing works

Structure and Processivity of Two Forms of Saccharomyces cerevisiae DNA Polymerase δ

Burgers, P., & Gerik, K. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19756 · Cited by 179 · see citing works

The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light

Gibbs, P., Wang, X.-D., Li, Z., McManus, T. P., McGregor, W. G., Lawrence, C. W., & Maher, V. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4186 · Cited by 175 · see citing works

Disruption of the developmentally regulated Rev3l gene causes embryonic lethality

Wittschieben, J. P., Shivji, M. K. K., Lalani, E., Jacobs, M. A., Marini, F., Gearhart, P. J., Rosewell, I. R., Stamp, G., & Wood, R. D. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00725-9 · Cited by 173 · see citing works

Defective DNA polymerase-δ proofreading causes cancer susceptibility in mice

Goldsby, R. E., Lawrence, N. A., Hays, L. E., Olmsted, E. A., Chen, X., Singh, M., & Preston, B. D. (2001) · Nature Medicine · doi:10.1038/88963 · Cited by 171 · see citing works

Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage

Moarefi, I., Jeruzalmi, D., Turner, J., O’Donnell, M. E., & Kuriyan, J. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3511 · Cited by 169 · see citing works

Two novel human and mouse DNA polymerases of the polX family

Aoufouchi, S. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.18.3684 · Cited by 166 · see citing works

Clamping down on clamps and clamp loaders

Mossi, R., & Hübscher, U. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.254209.x · Cited by 164 · see citing works

Mutations in Yeast Proliferating Cell Nuclear Antigen Define Distinct Sites for Interaction with DNA Polymerase δ and DNA Polymerase ε

Eissenberg, J. C., Ayyagari, R., Gomes, X. V., & Burgers, P. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6367 · Cited by 162 · see citing works

Disruption of the Rev3l-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality

Esposito, G., Godin, I., Klein, U., Yaspo, M., Cumano, A., & Rajewsky, K. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00726-0 · Cited by 161 · see citing works

Crystal Structure and Deletion Analysis Show that the Accessory Subunit of Mammalian DNA Polymerase γ, PolγB, Functions as a Homodimer

Carrodeguas, J. A., Theis, K., Bogenhagen, D. F., & Kisker, C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00153-8 · Cited by 150 · see citing works

Specificity of DNA Lesion Bypass by the Yeast DNA Polymerase η

Yuan, F., Zhang, Y., Rajpal, D. K., Wu, X., Guo, D., Wang, M., Taylor, J., & Wang, Z. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.8233 · Cited by 146 · see citing works

Response of human DNA polymerase iota to DNA lesions

Zhang, Y. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.4.928 · Cited by 146 · see citing works

Functional roles of DNA polymerases beta and gamma.

Hübscher, U., Kuenzle, C. C., & Spadari, S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.5.2316 · Cited by 140 · see citing works

Replication past O 6 -Methylguanine by Yeast and Human DNA Polymerase η

Haracska, L., Prakash, S., & Prakash, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8001-8007.2000 · Cited by 139 · see citing works

DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiae.

Wang, Z., Wu, X., & Friedberg, E. C. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.2.1051 · Cited by 138 · see citing works

Eukaryotic DNA primase

Arezi, B., & Kuchta, R. D. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01680-7 · Cited by 137 · see citing works

Schizosaccharomyces pombe Cells Lacking the Amino-Terminal Catalytic Domains of DNA Polymerase Epsilon Are Viable but Require the DNA Damage Checkpoint Control

Feng, W., & D’Urso, G. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.14.4495-4504.2001 · Cited by 125 · see citing works

DNA Polymerase ζ Introduces Multiple Mutations when Bypassing Spontaneous DNA Damage in Saccharomyces cerevisiae

Harfe, B. D., & Jinks-Robertson, S. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00145-3 · Cited by 120 · see citing works

DNA Damage Control by Novel DNA Polymerases: Translesion Replication and Mutagenesis

Livneh, Z. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100019200 · Cited by 119 · see citing works

Cloning and Chromosomal Mapping of the Human DNA Polymerase θ (POLQ), the Eighth Human DNA Polymerase

Sharief, F. S., Vojta, P. J., Ropp, P. A., & Copeland, W. C. (1999) · Genomics · doi:10.1006/geno.1999.5843 · Cited by 118 · see citing works

A role for DNA primase in coupling DNA replication to DNA damage response

Marini, F., Pellicioli, A., Paciotti, V., Lucchini, G., Plevani, P., Stern, D. F., & Foiani, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.3.639 · Cited by 116 · see citing works

DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast

D’Urso, G., Grallert, B., & Nurse, P. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.9.3109 · Cited by 116 · see citing works

DNA polymerase epsilon may be dispensable for SV40‐ but not cellular‐DNA replication.

