The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Prefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic Chaperonin
Open accessAbstract
We describe the discovery of a heterohexameric chaperone protein, prefoldin, based on its ability to capture unfolded actin. Prefoldin binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. Deletion of the gene encoding a prefoldin subunit in S. cerevisiae results in a phenotype similar to those found when c-cpn is mutated, namely impaired functions of the actin and tubulin-based cytoskeleton. Consistent with prefoldin having a general role in chaperonin-mediated folding, we identify homologs in archaea, which have a class II chaperonin but contain neither actin nor tubulin. We show that by directing target proteins to chaperonin, prefoldin promotes folding in an environment in which there are many competing pathways for nonnative proteins.
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Cites
Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.
Woese, C. R., Kandler, O., & Wheelis, M. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4576 · Cited by 6,128
The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo
Sternlicht, H., Farr, G. W., Sternlicht, M. L., Driscoll, J. K., Willison, K., & Yaffe, M. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9422 · Cited by 341
Cited by
Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
Hartl, F. U., & Hayer-Hartl, M. (2002) · Science · doi:10.1126/science.1068408 · Cited by 3,347
The tubulin code: Molecular components, readout mechanisms, and functions
Janke, C. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201406055 · Cited by 532
Two Families of Chaperonin: Physiology and Mechanism
Horwich, A. L., Fenton, W. A., Chapman, E., & Farr, G. W. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123555 · Cited by 422
A Gene Expression Profile of Alzheimer's Disease
Loring, J. F., Wen, X., Lee, J. M., Seilhamer, J., & Somogyi, R. (2001) · DNA and Cell Biology · doi:10.1089/10445490152717541 · Cited by 300
Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas
Hodgson, G., Hager, J. H., Volik, S., Hariono, S., Wernick, M., Moore, D., Albertson, D. G., Pinkel, D., Collins, C., Hanahan, D., et al. (2001) · Nature Genetics · doi:10.1038/ng771 · Cited by 294
Metadata
- Authors
- Vainberg, I. E., Lewis, S. A., Rommelaere, H., Ampe, C., Vandekerckhove, J., Klein, H. L., & Cowan, N. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 93
- Issue
- 5
- Pages
- 863-873
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2015040639
- Cited by
- 565
- References
- 2
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Vainberg, I. E., Lewis, S. A., Rommelaere, H., Ampe, C., Vandekerckhove, J., Klein, H. L., & Cowan, N. J. (1998). Prefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic Chaperonin. Cell. https://doi.org/10.1016/s0092-8674(00)81446-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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