The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Proteins of the CNR Family Are Multiple Receptors for Reelin
Open accessAbstract
Layering and positioning of neurons require Reelin- and Src family-associated mammalian Disabled (mDab1). Cadherin-related neuronal receptor (CNR) genes are expressed in neurons of the cortical layer, but not in Cajal-Retzius cells expressing Reelin. This leads us to hypothesize that CNRs bound to Fyn of the Src family are receptors for Reelin. Herein we confirm the association and colocalization of CNR proteins with Reelin. This binding is blocked by CR-50 antibody against Reelin, as well as by monoclonal antibodies produced against CNRs. Both disturb the signaling pathway from Reelin to mDab1 and the positioning of cortical neurons in vitro. These results strongly suggest that the CNR family proteins are multiple Reelin receptors. In addition, differential conservation of the Reelin-binding domain among terrestrial vertebrates may be pertinent to the diversity or complexity of brains.
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In the citing paper
“Because the Dab1 phosphorylation is essential in Reelin signaling (24, 35–37)”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [37]
In the citing paper
“Recently, lipoprotein receptors (VLDLR and ApoER2) and the CNR family members were reported to bind to the full-length Reelin (35–37).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [37]
In the citing paper
“the CNR proteins bind to the subrepeat B of the first Reelin repeat, which is downstream of the CR-50 epitope region (37).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [37]
In the citing paper
“CR-50 antibody inhibited Reelin binding to VLDLR-expressing 293T cells (35) and to the extracellular domain of CNR1 protein (37).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [37]
Citations
Cites
Signaling Through Scaffold, Anchoring, and Adaptor Proteins
Pawson, T., & Scott, J. D. (1997) · Science · doi:10.1126/science.278.5346.2075 · Cited by 2,256
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
D'Arcangelo, G., G. Miao, G., Chen, S.-C., Scares, H. D., Morgan, J. I., & Curran, T. (1995) · Nature · doi:10.1038/374719a0 · Cited by 1,748
pEF-BOS, a powerful mammalian expression vector
Mizushima, S., & Nagata, S. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.17.5322 · Cited by 1,594
RAKIC, P. T. (1971) · The Journal of Comparative Neurology · doi:10.1002/cne.901410303 · Cited by 1,343
CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION
Takeichi, M. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.001321 · Cited by 1,301
Neuropilin is a semaphorin III receptor.
Kolodkin, A., Levengood, D. V., Rowe, E. G., Tai, Y.-T., Giger, R., & Ginty, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80535-8 · Cited by 1,262
Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A., & Herz, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80782-5 · Cited by 1,261
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
Grant, S. G. N., O’Dell, T. J., Karl, K. A., Stein, P. L., Soriano, P. M., & Kandel, E. R. (1992) · Science · doi:10.1126/science.1361685 · Cited by 1,160
Schaeren‐Wiemers, N., & Gerfin-Moser, A. (1993) · Histochemistry and Cell Biology · doi:10.1007/bf00267823 · Cited by 1,151
Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III
He, Z., & Tessier‐Lavigne, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80534-6 · Cited by 1,137
Current Protocols in Human Genetics
Schutte, B. C., & Murray, J. C. (2001) · John Wiley & Sons, Inc. eBooks · doi:10.1002/0471142905 · Cited by 1,091
Francis, F., Koulakoff, A., Boucher, D., Chafey, P., Schaar, B. T., Vinet, M. C., Friocourt, G., McDonnell, N., Reiner, O., Kahn, A., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80777-1 · Cited by 1,014
Hiesberger, T., Trommsdorff, M., Howell, B. W., Goffinet, A., Mumby, M. C., Cooper, J. A., & Herz, J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80861-2 · Cited by 916