Zlotkin, T., Kaufmann, G., Jiang, Y. Q., Lee, M. Y., Uitto, L., Syväoja, J. E., Dornreiter, I., Fanning, E., & Nethanel, T. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00583.x · Cited by 115 · see citing works

Human DNA polymerase kappa synthesizes DNA with extraordinarily low fidelity

Zhang, Y. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.21.4147 · Cited by 109 · see citing works

The Function of DNA Polymerase α at Telomeric G Tails Is Important for Telomere Homeostasis

Martin, A. A., Dionne, I., Wellinger, R. J., & Holm, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.786-796.2000 · Cited by 109 · see citing works

Polymerase η deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair

Limoli, C. L., Giedzinski, E., Morgan, W. F., & Cleaver, J. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130182897 · Cited by 98 · see citing works

Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p

Lawrence, C. W., & Maher, V. M. (2001) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0001 · Cited by 95 · see citing works

Mice reconstituted with DNA polymerase β-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

Esposito, G., Texidó, G., Betz, U. A. K., Gu, H., Müller, W., Klein, U., & Rajewsky, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1166 · Cited by 93 · see citing works

The Role of 3′-5′ Exonucleolytic Proofreading and Mismatch Repair in Yeast Mitochondrial DNA Error Avoidance

Vanderstraeten, S., van den Brûle, S., Hu, J., & Foury, F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23690 · Cited by 91 · see citing works

Lagging strand DNA synthesis by calf thymus DNA polymerases α, β, δ and ε in the presence of auxiliary proteins

Podust, V. N., & Hübscher, U. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.4.841 · Cited by 91 · see citing works

Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeast.

Sugimoto, K., Shimomura, T., Hashimoto, K., Araki, H., Sugino, A., & Matsumoto, K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7048 · Cited by 91 · see citing works

A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells.

Fotedar, R., Mossi, R., Fitzgerald, P., Rousselle, T., Maga, G., Brickner, H., Messier, H., Kasibhatla, S., Hübscher, U., & Fotedar, A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00815.x · Cited by 90 · see citing works

DNA polymerase switching: I. Replication factor C displaces DNA polymerase α prior to PCNA loading

Maga, G., Stucki, M., Spadari, S., & Hübscher, U. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3394 · Cited by 89 · see citing works

Identification and Cloning of Two Histone Fold Motif-containing Subunits of HeLa DNA Polymerase ε

Li, Y., Pursell, Z. F., & Linn, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002548200 · Cited by 88 · see citing works

Expression, Purification, and Initial Kinetic Characterization of the Large Subunit of the Human Mitochondrial DNA Polymerase

Graves, S. W., Johnson, A. A., & Johnson, K. A. (1998) · Biochemistry · doi:10.1021/bi972685u · Cited by 87 · see citing works

The δ Subunit of DNA Polymerase III Holoenzyme Serves as a Sliding Clamp Unloader in Escherichia coli

Leu, F. P., Hingorani, M., Turner, J., & O’Donnell, M. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005495200 · Cited by 87 · see citing works

Cell Cycle-Dependent Regulation of Human DNA Polymerase α-Primase Activity by Phosphorylation

Voitenleitner, C., Rehfuess, C., Hilmes, M. A., O’Rear, L., Liao, P., Gage, D. A., Ott, R., Nasheuer, H., & Fanning, E. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.646 · Cited by 86 · see citing works

The DNA polymerase α-primase complex couples DNA replication, cell-cycle progression and DNA-damage response

Foiani, M., Lucchini, G., & Plevani, P. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01109-2 · Cited by 85 · see citing works

Review

Hindges, R., & Hübscher, U. (1997) · Biological Chemistry · doi:10.1515/bchm.1997.378.5.345 · Cited by 84 · see citing works

Structure and function of the fourth subunit (Dpb4p) of DNA polymerase varepsilon in Saccharomyces cerevisiae

Ohya, T. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.20.3846 · Cited by 84 · see citing works

Characterization of a Catalytically Slow AP Lyase Activity in DNA Polymerase γ and Other Family A DNA Polymerases

Pinz, K. G., & Bogenhagen, D. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12509 · Cited by 81 · see citing works

Replication Factor C Interacts with the C-terminal Side of Proliferating Cell Nuclear Antigen

Mossi, R., Jónsson, Z. O., Allen, B. L., Hardin, S. H., & Hübscher, U. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.3.1769 · Cited by 81 · see citing works

Schizosaccharomyces pombe cdc 20 + encodes DNA polymerase ɛ and is required for chromosomal replication but not for the S phase checkpoint

D’Urso, G., & Nurse, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12491 · Cited by 81 · see citing works

Isolation and identification of the third subunit of mammalian DNA polymerase by PCNA-affinity chromatography of mouse FM3A cell extracts

Hughes, P., Tratner, I., Ducoux‐Petit, M., Piard, K., & Baldacci, G. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.10.2108 · Cited by 78 · see citing works

DNA polymerase δ isolated from Schizosaccharomyces pombe contains five subunits

Zuo, S., Gibbs, E., Kelman, Z., Wang, T. S. ‐., O’Donnell, M. E., MacNeill, S. A., & Hurwitz, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11244 · Cited by 77 · see citing works

Proofreading of DNA Polymerase η-dependent Replication Errors

Bebenek, K., Matsuda, T., Masutani, C., Hanaoka, F., & Kunkel, T. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000690200 · Cited by 76 · see citing works

The RFC2 Gene, Encoding the Third-Largest Subunit of the Replication Factor C Complex, Is Required for an S-Phase Checkpoint in Saccharomyces cerevisiae

Noskov, V. N., Araki, H., & Sugino, A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4914 · Cited by 75 · see citing works

Replication Factor C Disengages from Proliferating Cell Nuclear Antigen (PCNA) upon Sliding Clamp Formation, and PCNA Itself Tethers DNA Polymerase δ to DNA

Podust, V. N., Tiwari, N., Stephan, S. J., & Fanning, E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.48.31992 · Cited by 73 · see citing works

Molecular Architecture of the Mouse DNA Polymerase α-Primase Complex

Mizuno, T., Yamagishi, K., Miyazawa, H., & Hanaoka, F. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7886 · Cited by 72 · see citing works

