The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Proteins of the CNR Family Are Multiple Receptors for Reelin
Open accessAbstract
Layering and positioning of neurons require Reelin- and Src family-associated mammalian Disabled (mDab1). Cadherin-related neuronal receptor (CNR) genes are expressed in neurons of the cortical layer, but not in Cajal-Retzius cells expressing Reelin. This leads us to hypothesize that CNRs bound to Fyn of the Src family are receptors for Reelin. Herein we confirm the association and colocalization of CNR proteins with Reelin. This binding is blocked by CR-50 antibody against Reelin, as well as by monoclonal antibodies produced against CNRs. Both disturb the signaling pathway from Reelin to mDab1 and the positioning of cortical neurons in vitro. These results strongly suggest that the CNR family proteins are multiple Reelin receptors. In addition, differential conservation of the Reelin-binding domain among terrestrial vertebrates may be pertinent to the diversity or complexity of brains.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Because the Dab1 phosphorylation is essential in Reelin signaling (24, 35–37)”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [37]
In the citing paper
“Recently, lipoprotein receptors (VLDLR and ApoER2) and the CNR family members were reported to bind to the full-length Reelin (35–37).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [37]
In the citing paper
“the CNR proteins bind to the subrepeat B of the first Reelin repeat, which is downstream of the CR-50 epitope region (37).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [37]
In the citing paper
“CR-50 antibody inhibited Reelin binding to VLDLR-expressing 293T cells (35) and to the extracellular domain of CNR1 protein (37).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [37]
Citations
Cites
Signaling Through Scaffold, Anchoring, and Adaptor Proteins
Pawson, T., & Scott, J. D. (1997) · Science · doi:10.1126/science.278.5346.2075 · Cited by 2,256
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
D'Arcangelo, G., G. Miao, G., Chen, S.-C., Scares, H. D., Morgan, J. I., & Curran, T. (1995) · Nature · doi:10.1038/374719a0 · Cited by 1,748
pEF-BOS, a powerful mammalian expression vector
Mizushima, S., & Nagata, S. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.17.5322 · Cited by 1,594
RAKIC, P. T. (1971) · The Journal of Comparative Neurology · doi:10.1002/cne.901410303 · Cited by 1,343
CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION
Takeichi, M. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.001321 · Cited by 1,301
Neuropilin is a semaphorin III receptor.
Kolodkin, A., Levengood, D. V., Rowe, E. G., Tai, Y.-T., Giger, R., & Ginty, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80535-8 · Cited by 1,262
Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A., & Herz, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80782-5 · Cited by 1,261
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
Grant, S. G. N., O’Dell, T. J., Karl, K. A., Stein, P. L., Soriano, P. M., & Kandel, E. R. (1992) · Science · doi:10.1126/science.1361685 · Cited by 1,160
Schaeren‐Wiemers, N., & Gerfin-Moser, A. (1993) · Histochemistry and Cell Biology · doi:10.1007/bf00267823 · Cited by 1,151
Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III
He, Z., & Tessier‐Lavigne, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80534-6 · Cited by 1,137
Research works printed but not linked: 1
- Yagi, 1999, Molecular mechanisms of Fyn-tyrosine kinase for regulating mammalian behaviors and ethanol sensitivity, Biochem. Pharmacol., 57, 845
Cited by
Sorted by citations
Items 201–273 of 273
Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections
Su, J., Klemm, M. A., Josephson, A. M., & Fox, M. A. (2013) · Neural Development · doi:10.1186/1749-8104-8-11 · Cited by 20
Biospecific Interaction Analysis
Gambari, R. (2001) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200101020-00005 · Cited by 19
