Cited by 1,521Cancer-related Molecular PathwaysHeat shock proteins researchPI3K/AKT/mTOR signaling in cancer

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53

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Pomerantz, Jason, Schreiber-Agus, Nicole, Liégeois, Nanette J, Silverman, Adam, Alland, Leila, Chin, Lynda, Potes, Jason, Chen, Ken, Orlow, Irene, Lee, Han-Woong, Cordon-Cardo, Carlos, DePinho, Ronald A·1998·Cell

DOI 10.1016/s0092-8674(00)81400-2

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Abstract

The INK4a gene encodes two distinct growth inhibitors--the cyclin-dependent kinase inhibitor p16Ink4a, which is a component of the Rb pathway, and the tumor suppressor p19Arf, which has been functionally linked to p53. Here we show that p19Arf potently suppresses oncogenic transformation in primary cells and that this function is abrogated when p53 is neutralized by viral oncoproteins and dominant-negative mutants but not by the p53 antagonist MDM2. This finding, coupled with the observations that p19Arf and MDM2 physically interact and that p19Rrf blocks MDM2-induced p53 degradation and transactivational silencing, suggests that p19Arf functions mechanistically to prevent MDM2's neutralization of p53. Together, our findings ascribe INK4a's potent tumor suppressor activity to the cooperative actions of its two protein products and their relation to the two central growth control pathways, Rb and p53.

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WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells
Gorman, C., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,674
Cancer Cell Cycles
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
The p53 tumour suppressor gene
Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312

Show all 72 references

Research works printed but not linked: 6

Brenner, 1996, Preferential loss of expression of p16INK4a rather than p19ARF in breast cancer, Clin. Cancer Res., 2, 1993
Elledge, 1996, A question of balance, Trends Biochem. Sci., 6, 388
Kinoshita, 1996, Altered p16INK4 and retinoblastoma protein status in non-small cell lung cancer, Cancer Res., 56, 5557
Quelle, 1995, Cloning and characterization of murine p16INK4a and p15INK4b genes, Oncogene, 11, 635
Schreiber-Agus, 1994, Evolutionary relationships and functional conservation among vertebrate Max-associated proteins, Oncogene, 9, 3167
Schreiber-Agus, 1997, An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3, Cell, 80, 777, 10.1016/0092-8674(95)90356-9 · DOI