A Complex Consisting of Human Replication Factor C p40, p37, and p36 Subunits Is a DNA-dependent ATPase and an Intermediate in the Assembly of the Holoenzyme

Cai, J., Gibbs, E., Uhlmann, F., Phillips, B., Yao, N. Y., O’Donnell, M. E., & Hurwitz, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18974 · Cited by 71 · see citing works

Accuracy of lesion bypass by yeast and human DNA polymerase η

Washington, M. T., Johnson, R. E., Prakash, L., & Prakash, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121007298 · Cited by 71 · see citing works

ATP-dependent structural change of the eukaryotic clamp-loader protein, replication factor C

Shiomi, Y., Usukura, J., Masamura, Y., Takeyasu, K., Nakayama, Y., Obuse, C., Yoshikawa, H., & Tsurimoto, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14127 · Cited by 70 · see citing works

Division of labor—sequential ATP hydrolysis drives assembly of a DNA polymerase sliding clamp around DNA

Hingorani, M., Bloom, L. B., Goodman, M. F., & O’Donnell, M. E. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5131 · Cited by 68 · see citing works

DNA polymerase iota and related Rad30–like enzymes

McDonald, J. P., Tissier, A., Frank, E. G., Iwai, S., Hanaoka, F., & Woodgate, R. (2001) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0748 · Cited by 68 · see citing works

DNA replication: enzymology and mechanisms

Kelman, Z., & O’Donnell, M. E. (1994) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80044-9 · Cited by 67 · see citing works

Altered nucleotide misinsertion fidelity associated with polι‐dependent replication at the end of a DNA template

Frank, E. G., Tissier, A., McDonald, J. P., Rapić‐Otrin, V., Zeng, X., Gearhart, P. J., & Woodgate, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2914 · Cited by 62 · see citing works

DNA polymerase mu, a candidate hypermutase?

Ruiz, J. F., Domı́nguez, O., de Lera, T. L., García–Díaz, M., Bernad, A., & Blanco, L. (2001) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0754 · Cited by 62 · see citing works

Structure and Activity Associated with Multiple Forms ofSchizosaccharomyces pombe DNA Polymerase δ

Zuo, S., Bermudez, V. P., Zhang, G., Kelman, Z., & Hurwitz, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.5153 · Cited by 61 · see citing works

Closing the gaps among a web of DNA repair disorders

Michelson, R. J., & Weinert, T. A. (2000) · BioEssays · doi:10.1002/1521-1878(200011)22:11 · Cited by 61 · see citing works

DNA polymerase ɛ is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts

Shou, W.-G., Masuda, T., Takisawa, H., & Sugino, A. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.081088798 · Cited by 60 · see citing works

Replication Protein A as a “Fidelity Clamp” for DNA Polymerase α

Maga, G., Frouin, I., Spadari, S., & Hübscher, U. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009599200 · Cited by 56 · see citing works

Evidence That DNA Polymerase δ Isolated by Immunoaffinity Chromatography Exhibits High-Molecular Weight Characteristics and Is Associated with the KIAA0039 Protein and RPA

Mo, J., Liu, L., Leon, A., Mazloum, N. A., & Lee, M. (2000) · Biochemistry · doi:10.1021/bi0000871 · Cited by 55 · see citing works

Proliferating Cell Nuclear Antigen Promotes Misincorporation Catalyzed by Calf Thymus DNA Polymerase δ

Mozzherin, D. J., McConnell, M., Jasko, M. V., Krayevsky, A. A., Tan, C., Downey, K. M., & Fisher, P. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31711 · Cited by 53 · see citing works

Replication of UV-damaged DNA: new insights into links between DNA polymerases, mutagenesis and human disease

Lehmann, A. R. (2000) · Gene · doi:10.1016/s0378-1119(00)00250-x · Cited by 52 · see citing works

Subunit Interactions within the Saccharomyces cerevisiae DNA Polymerase ε (pol ε) Complex

Dua, R., Edwards, S., Levy, D. L., & Campbell, J. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002376200 · Cited by 47 · see citing works

A neutralizing antibody against human DNA polymerase epsilon inhibits cellular but not SV40 DNA replication

Pospiech, H. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.19.3799 · Cited by 47 · see citing works

A coordinated interplay: Proteins with multiple functions in DNA replication, DNA repair, cell cycle/ checkpoint control, and transcription

Stucki, M., Štagljar, I., Jónsson, Z. O., & Hübscher, U. (2000) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(00)65007-9 · Cited by 46 · see citing works

Acidic Residues Critical for the Activity and Biological Function of Yeast DNA Polymerase η

Kondratick, C. M., Washington, M. T., Prakash, S., & Prakash, L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2018-2025.2001 · Cited by 46 · see citing works

Information for Authors

(1997) · Biological Chemistry · doi:10.1515/bchm.1997.378.3-4.345 · Cited by 45 · see citing works

Dynamics of β and Proliferating Cell Nuclear Antigen Sliding Clamps in Traversing DNA Secondary Structure

Yao, N. Y., Hurwitz, J., & O’Donnell, M. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1421 · Cited by 39 · see citing works

The Hepatitis B Virus Transactivator Protein, HBx, Interacts with Single-stranded DNA (ssDNA)

Qadri, I., Ferrari, M. E., & Siddiqui, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15443 · Cited by 38 · see citing works

DNA synthesis control in yeast: An evolutionarily conserved mechanism for regulating DNA synthesis genes?

