Cited by 1,521Cancer-related Molecular PathwaysHeat shock proteins researchPI3K/AKT/mTOR signaling in cancer

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53

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Pomerantz, Jason, Schreiber-Agus, Nicole, Liégeois, Nanette J, Silverman, Adam, Alland, Leila, Chin, Lynda, Potes, Jason, Chen, Ken, Orlow, Irene, Lee, Han-Woong, Cordon-Cardo, Carlos, DePinho, Ronald A·1998·Cell

DOI 10.1016/s0092-8674(00)81400-2

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Abstract

The INK4a gene encodes two distinct growth inhibitors--the cyclin-dependent kinase inhibitor p16Ink4a, which is a component of the Rb pathway, and the tumor suppressor p19Arf, which has been functionally linked to p53. Here we show that p19Arf potently suppresses oncogenic transformation in primary cells and that this function is abrogated when p53 is neutralized by viral oncoproteins and dominant-negative mutants but not by the p53 antagonist MDM2. This finding, coupled with the observations that p19Arf and MDM2 physically interact and that p19Rrf blocks MDM2-induced p53 degradation and transactivational silencing, suggests that p19Arf functions mechanistically to prevent MDM2's neutralization of p53. Together, our findings ascribe INK4a's potent tumor suppressor activity to the cooperative actions of its two protein products and their relation to the two central growth control pathways, Rb and p53.

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WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells
Gorman, C., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,674
Cancer Cell Cycles
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
The p53 tumour suppressor gene
Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312

Show all 72 references

Research works printed but not linked: 6

Brenner, 1996, Preferential loss of expression of p16INK4a rather than p19ARF in breast cancer, Clin. Cancer Res., 2, 1993
Elledge, 1996, A question of balance, Trends Biochem. Sci., 6, 388
Kinoshita, 1996, Altered p16INK4 and retinoblastoma protein status in non-small cell lung cancer, Cancer Res., 56, 5557
Quelle, 1995, Cloning and characterization of murine p16INK4a and p15INK4b genes, Oncogene, 11, 635
Schreiber-Agus, 1994, Evolutionary relationships and functional conservation among vertebrate Max-associated proteins, Oncogene, 9, 3167
Schreiber-Agus, 1997, An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3, Cell, 80, 777, 10.1016/0092-8674(95)90356-9 · DOI

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Meek, D. W. (1998) · International Journal of Radiation Biology · doi:10.1080/095530098141005 · Cited by 35
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Molecular pathogenesis of adult brain tumors and the role of stem cells.
Sauvageot, C., Kesari, S., & Stiles, C. (2007) · Neurologic clinics · doi:10.1016/j.ncl.2007.07.014 · Cited by 36
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Giuliano, S., Ohanna, M., Ballotti, R., & Bertolotto, C. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00820.x · Cited by 39
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Araki, T., Shinoda, S., Schindler, C. K., Quan‐Lan, J., Meller, R., Taki, W., Simon, R. P., & Henshall, D. C. (2004) · Hippocampus · doi:10.1002/hipo.10184 · Cited by 34
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O’Shea, C. C., & Fried, M. (2005) · Cell Cycle · doi:10.4161/cc.4.3.1555 · Cited by 29
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Britigan, E. M. C., Wan, J., Zasadil, L. M., Ryan, S. D., & Weaver, B. A. A. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-05-0966 · Cited by 30
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Yamanaka, R., & Saya, H. (2009) · Annals of Neurology · doi:10.1002/ana.21793 · Cited by 29
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Ko, E., Kim, Y., Kim, S.-J., Joh, J., Song, S., Park, C.-K., Park, J., & Kim, D.-H. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0236 · Cited by 29
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Šmardová, J., Šmarda, J., & Koptíková, J. (2005) · Differentiation · doi:10.1111/j.1432-0436.2005.00028.x · Cited by 29
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Zanola, A., Rossi, S., Faggi, F., Monti, E., & Fanzani, A. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01518.x · Cited by 28
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Hesse, R. G., Kouklis, G. K., Ahituv, N., & Pomerantz, J. H. (2015) · eLife · doi:10.7554/elife.07702 · Cited by 28
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Naemura, M., Tsunoda, T., Inoue, Y., Okamoto, H., Shirasawa, S., & Kotake, Y. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2618-5 · Cited by 28
Genomic Imbalances in Drug-Resistant T-Cell Acute Lymphoblastic CEM Leukemia Cell Lines
Efferth, T., Verdorfer, I., Miyachi, H., Sauerbrey, A., Drexler, H. G., Chitambar, C. R., Haber, M., & Gebhart, E. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0530 · Cited by 28
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Abdul-Nabi, A. M., Yassin, E. R., Varghese, N., Deshmukh, H., & Yaseen, N. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012464 · Cited by 28
Decreased survival of C/EBPβ-deficient keratinocytes is due to aberrant regulation of p53 levels and function
Yoon, K., Zhu, S., Ewing, S. J., & Smart, R. C. (2006) · Oncogene · doi:10.1038/sj.onc.1209797 · Cited by 28
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Wong, A. K., & Chin, L. (2000) · Cancer and Metastasis Reviews · doi:10.1023/a:1026537423753 · Cited by 28
Self-citation
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Maemondo, M., Saijo, Y., Narumi, K., Kikuchi, T., Usui, K., Tazawa, R., Matsumoto, K., Nakamura, T., Sasaki, K., Takahashi, M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2549 · Cited by 28

Authors: Pomerantz, J., Schreiber-Agus, N., Liégeois, N. J., Silverman, A., Alland, L., Chin, L., Potes, J., Chen, K., Orlow, I., Lee, H.-W., Cordon-Cardo, C., & DePinho, R. A.
Affiliations: Albert Einstein College of Medicine (US)
Memorial Sloan Kettering Cancer Center (US)
Corresponding author: DePinho, Ronald A
ORCID: Pomerantz, Jason
Liégeois, Nanette J
Chen, Ken
Orlow, Irene
Lee, Han-Woong
DePinho, Ronald A
Venue: Cell
Publisher: Elsevier BV
Published: 1998-03
Volume: 92
Issue: 6
Pages: 713-723
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)81400-2
OpenAlex: W2039463309
Cited by: 1,521
References: 72
Citations by year: 2026: 4 · 2025: 10 · 2024: 6 · 2023: 23 · 2022: 19 · 2021: 23 · 2020: 19 · 2019: 16 · 2018: 12 · 2017: 24 · 2016: 27 · 2015: 32 · 2014: 44 · 2013: 44 · 2012: 47
FWCI: 64.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5617 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 47179, CA 47538, CADK97650, P01CA047179)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: p19ARF, INK4A, MDM2, p53, tumor suppression, protein-protein interaction, p53 degradation, p53 transactivation, oncogenic transformation, Rb pathway, viral oncoproteins, dominant-negative mutant
MeSH terms: Animals, Biotin, Cell Line, Deoxyuracil Nucleotides, Lens, Crystalline, Neoplasm Proteins, Nuclear Proteins, Osteoblasts, Proteins, Proto-Oncogene Proteins, Staining and Labeling, Transformation, Genetic, Tumor Suppressor Protein p53, Retinoblastoma Protein, Apoptosis, Genes, p16, Tumor Suppressor Protein p14ARF, Mice, Proto-Oncogene Proteins c-mdm2, DNA Fragmentation

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53

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