Xu, M. F., Arnaud, L., & Cooper, J. A. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.06.001 · Cited by 18
Protocadherin α3 Acts at Sites Distinct from Classic Cadherins in Rat Testis and Sperm1
Johnson, K. J., Zecevic, A., & Kwon, E. J. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.021758 · Cited by 18
Cluster formation of α7-containing nicotinic receptors at interneuronal interfaces in cell culture
Conroy, W. G., Ogden, L. F., & Berg, D. K. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00132-5 · Cited by 18
Restricted expression of protocadherin 2A in the developing mouse brain
Hirano, S., Wang, X., & Suzuki, S. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00317-5 · Cited by 18
The Role of Cadherins in Ca2+-Mediated Cell Adhesion and Inherited Photoreceptor Degeneration
Bolz, H. J., Reiners, J., Uwe Wolfrum, B., & Gal, A. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0121-3_24 · Cited by 17
Cadherin-related Neuronal Receptors in Incisor Development
Fukumoto, E., Sakai, H., Fukumoto, S., Yagi, T., Takagi, O., & Kato, Y. (2003) · Journal of Dental Research · doi:10.1177/154405910308200105 · Cited by 16
Self-citationHistological study in the brain of the reelin/Dab1-compound mutant mouse
Yamamoto, T., Setsu, T., Okuyama‐Yamamoto, A., & Terashima, T. (2009) · Anatomical Science International · doi:10.1007/s12565-008-0009-7 · Cited by 16
Heymann, R., Kallenbach, S., Alonso, S., Carroll, P., & Mitsiadis, T. A. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00433-6 · Cited by 16
Nie, F., Zhang, Q., Ma, J., Wang, P., Gu, R., Han, J., & Zhang, R. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15225 · Cited by 16
Nakamura, Y., Yamamoto, M., & Kumamaru, E. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03170-5 · Cited by 15
Developmental Biology: Frontiers for Clinical Genetics
McInnes, R. R. (1998) · Clinical Genetics · doi:10.1111/j.1399-0004.1998.tb02667.x · Cited by 15
mRNA isoform balance in neuronal development and disease
LaForce, G. R., Philippidou, P., & Schaffer, A. E. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1762 · Cited by 15
Cerebral gyral dysplasias: molecular genetics and cell biology
Clark, G. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200104000-00004 · Cited by 13
An hypothesis on the early evolution of the development of the isocortex
Aboitiz, F., Montiel, J. F., & López, J. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00681-5 · Cited by 12
Mathematical model of early Reelin-induced Src family kinase-mediated signaling
Hass, H., Kipkeew, F., Gauhar, A., Bouché, E., May, P., Timmer, J., & Bock, H. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186927 · Cited by 10
Wu, Z., Yu, J., Wang, N., Yu, N., Zhang, Q., Chen, W., Zhang, W., Zhu, Q.-X., & Tan, L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.008 · Cited by 11
Rat neurological disease creeping is caused by a mutation in the reelin gene
Yokoi, N., Namae, M., Wang, H., Kojima, K., Fuse, M., Yasuda, K., Serikawa, T., Seino, S., & Komeda, K. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00650-2 · Cited by 12
A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain
Garcı́a-Frigola, C., Burgaya, F., Calbet, M., López‐Doménech, G., de Lecea, L., & Soriano, E. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.12.014 · Cited by 10
Poluch, S., & Juliano, S. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013709 · Cited by 10
Jiang, X., Li, S., Ravi, V., Venkatesh, B., & Yu, W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007614 · Cited by 10
The Extracellular Matrix in Neural Development, Plasticity, and Regeneration
Garwood, J., Heck, N., Rigato, F., & Faissner, A. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-108-4_5 · Cited by 11
Altered Gene Expression in the Adult Brain of fyn-Deficient Mice
Goto, J., Tezuka, T., Nakazawa, T., Tsukamoto, N., Nakamura, T., Ajima, R., Yokoyama, K., Ohta, T., Ohki, M., & Yamamoto, T. S. (2004) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000012720.71630.14 · Cited by 10