Merrill, G. F., Morgan, B. A., Lowndes, N. F., & Johnston, L. H. (1992) · BioEssays · doi:10.1002/bies.950141206 · Cited by 37 · see citing works

DNA Structure Requirements for the Escherichia coliγ Complex Clamp Loader and DNA Polymerase III Holoenzyme

Yao, N. Y., Leu, F. P., Anjelkovic, J., Turner, J., & O’Donnell, M. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11440 · Cited by 37 · see citing works

Mutagenic and Nonmutagenic Bypass of DNA Lesions byDrosophila DNA Polymerases dpolη and dpolι

Ishikawa, T., Uematsu, N., Mizukoshi, T., Iwai, S., Iwasaki, H., Masutani, C., Hanaoka, F., Ueda, R., Ohmori, H., & Todo, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009822200 · Cited by 37 · see citing works

Phosphorylation of the DNA Polymerase -Primase B Subunit Is Dependent on Its Association with the p180 Polypeptide

Ferrari, M., Lucchini, G., Plevani, P., & Foiani, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8661 · Cited by 35 · see citing works

A key role for replication factor C in DNA replication checkpoint function in fission yeast

Reynolds, N., Fantes, P. A., & MacNeill, S. A. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.2.462 · Cited by 35 · see citing works

A unified nomenclature for the subunits of eukaryotic DNA polymerase δ

MacNeill, S. A., Baldacci, G., Burgers, P., & Hübscher, U. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01709-6 · Cited by 31 · see citing works

Dual mode of interaction of DNA polymerase ϵ with proliferating cell nuclear antigen in primer binding and DNA synthesis

Maga, G., Jónsson, Z. O., Stucki, M., Spadari, S., & Hübscher, U. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2314 · Cited by 28 · see citing works

Characterization of the p125 Subunit of Human DNA Polymerase δ and Its Deletion Mutants

Wu, S., Zhang, P., Zeng, X. R., Zhang, S.-J., Mo, J., Li, B. Q., & Lee, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9561 · Cited by 24 · see citing works

Analysis of Fission Yeast Primase Defines the Checkpoint Responses to Aberrant S Phase Initiation

Tan, S., & Wang, T. S. ‐. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.7853-7866.2000 · Cited by 22 · see citing works

Localization by fluorescence in situ hybridization (FISH) of human mitochondrial polymerase γ (POLG) to human chromosome band 15q24→q26, and of mouse mitochondrial polymerase γ (Polg) to mouse chromosome band 7E, with confirmation by direct sequence analysis of bacterial artificial chromosomes (BACs)

Zullo, S. J., Butler, L., Zahorchak, R. J., Macville, M. V. E., Wilkes, C., & Merril, C. R. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000134672 · Cited by 20 · see citing works

The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon

Jokela, M. M. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.3.730 · Cited by 18 · see citing works

Clamping down on clamps and clamp loaders

Mossi, R., & Hübscher, U. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2540209.x · Cited by 9 · see citing works

Proliferating cell nuclear antigen (PCNA): a dancer with many partners

Maga, G., & Hübscher, U. (2003) · Journal of Cell Science · doi:10.1242/jcs.00653 · Cited by 1,093 · see citing works

DNA Replication Fidelity

Kunkel, T. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400006200 · Cited by 754 · see citing works

Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair

Gillet, L. C. J., & Schärer, O. D. (2006) · Chemical Reviews · doi:10.1021/cr040483f · Cited by 642 · see citing works

From Cascaded Catalytic Nucleic Acids to Enzyme–DNA Nanostructures: Controlling Reactivity, Sensing, Logic Operations, and Assembly of Complex Structures

Wang, F., Lü, C., & Willner, I. (2014) · Chemical Reviews · doi:10.1021/cr400354z · Cited by 647 · see citing works

DNA polymerases and cancer

Lange, S. S., Takata, K.-I., & Wood, R. D. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2998 · Cited by 615 · see citing works

Global Analysis of Arabidopsis Gene Expression Uncovers a Complex Array of Changes Impacting Pathogen Response and Cell Cycle during Geminivirus Infection

Ascencio‐Ibáñez, J. T., Sozzani, R., Lee, T.-J., Chu, T., Wolfinger, R. D., Cella, R., & Hanley-Bowdoin, L. K. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.121038 · Cited by 578 · see citing works

CELLULAR DNA REPLICASES: Components and Dynamics at the Replication Fork

Johnson, A. M., & O’Donnell, M. E. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073859 · Cited by 563 · see citing works

Photo- and Redox-Driven Artificial Molecular Motors

Baroncini, M., Silvi, S., & Credi, A. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00291 · Cited by 538 · see citing works

Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products

Neeley, W. L., & Essigmann, J. M. (2006) · Chemical Research in Toxicology · doi:10.1021/tx0600043 · Cited by 510 · see citing works

Eukaryotic Chromosome DNA Replication: Where, When, and How?

