The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells
Open accessAbstract
Post HIV-1 entry, productive HIV-1 infection of primary T cells requires overcoming several cellular blocks to provirus establishment and replication. Activation of unknown host intracellular events overcomes such inhibitory steps and is concomitant with HIV-1 replication. We show that the transcription factor NFATc was sufficient as a cellular factor to induce a highly permissive state for HIV-1 replication in primary CD4+ T cells. NFATc overcame a blockade at reverse transcription and permitted active HIV-1 replication. Pharmacologic blockade of endogenous NFAT activity by FK506 or CsA inhibited synthesis of reverse transcription and also potently blocked HIV-1 replication. T cells therefore can become competent for HIV-1 replication by control of regulated host factors such as the NFATc transcription factor. The host mechanisms regulated by such permissivity factors are potential targets for anti-HIV-1 therapy.
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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116
Specific incorporation of cyclophilin A into HIV-1 virions
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Cited by
Crabtree, G. R., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00699-2 · Cited by 1,323
Hunt, P. W., Martin, J. N., Sinclair, E., Bredt, B., Hagos, E., Lampiris, H., & Deeks, S. G. (2003) · The Journal of Infectious Diseases · doi:10.1086/374786 · Cited by 852
HIV and Tuberculosis: a Deadly Human Syndemic
Kwan, C. K., & Ernst, J. D. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-10 · Cited by 720
Siliciano, R. F., & Greene, W. C. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007096 · Cited by 513
Stevenson, M. (2003) · Nature Medicine · doi:10.1038/nm0703-853 · Cited by 441
Metadata
- Authors
- Kinoshita, S., Chen, B. K., Kaneshima, H., & Nolan, G. P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 95
- Issue
- 5
- Pages
- 595-604
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2086693765
- Cited by
- 227
- References
- 3
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kinoshita, S., Chen, B. K., Kaneshima, H., & Nolan, G. P. (1998). Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells. Cell. https://doi.org/10.1016/s0092-8674(00)81630-x
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