Setsu, T., Ikeda, Y., Woodhams, P. L., & Terashima, T. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1350 · Cited by 10
Evidence of Reelin Signaling in GBM and Its Derived Cancer Stem Cells
Biamonte, F., Sica, G., Filippini, A., & D’Alessio, A. (2021) · Brain Sciences · doi:10.3390/brainsci11060745 · Cited by 10
Transgenic and Gene “Knockout” Models in Alcohol Research
Hoffman, P. L., Yagi, T., Tabakoff, B., Phillips, T. J., Kono, H., Messing, R. O., & Choi, D. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02375.x · Cited by 9
Self-citationTransgenic and Gene ???Knockout??? Models in Alcohol Research
Hoffman, P. L., Yagi, T., Tabakoff, B., Phillips, T. J., Kono, H., Messing, R. O., & Choi, D. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200105051-00011 · Cited by 9
Self-citationCytoplasmic Tail Adaptors of Alzheimer's Amyloid-β Protein Precursor
Kawasumi, M., Matsuda, S., Matsuoka, M., & Nishimoto, I. (2004) · Molecular Neurobiology · doi:10.1385/mn:30:2:185 · Cited by 9
Kamitori, K., Machide, M., Tomita, K., Nakafuku, M., & Kohsaka, S. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00358-3 · Cited by 8
Li, Z., Wang, X., Yang, Y., Shi, F., Zhang, W., Wang, Q., & Wang, S. (2022) · Cells · doi:10.3390/cells11233841 · Cited by 7
Krahn, M. P., Rizk, S. E., Alfalah, M., Behrendt, M., & Naim, H. Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.080051 · Cited by 7
New Light on a Long‐Known Protein Family
Andersen, O. M., & Petersen, H. H. (2003) · ChemBioChem · doi:10.1002/cbic.200300580 · Cited by 6
Protocadherins and Synapse Development
Weiner, J. A. (2006) · Springer eBooks · doi:10.1007/978-0-387-32562-0_10 · Cited by 6
Vinay, P., Balamurugan, K., & Rajan, K. E. (2022) · Developmental Neuroscience · doi:10.1159/000525821 · Cited by 6
Brain Malformations Associated with Cell Migration
Nasrallah, I. M., & Golden, J. A. (2006) · Pediatric and Developmental Pathology · doi:10.2350/06-04-0077.1 · Cited by 4
Semb, H. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-68170-0_3 · Cited by 4
Sargent, C. A., Blanco, P., & Affara, N. A. (2004) · British Academy eBooks · doi:10.5871/bacad/9780197263112.003.0013 · Cited by 4
Jossin, Y. (2008) · Springer eBooks · doi:10.1007/978-0-387-76761-1_3 · Cited by 3
Identification of γA‐like protocadherin expressed during chick development
Capehart, A. A., & Kern, C. B. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10670 · Cited by 3
Current topics in comparative developmental biology of vertebrate brains
Inoue, T., Nakamura, S., & Osumi, N. (2001) · Neuroscience Research · doi:10.1016/s0168-0102(01)00203-6 · Cited by 2
Diversity of the cadherin-related neuronal receptor family in the nervous system
Yagi, T., Tada, M., Tanaka, Y., Senzaki, K., Hirayama, T., Hamada, S., & Sugino, H. (2002) · International Congress Series · doi:10.1016/s0531-5131(02)01143-3 · Cited by 2
Self-citationGolden, J. A. (2018) · Wiley eBooks · doi:10.1002/9781119013112.ch6 · Cited by 2
Hu, H. (2006) · doi:10.1093/acprof:oso/9780195183139.003.0003 · Cited by 2
Topical Review: Neuronal Migration in Developmental Disorders
McManus, M. F., & Golden, J. A. (2004) · Journal of Child Neurology · doi:10.1177/08830738040190030301 · Cited by 1
Gomes, F. C. A., & Rehen, S. K. (2003) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(03)31004-5 · Cited by 1
An interdisciplinary approach to brain evolution: A long due debate
Aboitiz, F., Morales, D., & Montiel, J. F. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03420128 · Cited by 1
Characterization of subtypes of precursor cells in the developing central nervous system
Hartfuss, E. (2003) · doi:10.5282/edoc.1391 · Cited by 1
Roles of the Nedd4 Family E3 Ligases in Glial Function and Nerve Cell Development
Altas, B. (2017) · doi:10.53846/goediss-6288 · Cited by 1
Alzheimer’s Disease and Reelin
Botella-López, A., & Sáez‐Valero, J. (2008) · Springer eBooks · doi:10.1007/978-0-387-76761-1_26 · Cited by 1