Masai, H., Matsumoto, S., You, Z., Yoshizawa-Sugata, N., & Oda, M. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.103205 · Cited by 494 · see citing works

Cadmium is a mutagen that acts by inhibiting mismatch repair

Jin, Y. H., Clark, A. B., Slebos, R. J. C., Al-Refai, H., Taylor, J. A., Kunkel, T. A., Resnick, M. A., & Gordenin, D. A. (2003) · Nature Genetics · doi:10.1038/ng1172 · Cited by 473 · see citing works

How telomeres are replicated

Gilson, É., & Géli, V. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2259 · Cited by 454 · see citing works

The Catalytic Mechanisms of Binuclear Metallohydrolases

Mitić, N., Smith, S. J., Neves, A., Guddat, L. W., Gahan, L. R., & Schenk, G. (2006) · Chemical Reviews · doi:10.1021/cr050318f · Cited by 440 · see citing works

DNA Polymerase γ, The Mitochondrial Replicase

Kaguni, L. S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161455 · Cited by 414 · see citing works

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

García-Gómez, S., Reyes, A., Martínez-Jiménez, M. I., Chocrón, E. S., Mouron, S. A., Terrados, G., Powell, C. A., SALIDO, E. C., Méndez, J., Holt, I. J., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.09.025 · Cited by 407 · see citing works

Why nature really chose phosphate

Kamerlin, S. C. L., Sharma, P. K., Prasad, R. B., & Warshel, A. (2013) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583512000157 · Cited by 403 · see citing works

Trading Places: How Do DNA Polymerases Switch during Translesion DNA Synthesis?

Friedberg, E. C., Lehmann, A. R., & Fuchs, R. P. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.032 · Cited by 376 · see citing works

Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

Guo, C., Fischhaber, P. L., Luk‐Paszyc, M. J., Masuda, Y., Zhou, J., Kamiya, K., Kisker, C., & Friedberg, E. C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg626 · Cited by 353 · see citing works

Dial 9–1–1 for DNA damage: the Rad9–Hus1–Rad1 (9–1–1) clamp complex

Parrilla-Castellar, E. R., Arlander, S. J. H., & Karnitz, L. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.032 · Cited by 342 · see citing works

Cell Cycle Progression in the Pericycle Is Not Sufficient for SOLITARY ROOT/IAA14-Mediated Lateral Root Initiation inArabidopsis thaliana

Vanneste, S., Rybel, B. D., Beemster, G. T. S., Ljung, K., Smet, I. D., Isterdael, G. V., Naudts, M., Iida, R., Gruissem, W., Tasaka, M., et al. (2005) · The Plant Cell · doi:10.1105/tpc.105.035493 · Cited by 343 · see citing works

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

Arias, E. E., & Walter, J. C. (2005) · Nature Cell Biology · doi:10.1038/ncb1346 · Cited by 314 · see citing works

Human DNA Polymerase η Promotes DNA Synthesis from Strand Invasion Intermediates of Homologous Recombination

McIlwraith, M. J., Vaisman, A., Liu, Y., Fanning, E., Woodgate, R., & West, S. C. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.001 · Cited by 304 · see citing works

Nuclear and mitochondrial DNA repair: similar pathways?

Larsen, N. B., Rasmussen, M., & Rasmussen, L. J. (2005) · Mitochondrion · doi:10.1016/j.mito.2005.02.002 · Cited by 289 · see citing works

Directed DNA Metallization

Burley, G. A., Gierlich, J., Mofid, M. R., Nir, H., Tal, S., Eichen, Y., & Carell, T. (2006) · Journal of the American Chemical Society · doi:10.1021/ja055517v · Cited by 285 · see citing works

The 3′–5′ exonucleases

Shevelev, I. V., & Hübscher, U. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm804 · Cited by 284 · see citing works

DNA Polymerases that Propagate the Eukaryotic DNA Replication Fork

Garg, P., & Burgers, P. (2005) · Critical reviews in biochemistry and molecular biology · doi:10.1080/10409230590935433 · Cited by 336 · see citing works

Suffering in silence: the tolerance of DNA damage

Friedberg, E. C. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1781 · Cited by 271 · see citing works

DNA polymerase lambda (Pol λ), a novel eukaryotic DNA polymerase with a potential role in meiosis 1 1Edited by M. Yaniv

García–Díaz, M., Domı́nguez, O., López-Fernández, L. A., de Lera, L. T., Sanı́ger, M. L., Ruiz, J. F., Párraga, M., Garcı́a-Ortiz, M. J., Kirchhoff, T., del Mazo, J., et al. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4005 · Cited by 264 · see citing works

Functions of DNA polymerases

Bebenek, K., & Kunkel, T. A. (2004) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(04)69005-x · Cited by 258 · see citing works

Translesion DNA polymerases in eukaryotes: what makes them tick?

Vaisman, A., & Woodgate, R. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1291576 · Cited by 247 · see citing works

Repair and tolerance of oxidative DNA damage in plants

Roldán‐Arjona, T., & Ariza, R. R. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.07.003 · Cited by 232 · see citing works

TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression

Ayala, Y. M., Misteli, T., & Baralle, F. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800546105 · Cited by 232 · see citing works

Human Mismatch Repair

Constantin, N., Dzantiev, L., Kadyrov, F. A., & Modrich, P. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509701200 · Cited by 225 · see citing works

The base excision repair: mechanisms and its relevance for cancer susceptibility

Fortini, P. (2003) · Biochimie · doi:10.1016/j.biochi.2003.11.003 · Cited by 224 · see citing works

8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

Maga, G., Villani, G., Crespan, E., Wimmer, U., Ferrari, E. S., Bertocci, B., & Hübscher, U. (2007) · Nature · doi:10.1038/nature05843 · Cited by 218 · see citing works

DNA polymerase θ (POLQ), double-strand break repair, and cancer

Wood, R. D., & Doublié, S. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.003 · Cited by 214 · see citing works

Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins

Méndez, J., & Stillman, B. (2003) · BioEssays · doi:10.1002/bies.10370 · Cited by 211 · see citing works

High‐efficiency bypass of DNA damage by human DNA polymerase Q

Seki, M., Masutani, C., Yang, L. W., Schuffert, A., Iwai, S., Bahar, İ., & Wood, R. D. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600424 · Cited by 209 · see citing works

