The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain
Open accessAbstract
The generation of pacemaker activity in heart and brain is mediated by hyperpolarization-activated cation channels that are directly regulated by cyclic nucleotides. We previously cloned a novel member of the voltage-gated K channel family from mouse brain (mBCNG-1) that contained a carboxy-terminal cyclic nucleotide-binding domain (Santoro et al., 1997) and hence proposed it to be a candidate gene for pacemaker channels. Heterologous expression of mBCNG-1 demonstrates that it does indeed code for a channel with properties indistinguishable from pacemaker channels in brain and similar to those in heart. Three additional mouse genes and two human genes closely related to mBCNG-1 display unique patterns of mRNA expression in different tissues, including brain and heart, demonstrating that these channels constitute a widely expressed gene family.
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Cites
Sleep and arousal: thalamocortical mechanisms
McCormick, D. A., & Bal, T. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.185 · Cited by 1,267
Cited by
Magee, J. C. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07613.1998 · Cited by 981
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889
Santoro, B., Chen, S., Lüthi, A., Pavlidis, P., Shumyatsky, G. P., Tibbs, G. R., & Siegelbaum, S. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05264.2000 · Cited by 600
Self-citationChen, S., Wang, J., & Siegelbaum, S. A. (2001) · The Journal of General Physiology · doi:10.1085/jgp.117.5.491 · Cited by 416
Self-citationShi, W., Wymore, R., Yu, H., Wu, J., Wymore, R. T., Pan, Z., Robinson, R. B., Dixon, J. E., McKinnon, D., & Cohen, I. S. (1999) · Circulation Research · doi:10.1161/01.res.85.1.e1 · Cited by 382
Metadata
- Authors
- Santoro, B., Liu, D. T., Yao, H., Bartsch, D., Kandel, E. R., Siegelbaum, S. A., & Tibbs, G. R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 93
- Issue
- 5
- Pages
- 717-729
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2010973571
- Cited by
- 704
- References
- 1
- FWCI
- 13.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Santoro, B., Liu, D. T., Yao, H., Bartsch, D., Kandel, E. R., Siegelbaum, S. A., & Tibbs, G. R. (1998). Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain. Cell. https://doi.org/10.1016/s0092-8674(00)81434-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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