The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
A Gene Expression Profile of Alzheimer's Disease
Abstract
Postmortem analysis of brains of patients with Alzheimer's disease (AD) has led to diverse theories about the causes of the pathology, suggesting that this complex disease involves multiple physiological changes. In an effort to better understand the variety and integration of these changes, we generated a gene expression profile for AD brain. Comparing affected and unaffected brain regions in nine controls and six AD cases, we showed that 118 of the 7050 sequences on a broadly representative cDNA microarray were differentially expressed in the amygdala and cingulate cortex, two regions affected early in the disease. The identity of these genes suggests the most prominent upregulated physiological correlates of pathology involve chronic inflammation, cell adhesion, cell proliferation, and protein synthesis (31 upregulated genes). Conversely, downregulated correlates of pathology involve signal transduction, energy metabolism, stress response, synaptic vesicle synthesis and function, calcium binding, and cytoskeleton (87 downregulated genes). The results support several separate theories of the causes of AD pathology, as well as add to the list of genes associated with AD. In addition, approximately 10 genes of unknown function were found to correlate with the pathology.
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Basic local alignment search tool
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Cited by
Blalock, E. M., Geddes, J. W., Chen, K. C., Porter, N. M., Markesbery, W. R., & Landfield, P. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308512100 · Cited by 1,025
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Circular RNA (circRNA) in Alzheimer’s disease (AD)
Lukiw, W. J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00307 · Cited by 636
“…systems” and ambient up-regulation of specific inducible miRNAs may help explain the widely observed, generalized and progressive down-regulation of gene expression that is characteristic of the sporadic AD brain (Loring et al., 2001; Colangelo et al., 2002; Ginsberg et al., 2012; Lukiw, 2013).”
BackgroundInfluentialThe role of tau in neurodegeneration
Gendron, T. F., & Petrucelli, L. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-13 · Cited by 478
Liu, F., Shi, J., Tanimukai, H., Gu, J., Gu, J., Grundke-Iqbal, I., Iqbal, K., & Gong, C.-X. (2009) · Brain · doi:10.1093/brain/awp099 · Cited by 439
Metadata
- Authors
- Loring, J. F., Wen, X., Lee, J. M., Seilhamer, J., & Somogyi, R.
- Venue
- DNA and Cell Biology
- Publisher
- SAGE Publications
- Published
- 2001-11
- Volume
- 20
- Issue
- 11
- Pages
- 683-695
- ISSN
- 1044-5498 (ISSN-L)
- 1557-7430
- OpenAlex
- W2088997949
- Cited by
- 300
- References
- 120
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Loring, J. F., Wen, X., Lee, J. M., Seilhamer, J., & Somogyi, R. (2001). A Gene Expression Profile of Alzheimer's Disease. DNA and Cell Biology. https://doi.org/10.1089/10445490152717541
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