The Transcriptional Profile of Mesenchymal Stem Cell Populations in Primary Osteoporosis Is Distinct and Shows Overexpression of Osteogenic Inhibitors

Benisch, P., Schilling, T., Klein‐Hitpaß, L., Frey, S. P., Seefried, L., Raaijmakers, N., Krug, M., Regensburger, M., Zeck, S., Schinke, T., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045142 · Cited by 208 · see citing works

Meta-analysis of new genome-wide association studies of colorectal cancer risk

Peters, U., Hutter, C. M., Hsu, L., Schumacher, F. R., Conti, D. V., Carlson, C. S., Edlund, C. K., Haile, R. W., Gallinger, S., Zanke, B. W., et al. (2011) · Human Genetics · doi:10.1007/s00439-011-1055-0 · Cited by 204 · see citing works

Claspin, a Chk1-Regulatory Protein, Monitors DNA Replication on Chromatin Independently of RPA, ATR, and Rad17

Lee, J., Kumagai, A., & Dunphy, W. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00045-5 · Cited by 199 · see citing works

Arginine Methylation Regulates DNA Polymerase β

El‐Andaloussi, N., Valovka, T., Toueille, M., Steinacher, R., Focke, F., Gehrig, P., Covic, M., Hassa, P. O., Schär, P., Hübscher, U., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.02.013 · Cited by 198 · see citing works

DNA replication and progression through S phase

Takeda, D. Y., & Dutta, A. (2005) · Oncogene · doi:10.1038/sj.onc.1208616 · Cited by 193 · see citing works

Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extractsPreprint

Arias, E. E., & Walter, J. C. (2004) · Genes & Development · doi:10.1101/gad.1255805 · Cited by 196 · see citing works

The replication clamp-loading machine at work in the three domains of life

Indiani, C., & O’Donnell, M. E. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2022 · Cited by 187 · see citing works

Error-Prone DNA Polymerases: When Making a Mistake is the Only Way to Get Ahead

Rattray, A. J., & Strathern, J. N. (2003) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.042203.132748 · Cited by 182 · see citing works

DNA replication fidelity and cancer

Preston, B. D., Albertson, T. M., & Herr, A. J. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.009 · Cited by 160 · see citing works

Structure of the processive human Pol δ holoenzyme

Lancey, C., Tehseen, M., Raducanu, V., Rashid, F., Merino, N., Ragan, T. J., Savva, C. G., Zaher, M. S., Shirbini, A., Blanco, F. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14898-6 · Cited by 163 · see citing works

Okazaki Fragment MetabolismPreprint

Balakrishnan, L., & Bambara, R. A. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a010173 · Cited by 151 · see citing works

Translesion Synthesis across Bulky N2-Alkyl Guanine DNA Adducts by Human DNA Polymerase κ

Choi, J., Angel, K. C., & Guengerich, F. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602246200 · Cited by 143 · see citing works

Human DNA Polymerase N (POLN) Is a Low Fidelity Enzyme Capable of Error-free Bypass of 5S-Thymine Glycol

Takata, K., Shimizu, T., Iwai, S., & Wood, R. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604317200 · Cited by 144 · see citing works

The Mouse Genomic Instability Mutation chaos1 Is an Allele of Polq That Exhibits Genetic Interaction with Atm

Shima, N., Munroe, R. J., & Schimenti, J. C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10381-10389.2004 · Cited by 144 · see citing works

Phylogenetic relationships within Echinococcus and Taenia tapeworms (Cestoda: Taeniidae): An inference from nuclear protein-coding genes

Knapp, J., Nakao, M., Yanagida, T., Okamoto, M., Saarma, U., Lavikainen, A., & Ito, A. (2011) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2011.07.022 · Cited by 142 · see citing works

Proteomic and genomic characterization of chromatin complexes at a boundary

Tackett, A. J., Dilworth, D. J., Davey, M. J., O’Donnell, M. E., Aitchison, J. D., Rout, M. P., & Chait, B. T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502104 · Cited by 142 · see citing works

INCURVATA2 Encodes the Catalytic Subunit of DNA Polymerase α and Interacts with Genes Involved in Chromatin-Mediated Cellular Memory in Arabidopsis thaliana

Barrero, J. M., González‐Bayón, R., del Pozo, J. C., Ponce, M. R., & Micol, J. L. (2007) · The Plant Cell · doi:10.1105/tpc.107.054130 · Cited by 142 · see citing works

DNA polymerase θ is preferentially expressed in lymphoid tissues and upregulated in human cancers

Kawamura, K., Bahar, R., Seimiya, M., Chiyo, M., Wada, A., Okada, S., Hatano, M., Tokuhisa, T., Kimura, H., Watanabe, S., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.11666 · Cited by 140 · see citing works

DNA polymerase delta in dna replication and genome maintenance

Prindle, M. J., & Loeb, L. A. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21745 · Cited by 133 · see citing works

An Iron-Sulfur Cluster in the C-terminal Domain of the p58 Subunit of Human DNA Primase

Weiner, B. E., Huang, H., Dattilo, B. M., Nilges, M. J., Fanning, E., & Chazin, W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705826200 · Cited by 136 · see citing works

Molecular diagnosis of Alpers syndrome

Nguyen, K. V., Sharief, F. S., Chan, S. S. L., Copeland, W. C., & Naviaux, R. K. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2005.12.026 · Cited by 136 · see citing works

