The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4
Open accessAbstract
Several members of the chemokine receptor family have been shown to function in association with CD4 to permit HIV-1 entry and infection. However, the mechanism by which these molecules serve as CD4-associated cofactors is unclear. In the present report, we show that one member of this family, termed Fusin/ CXCR4, is able to function as an alternative receptor for some isolates of HIV-2 in the absence of CD4. This conclusion is supported by the finding that (1) CD4-independent infection by these viruses is inhibited by an anti-Fusin monoclonal antibody, (2) Fusin expression renders human and nonhuman CD4-negative cell lines sensitive to HIV-2-induced syncytium induction and/or infection, and (3) Fusin is selectively down-regulated from the cell surface following HIV-2 infection. The finding that one chemokine receptor can function as a primary viral receptor strongly suggests that the HIV envelope glycoprotein contains a binding site for these proteins and that differences in the affinity and/or the availability of this site can extend the host range of these viruses to include a number of CD4-negative cell types.
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Cites
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Self-citationHIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
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Cited by
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
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Self-citationThe HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes
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Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist
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Metadata
- Authors
- Endres, M. J., Clapham, P. R., Marsh, M., Ahuja, M., Turner, J. D., McKnight, A., Thomas, J. F., Stoebenau-Haggarty, B., Choe, S., Vance, P. J., Wells, T. N. C., Power, C. A., Sutterwala, S. S., Doms, R. W., Landau, N. R., & Hoxie, J. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 87
- Issue
- 4
- Pages
- 745-756
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2075416959
- Cited by
- 655
- References
- 38
- FWCI
- 26.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81393-8
- The paper
- Endres, M. J., Clapham, P. R., Marsh, M., Ahuja, M., Turner, J. D., McKnight, A., Thomas, J. F., Stoebenau-Haggarty, B., Choe, S., Vance, P. J., Wells, T. N. C., Power, C. A., Sutterwala, S. S., Doms, R. W., Landau, N. R., & Hoxie, J. A. (1996). CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4. Cell. https://doi.org/10.1016/s0092-8674(00)81393-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