Blake, S. M. (2008) · University of Vienna · doi:10.25365/thesis.3555
Molecular development and laminar distribution of GABAergic interneurons of the cerebral cortex
Lodato, S. (2011) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/8450
Neurogênese e esquizofrenia: estudo molecular de associação
Purim, S. G. (2006) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2006.tde-12022007-150206
Molekulare Mechanismen von Zell-Zell-Wechselwirkungen
Brümmendorf, T. (2003) · Springer eBooks · doi:10.1007/978-3-662-07588-3_8
Aberrant structural and functional plasticity in the adult hippocampus of amygdala kindled rats
Fournier, N. M. (2009) · University Library - University of Saskatchewan (University of Saskatchewan)
Isolation und Charakterisierung möglicher intrazellulärer Interaktionspartner muriner Protocadherine
Weimann, K. (2010) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-7170
Role of Reelin in synaptogenesis and synaptic stabilization in the adult brain
Piñol, C. B. (2014) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
Der Reelin-Signalweg und die Ausbildung der Zell- und Faserschichten der Hirnrinde
Frotscher, M. (2001) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/s0940-9602(01)80055-8
Other Genes Implicated in Alzheimer’s Disease
Carrasquillo, M. M., Allen, M., & Ertekin‐Taner, N. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7309-1_12
morphogenesisin development: cell adhesion, sorting, and tissue
Halbleib, J. M., & Nelson, W. J. (2009)
Klempan, T. A., Muglia, P., & Kennedy, J. L. (2004) · Cambridge University Press eBooks · doi:10.1017/cbo9780511735103.003
Review Molecular mechanisms of lipoprotein receptor signalling
Herz, J., & Bock, H. H. (2005)
Review d-Protocadherins: unique structures and functions
Redies, C., Vanhalst, K., & Roy, F. M. V. (2005)
Clinical Aspects of the Inherited Cerebellar Malformations
Marzban, A., Vafaee‐Shahi, M., & Azarkhish, K. (2017) · Contemporary clinical neuroscience · doi:10.1007/978-3-319-59749-2_19
Heymann, R., Kallenbach, S., Alonso, S., Carroll, P., & Mitsiadis, T. A. (2001)
From inside-out to outside-in: cortical lamination development in the Reelin-deficient neocortex
Mingo-Moreno, N. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7335
Clinical Aspects of the Inherited Cerebellar Malformations
Marzban, A., Ghiyamihoor, F., Vafaee‐Shahi, M., & Azarkhish, K. (2023) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-23104-9_22
Somatic mutations of synaptic cadherin (CNR family) transcripts in the nervous system
Hirayama, T. (n.d.) · Institutional Repositories DataBase (IRDB)
Megalin, an endocytotic receptor with signalling potential.
Larsson, M. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Herman (2000) · doi:10.1002/1096-9861(20000703)422:3
Metadata
- Authors
- Senzaki, K., Ogawa, M., & Yagi, T.
- Affiliations
- National Institute for Physiological Sciences (JP)
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Yagi, Takeshi
- ORCID
- Yagi, Takeshi
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 99
- Issue
- 6
- Pages
- 635-647
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2056281513
- Cited by
- 272
- References
- 45
- Citations by year
- 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 14.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Core Research for Evolutional Science and Technology
- Japan Science and Technology Corporation
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- reelin, Reelin receptors, Fyn, Src family kinases, protein colocalization, brain evolution
- MeSH terms
- Reelin Protein, Protocadherins, Animals, Cells, Cultured, Cerebral Cortex, Humans, Mice, Inbred Strains, Nerve Tissue Proteins, Neurons, Neuropeptides, Protein Binding, Rats, Inbred F344, Receptors, Cell Surface, Sensory Receptor Cells, Serine Endopeptidases, Cell Adhesion Molecules, Neuronal, Cadherins, Extracellular Matrix Proteins, In Situ Hybridization, Protein Structure, Tertiary, Evolution, Molecular, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