Multiple Mitochondrial DNA Polymerases in Trypanosoma brucei

Klingbeil, M. M., Motyka, S. A., & Englund, P. T. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00571-3 · Cited by 127 · see citing works

New roles for the major human 3′-5′ exonuclease TREX1 in human disease

Kavanagh, D., Spitzer, D., Kothari, P. H., Shaikh, A., Liszewski, M. K., Richards, A., & Atkinson, J. P. (2008) · Cell Cycle · doi:10.4161/cc.7.12.6162 · Cited by 132 · see citing works

Saccharomyces cerevisiae DNA Polymerase δ

Fortune, J. M., Pavlov, Y. I., Welch, C. M., Johansson, E., Burgers, P., & Kunkel, T. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505236200 · Cited by 128 · see citing works

Loss of DNA Polymerase ζ Causes Chromosomal Instability in Mammalian Cells

Wittschieben, J. P., Reshmi, S. C., Gollin, S. M., & Wood, R. D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2982 · Cited by 127 · see citing works

A highly integrated DNA nanomachine operating in living cells powered by an endogenous stimulus

Ma, P., Liang, C., Zhang, H., Yin, B., & Ye, B. (2018) · Chemical Science · doi:10.1039/c8sc00049b · Cited by 125 · see citing works

Roles of DNA Polymerases in Replication, Repair, and Recombination in Eukaryotes

Pavlov, Y. I., Shcherbakova, P. V., & Rogozin, I. B. (2006) · International Review of Cytology · doi:10.1016/s0074-7696(06)55002-8 · Cited by 123 · see citing works

The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase   and increases its DNA substrate utilisation efficiency: implications for DNA repair

Toueille, M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh652 · Cited by 122 · see citing works

Extraordinary genome stability in the ciliate Paramecium tetraurelia

Sung, W., Tucker, A. E., Doak, T. G., Choi, E., Thomas, W. K., & Lynch, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210663109 · Cited by 119 · see citing works

Structure and function of the telomeric CST complex

Rice, C., & Skordalakes, E. (2016) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2016.04.002 · Cited by 109 · see citing works

Biochemical, Structural, and Physiological Characterization of Terminal Deoxynucleotidyl Transferase

Fowler, J. D., & Suo, Z. (2006) · Chemical Reviews · doi:10.1021/cr040445w · Cited by 119 · see citing works

Probing the active site tightness of DNA polymerase in subangstrom increments

Kim, T. W., Delaney, J. C., Essigmann, J. M., & Kool, E. T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505113102 · Cited by 116 · see citing works

Multiple Functions of DNA Polymerases

García–Díaz, M., & Bębenek, K. (2007) · Critical Reviews in Plant Sciences · doi:10.1080/07352680701252817 · Cited by 116 · see citing works

The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation

Zan, H., Shima, N., Xu, Z., Al-Qahtani, A. A., Evinger, A. J., Zhong, Y., Schimenti, J. C., & Casali, P. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600833 · Cited by 115 · see citing works

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks

Yan, S., & Michael, W. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200810185 · Cited by 107 · see citing works

On the Interpretation of the Observed Linear Free Energy Relationship in Phosphate Hydrolysis: A Thorough Computational Study of Phosphate Diester Hydrolysis in Solution

Rosta, E., Kamerlin, S. C. L., & Warshel, A. (2008) · Biochemistry · doi:10.1021/bi702106m · Cited by 112 · see citing works

Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors

Tahirov, T. H., Makarova, K. S., Rogozin, I. B., Pavlov, Y. I., & Koonin, E. V. (2009) · Biology Direct · doi:10.1186/1745-6150-4-11 · Cited by 110 · see citing works

DNA polymerase θ contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

Masuda, K., Ouchida, R., Takeuchi, A., Saito, T., Koseki, H., Kawamura, K., Tagawa, M., Tokuhisa, T., Azuma, T., & Wang, J. O. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505636102 · Cited by 110 · see citing works

Structure of a bifunctional DNA primase-polymerase

Lipps, G., Weinzierl, A. O., von Scheven, G., Buchen, C., & Cramer, P. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb723 · Cited by 109 · see citing works

Formation of Bimetallic Ag–Au Nanowires by Metallization of Artificial DNA Duplexes

Fischler, M., Simon, U., Nir, H., Eichen, Y., Burley, G. A., Gierlich, J., Gramlich, P. M. E., & Carell, T. (2007) · Small · doi:10.1002/smll.200600534 · Cited by 109 · see citing works

DNA Polymerase λ Protects Mouse Fibroblasts against Oxidative DNA Damage and Is Recruited to Sites of DNA Damage/Repair

Braithwaite, E. K., Kedar, P. S., Lan, L., Polosina, Y. Y., Asagoshi, K., Poltoratsky, V. P., Horton, J. K., Miller, H., Teebor, G. W., Yasui, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500256200 · Cited by 109 · see citing works

PCNA acts as a stationary loading platform for transiently interacting Okazaki fragment maturation proteins

Sporbert, A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki665 · Cited by 108 · see citing works

Continued primer synthesis at stalled replication forks contributes to checkpoint activation

Van, C., Yan, S., Michael, W. M., Waga, S., & Cimprich, K. A. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200909105 · Cited by 100 · see citing works

Human DNA Polymerase κ Bypasses and Extends beyond Thymine Glycols during Translesion Synthesis in Vitro, Preferentially Incorporating Correct Nucleotides

Fischhaber, P. L., Gerlach, V. L., Feaver, W. J., Hatahet, Z., Wallace, S. S., & Friedberg, E. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206027200 · Cited by 106 · see citing works

