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Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade
Open accessAbstract
Rac and Cdc42 regulate a variety of responses in mammalian cells including formation of lamellipodia and filopodia, activation of the JNK MAP kinase cascade, and induction of G1 cell cycle progression. Rac is also one of the downstream targets required for Ras-induced malignant transformation. Rac and Cdc42 containing a Y40C effector site substitution no longer intact with the Ser/Thr kinase p65PAK and are unable to activate the JNK MAP kinase pathway. However, they still induce cytoskeletal changes and G1 cell cycle progression. Rac containing an F37A effector site substitution, on the other hand, no longer interacts with the Ser/Thr kinase p160ROCK and is unable to induce lamellipodia or G1 progression. We conclude that Rac and Cdc42 control MAP kinase pathways and actin cytoskeleton organization independently through distinct downstream targets.
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Citations
Cited by
Giancotti, F. G., & Ruoslahti, E. (1999) · Science · doi:10.1126/science.285.5430.1028 · Cited by 3,869
Rho GTPases and their effector proteins
BISHOP, A. L., & HALL, A. (2000) · Biochemical Journal · doi:10.1042/bj3480241 · Cited by 2,575
Self-citationIdentification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
Caron, E., & Hall, A. (1998) · Science · doi:10.1126/science.282.5394.1717 · Cited by 1,019
Self-citationRequirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
Cox, D., Chang, P., Zhang, Q., Reddy, P. G., Bokoch, G. M., & Greenberg, S. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1487 · Cited by 436
An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways.
Inoue, T., Heo, W. D., Grimley, J. S., Wandless, T. J., & Meyer, T. (2005) · Nature Methods · doi:10.1038/nmeth763 · Cited by 424
Metadata
- Authors
- Lamarche, N., Tapon, N., Stowers, L., Burbelo, P. D., Aspenström, P., Bridges, T., Chant, J., & Hall, A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 87
- Issue
- 3
- Pages
- 519-529
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2002410732
- Cited by
- 572
- References
- 0
- FWCI
- 22.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81371-9
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- Lamarche, N., Tapon, N., Stowers, L., Burbelo, P. D., Aspenström, P., Bridges, T., Chant, J., & Hall, A. (1996). Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade. Cell. https://doi.org/10.1016/s0092-8674(00)81371-9
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