Ogawa, M., Miyata, T., Nakajimat, K., Yagyu, K., Seike, M., Ikenaka, K., Yamamoto, H., & Mikoshibat, K. (1995) · Neuron · doi:10.1016/0896-6273(95)90329-1 · Cited by 889
Self-citationReelin Is a Ligand for Lipoprotein Receptors
D'Arcangelo, G., Homayouni, R., Keshvara, L., Rice, D. S., Sheldon, M., & Curran, T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80860-0 · Cited by 808
The kit ligand: A cell surface molecule altered in steel mutant fibroblasts
Flanagan, J. G., & Leder, P. (1990) · Cell · doi:10.1016/0092-8674(90)90299-t · Cited by 747
A Striking Organization of a Large Family of Human Neural Cadherin-like Cell Adhesion Genes
Wu, Q., & Maniatis, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80789-8 · Cited by 722
Developmental changes in distribution of NMDA receptor channel subunit mRNAs
Watanabe, M., Inoue, Y., Sakimura, K., & Mishina, M. (1992) · Neuroreport · doi:10.1097/00001756-199212000-00027 · Cited by 721
Neuronal position in the developing brain is regulated by mouse disabled-1
Howell, B. W., Hawkes, R., Soriano, P., & Cooper, J. A. (1997) · Nature · doi:10.1038/39607 · Cited by 692
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
Gao, Y., Sun, Y., Frank, K. M., Dikkes, P., Fujiwara, Y., Seidl, K. J., Sekiguchi, J. M., Rathbun, G. A., Swat, W., Wang, J., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81714-6 · Cited by 688
Variants of the cell recognition site of fibronectin that retain attachment-promoting activity.
Pierschbacher, M. D., & Ruoslahti, E. I. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.5985 · Cited by 683
Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice
Sheldon, M., Rice, D. S., D'Arcangelo, G., Yoneshima, H., Nakajima, K., Mikoshiba, K., Howell, B. W., Cooper, J. A., Goldowitz, D., & Curran, T. (1997) · Nature · doi:10.1038/39601 · Cited by 638
Widespread Dispersion of Neuronal Clones Across Functional Regions of the Cerebral Cortex
Walsh, C. A., & Cepko, C. L. (1992) · Science · doi:10.1126/science.1734520 · Cited by 613
Alcántara, S., Ruiz, M., D’Arcangelo, G., Ezan, F., de Lecea, L., Curran, T., Sotelo, C., & Soriano, E. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07779.1998 · Cited by 568
Falconer, D. S. (1951) · Journal of Genetics · doi:10.1007/bf02996215 · Cited by 539
Reelin Is a Secreted Glycoprotein Recognized by the CR-50 Monoclonal Antibody
D’Arcangelo, G., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., & Curran, T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00023.1997 · Cited by 515
Self-citationCurrent protocols in human genetics
Bates, G. P. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89147-7 · Cited by 484
A role for Cajal–Retzius cells and reelin in the development of hippocampal connections
Del Río, J. A., Heimrich, B., Borrell, V., Förster, E., Drakew, A., Alcántara, S., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., et al. (1997) · Nature · doi:10.1038/385070a0 · Cited by 472
Self-citationCajal–Retzius cells and the development of the neocortex
Marín‐Padilla, M. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01164-8 · Cited by 444
Diversity Revealed by a Novel Family of Cadherins Expressed in Neurons at a Synaptic Complex
Kohmura, N., Senzaki, K., Hamada, S., Kai, N., Yasuda, R., Watanabe, M., Ishii, H., Yasuda, M., Mishina, M., & Yagi, T. (1998) · Neuron · doi:10.1016/s0896-6273(00)80495-x · Cited by 444
Self-citationReelin-induced tryosine phosphorylation of Disabled 1 during neuronal positioning
Howell, B. W., Herrick, T. M., & Cooper, J. A. (1999) · Genes & Development · doi:10.1101/gad.13.6.643 · Cited by 411
The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity
Nikolić, M., Chou, M. M., Lu, W., Mayer, B. J., & Tsai, L. (1998) · Nature · doi:10.1038/26034 · Cited by 404
Mouse disabled (mDab1): a src binding protein implicated in neuronal development
Howell, B. W., Gertler, F. B., & Cooper, J. A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.1.121 · Cited by 287
Motility and cytoskeletal organization of migrating cerebellar granule neurons