Regulation of cell cycle checkpoints by polo-like kinases

Xie, S., Xie, B., Lee, M. Y., & Dai, W. H. (2005) · Oncogene · doi:10.1038/sj.onc.1208218 · Cited by 106 · see citing works

The Protein Components and Mechanism of Eukaryotic Okazaki Fragment Maturation

Kao, H.-I., & Bambara, R. A. (2003) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230390259382 · Cited by 100 · see citing works

Human DNA Polymerase λ Functionally and Physically Interacts with Proliferating Cell Nuclear Antigen in Normal and Translesion DNA Synthesis

Maga, G., Villani, G., Ramadan, K., Shevelev, I., Gac, N. T. L., Blanco, L., Blanca, G., Spadari, S., & Hübscher, U. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206889200 · Cited by 103 · see citing works

DNA Repair in Mammalian Cells

Kunz, C., Saito, Y., & Schär, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8739-9 · Cited by 101 · see citing works

DNA repair nucleases

Marti, T. M., & Fleck, O. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3223-4 · Cited by 100 · see citing works

A novel type of replicative enzyme harbouring ATPase, primase and DNA polymerase activity

Lipps, G., Röther, S., Hart, C., & Krauss, G. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg246 · Cited by 102 · see citing works

Identification of a Novel Protein, PDIP38, That Interacts with the p50 Subunit of DNA Polymerase δ and Proliferating Cell Nuclear Antigen

Liu, L., Rodriguez-Belmonte, E. M., Mazloum, N. A., Xie, B., & Lee, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208694200 · Cited by 102 · see citing works

Mutation at the Polymerase Active Site of Mouse DNA Polymerase δ Increases Genomic Instability and Accelerates Tumorigenesis

Venkatesan, R. N., Treuting, P. M., Fuller, E. D., Goldsby, R. E., Norwood, T. H., Gooley, T. A., Ladiges, W., Preston, B. D., & Loeb, L. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00002-07 · Cited by 102 · see citing works

Pif1 Helicase Directs Eukaryotic Okazaki Fragments toward the Two-nuclease Cleavage Pathway for Primer Removal

Rossi, M. L., Pike, J. E., Wang, W., Burgers, P., Campbell, J. L., & Bambara, R. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804550200 · Cited by 101 · see citing works

Mechanism for priming DNA synthesis by yeast DNA Polymerase α

Perera, R. L., Torella, R., Klinge, S., Kilkenny, M. L., Maman, J. D., & Pellegrini, L. (2013) · eLife · doi:10.7554/elife.00482 · Cited by 101 · see citing works

DNA polymerase POLQ and cellular defense against DNA damage

Yousefzadeh, M. J., & Wood, R. D. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.10.004 · Cited by 102 · see citing works

The transcriptional response of Arabidopsis to genotoxic stress – a high‐density colony array study (HDCA)

Chen, I.-P., Hähnel, U., Altschmied, L., Schubert, I. A., & Puchta, H. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01847.x · Cited by 100 · see citing works

Polymerase ε1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature (“FILS syndrome”)

Schmid, J. P., Lemoine, R., Nehme, N. T., Cormier‐Daire, V., Revy, P., Debeurme, F., Debré, M., Nitschké, P., Bôle‐Feysot, C., Legeai‐Mallet, L., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121303 · Cited by 99 · see citing works

Ddb1 controls genome stability and meiosis in fission yeastPreprint

Holmberg, C., Fleck, O., Hansen, H. A., Liu, C., Slaaby, R., Carr, A. M., & Nielsen, O. (2005) · Genes & Development · doi:10.1101/gad.329905 · Cited by 100 · see citing works

Polymerase η mRNA Expression Predicts Survival of Non–Small Cell Lung Cancer Patients Treated with Platinum-Based Chemotherapy

Ceppi, P., Novello, S., Cambieri, A., Longo, M., Monica, V., Iacono, M. L., Levra, M. G., Saviozzi, S., Volante, M., Papotti, M. G., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1227 · Cited by 98 · see citing works

The Hyperthermophilic Euryarchaeota Pyrococcus abyssi Likely Requires the Two DNA Polymerases D and B for DNA Replication

Henneke, G., Flament, D., Hübscher, U., Quérellou, J., & Raffin, J. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.04.042 · Cited by 95 · see citing works

Replication through an abasic DNA lesion: structural basis for adenine selectivity

Obeid, S., Blatter, N., Kranaster, R., Schnur, A., Diederichs, K., Welte, W., & Marx, A. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.64 · Cited by 91 · see citing works

The RAD6 Pathway: Control of DNA Damage Bypass and Mutagenesis by Ubiquitin and SUMO

Ulrich, H. D. (2005) · ChemBioChem · doi:10.1002/cbic.200500139 · Cited by 93 · see citing works

An Evolutionary Perspective: DNA Polymerases Have a Very Conserved

Maga, G., Spadari, S., & Abbiategrasso, V. (2014)

Eukaryotic DNA polymerases, a growing family

Hübscher, U., Nasheuer, H., & Syväoja, J. E. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01523-6 · Cited by 220 · see citing works

Dna polymerases and their role in genomic stability

Eckert, K. A., & Sweasy, J. B. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21746 · Cited by 1 · see citing works

Plant DNA Polymerases

Garcia, J. A. P., Veylder, L. D., & Raynaud, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194814 · Cited by 30 · see citing works

The critical roles of DNA polymerases in genome stability and related human diseases

You, Z. (2014) · Shengming kexue