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Cherubini, G., Petouchoff, T., Grossi, M., Piersanti, S., Cundari, E., & Saggio, I. (2006) · Cell Cycle · doi:10.4161/cc.5.19.3263 · Cited by 50
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Schaefer, T., Steiner, R., & Lengerke, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144902 · Cited by 51
Induction of cell death by adenoviruses
Braithwaite, A. W., & Russell, I. A. (2001) · APOPTOSIS · doi:10.1023/a:1011338119712 · Cited by 48
Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia.
Omura‐Minamisawa, M., Diccianni, M. B., Batova, A., Chang, R. C., Bridgeman, L. J., Yu, A. L.-T., Pullen, J., Bowman, W. P., & Yu, A. L.-T. (2000) · PubMed · Cited by 48
TP53-dependent chromosome instability is associated with transient reductions in telomere length in immortal telomerase-positive cell lines
Schwartz, J. L., Jordan, R. T., Liber, H. L., Murnane, J. P., & Evans, H. H. (2001) · Genes Chromosomes and Cancer · doi:10.1002/1098-2264(2000)9999:9999 · Cited by 27
Molecular alterations at chromosome 9p21 in melanocytic naevi and melanoma
Sini, M. C., Manca, A., Cossu, A., Budroni, M., Botti, G., Ascierto, P. A., Cremona, F., Muggiano, A., D’Atri, S., Casula, M., et al. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08310.x · Cited by 47
Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignancies
Katano, H., Sato, Y., & Sata, T. (2001) · Cancer · doi:10.1002/1097-0142(20011215)92:12 · Cited by 81
Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma
Fukai, K., Yokosuka, O., Imazeki, F., Tada, M., Mikata, R., Miyazaki, M., Ochiai, T., & Saisho, H. (2005) · Liver International · doi:10.1111/j.1478-3231.2005.01162.x · Cited by 47
Intranuclear compartmentalization of cyclin E during the cell cycle: disruption of the nucleoplasm-nucleolar shuttling of cyclin E in bladder cancer.
Juan, G., & Cordon‐Cardo, C. (2001) · PubMed · Cited by 47
Self-citation
Methylation, expression, and mutation analysis of the cell cycle control genes in human brain tumors
Yin, D., Xie, D., Hofmann, W., Miller, C. W., Black, K. L., & Koeffler, H. P. (2002) · Oncogene · doi:10.1038/sj.onc.1206031 · Cited by 47
Inactivation of the INK4a/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines
Caca, K., Feisthammel, J., Klee, K., Tannapfel, A., Witzigmann, H., Wittekind, C., Mössner, J., & Berr, F. (2001) · International Journal of Cancer · doi:10.1002/ijc.1639 · Cited by 47
HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F–p73 pathway
Finzer, P., Krueger, A., Stöhr, M., Brenner, D., Soto, U., Kuntzen, C., Krammer, P. H., & Rösl, F. (2004) · Oncogene · doi:10.1038/sj.onc.1207620 · Cited by 47
The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Dannenberg, J.-H., & te Riele, H. P. J. (2006) · Results and Problems in Cell Differentiation · doi:10.1007/400_002 · Cited by 47
Melanoma Susceptibility Genes and Risk Assessment
Marzuka-Alcalá, A., Gabree, M., & Tsao, H. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-727-3_20 · Cited by 47
Cell cycle regulation in H2O2-induced premature senescence of human diploid fibroblasts and regulatory control exerted by the papilloma virusE6 and E7 proteins
Frippiat, C., Chen, Q. M., Remacle, J., & Toussaint, O. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00167-4 · Cited by 46
TGFα transgenic mice
Greten, F. R., Wagner, M., Weber, C. K., Zechner, U., Adler, G., & Schmid, R. M. (2001) · Pancreatology · doi:10.1159/000055835 · Cited by 46
Analysis of the molecular species generated by mdm2 gene amplification in liposarcomas
Tamborini, E., Torre, G. D., Lavarino, C. E., Azzarelli, A., Carpinelli, P., Pierotti, M. A., & Pilotti, S. (2001) · International Journal of Cancer · doi:10.1002/ijc.1271 · Cited by 46
Impact of E27X, a novel CDKN2A germ line mutation, on p16 and p14ARF expression in Italian melanoma families displaying pancreatic cancer and neuroblastoma
Ghiorzo, P., Gargiulo, S., Pastorino, L., Nasti, S., Cusano, R., Bruno, W., Gliori, S., Sertoli, M. R., Burroni, A. G., Savarino, V., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl199 · Cited by 46
Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course.
Watanabe, T., Katayama, Y., Yoshino, A., Komine, C., & Yokoyama, T. (2003) · PubMed · Cited by 46
Loss of heterozygosity at chromosome 9p21 is a frequent finding in enteropathy‐type T‐cell lymphoma
Obermann, E. C., Diss, T. C., Hamoudi, R., Munson, P., Wilkins, B., Camozzi, M. L. P., Isaacson, P. G., Du, M., & Doǧan, A. (2004) · The Journal of Pathology · doi:10.1002/path.1506 · Cited by 46
Negative control elements of the cell cycle in human tumors
Adams, P. D., & Kaelin, W. G. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80123-3 · Cited by 46
ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets
Carlos, A. R., Escandell, J. M., Kotsantis, P., Suwaki, N., Bouwman, P., Badie, S., Folio, C., Benitez, J. J., Goméz-López, G., Pisano, D. G., et al. (2013) · Nature Communications · doi:10.1038/ncomms3697 · Cited by 47
Comparison of p16INK4a expression with p53 alterations in head and neck cancer by tissue microarray analysis
Karsai, S., Abel, U. R., Roesch‐Ely, M., Affolter, A., Hofele, C., Joos, S., Plinkert, P., & Bosch, F. (2006) · The Journal of Pathology · doi:10.1002/path.2100 · Cited by 45
Stepwise Neoplastic Transformation of a Telomerase Immortalized Fibroblast Cell Line
Zongaro, S., de Stanchina, E., Colombo, T., D’Incalci, M., Giulotto, E., & Mondello, C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1140 · Cited by 45

Authors: Pomerantz, J., Schreiber-Agus, N., Liégeois, N. J., Silverman, A., Alland, L., Chin, L., Potes, J., Chen, K., Orlow, I., Lee, H.-W., Cordon-Cardo, C., & DePinho, R. A.
Affiliations: Albert Einstein College of Medicine (US)
Memorial Sloan Kettering Cancer Center (US)
Corresponding author: DePinho, Ronald A
ORCID: Pomerantz, Jason
Liégeois, Nanette J
Chen, Ken
Orlow, Irene
Lee, Han-Woong
DePinho, Ronald A
Venue: Cell
Publisher: Elsevier BV
Published: 1998-03
Volume: 92
Issue: 6
Pages: 713-723
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)81400-2
OpenAlex: W2039463309
Cited by: 1,521
References: 72
Citations by year: 2026: 4 · 2025: 10 · 2024: 6 · 2023: 23 · 2022: 19 · 2021: 23 · 2020: 19 · 2019: 16 · 2018: 12 · 2017: 24 · 2016: 27 · 2015: 32 · 2014: 44 · 2013: 44 · 2012: 47
FWCI: 64.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5617 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 47179, CA 47538, CADK97650, P01CA047179)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: p19ARF, INK4A, MDM2, p53, tumor suppression, protein-protein interaction, p53 degradation, p53 transactivation, oncogenic transformation, Rb pathway, viral oncoproteins, dominant-negative mutant
MeSH terms: Animals, Biotin, Cell Line, Deoxyuracil Nucleotides, Lens, Crystalline, Neoplasm Proteins, Nuclear Proteins, Osteoblasts, Proteins, Proto-Oncogene Proteins, Staining and Labeling, Transformation, Genetic, Tumor Suppressor Protein p53, Retinoblastoma Protein, Apoptosis, Genes, p16, Tumor Suppressor Protein p14ARF, Mice, Proto-Oncogene Proteins c-mdm2, DNA Fragmentation

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53

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