Rivas, R., & Hatten, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-02-00981.1995 · Cited by 279
Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk
Prince, V., Joly, L., Ekker, M., & Ho, R. K. (1998) · Development · doi:10.1242/dev.125.3.407 · Cited by 252
Curran, T., & D'Arcangelo, G. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00035-0 · Cited by 246
Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex
Komuro, H., & RAKIC, P. T. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01478.1998 · Cited by 233
Histogenesis of fetal mouse isocortex and hippocampus in reaggregating cell cultures
DeLong, G. R. (1970) · Developmental Biology · doi:10.1016/0012-1606(70)90169-7 · Cited by 181
Disruption of hippocampal development in vivo by CR-50 mAb against Reelin
Nakajima, K., Mikoshiba, K., Miyata, T., Kudo, C., & Ogawa, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8196 · Cited by 171
Self-citationGenomic Organization of the Family of CNR Cadherin Genes in Mice and Humans
Sugino, H., Hamada, S., Yasuda, R., Tuji, A., Matsuda, Y., Fujita, M., & Yagi, T. (2000) · Genomics · doi:10.1006/geno.1999.6066 · Cited by 116
Self-citationPolarity of microtubule assemblies during neuronal cell migration.
RAKIC, P. T., Knyihár‐Csillik, E., & Csillik, B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9218 · Cited by 114
Identification of a Binding Site for Integrin αEβ7 in the N-terminal Domain of E-cadherin
Karecla, P. I., Green, S. J., Bowden, S. J., Coadwell, J., & Kilshaw, P. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.48.30909 · Cited by 84
Yagi, T., Shigetani, Y., Okado, N., Tokunaga, T., Ikawa, Y., & Aizawa, S. (1993) · PubMed · Cited by 71
Self-citationHox gene variation and evolution
Meyer, A. (1998) · Nature · doi:10.1038/34530 · Cited by 59
Yagi, T. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00309-8 · Cited by 49
Self-citation
Research works printed but not linked: 1
- Yagi, 1999, Molecular mechanisms of Fyn-tyrosine kinase for regulating mammalian behaviors and ethanol sensitivity, Biochem. Pharmacol., 57, 845
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Comparative Genomics of the Eukaryotes
Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698
Cadherins in development: cell adhesion, sorting, and tissue morphogenesisPreprint
Halbleib, J. M., & Nelson, W. J. (2006) · Genes & Development · doi:10.1101/gad.1486806 · Cited by 1,101
C ELL M IGRATION IN THE F OREBRAIN
Marín, Ó., & Rubenstein, J. L. R. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131058 · Cited by 957
Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations
Hong, S. E., Shugart, Y. Y., Huang, D. T.-C., Shahwan, S. A., Grant, P. E., Hourihane, J. O., Martin, N. D. T., & Walsh, C. A. (2000) · Nature Genetics · doi:10.1038/79246 · Cited by 896
Metadata
- Authors
- Senzaki, K., Ogawa, M., & Yagi, T.
- Affiliations
- National Institute for Physiological Sciences (JP)
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Yagi, Takeshi
- ORCID
- Yagi, Takeshi
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 99
- Issue
- 6
- Pages
- 635-647
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2056281513
- Cited by
- 272
- References
- 45
- Citations by year
- 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 14.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Core Research for Evolutional Science and Technology
- Japan Science and Technology Corporation
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- reelin, Reelin receptors, Fyn, Src family kinases, protein colocalization, brain evolution
- MeSH terms
- Reelin Protein, Protocadherins, Animals, Cells, Cultured, Cerebral Cortex, Humans, Mice, Inbred Strains, Nerve Tissue Proteins, Neurons, Neuropeptides, Protein Binding, Rats, Inbred F344, Receptors, Cell Surface, Sensory Receptor Cells, Serine Endopeptidases, Cell Adhesion Molecules, Neuronal, Cadherins, Extracellular Matrix Proteins, In Situ Hybridization, Protein Structure, Tertiary, Evolution, Molecular, Mice, Rats
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