NFAT Signaling
Open accessAbstract
Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA. Nuclear import is opposed by kinases such as GSK3, thereby rendering transcription continuously responsive to receptor occupancy. Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions.
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In the canonical NFAT pathway, Ca2+/Calcineurin mediates nuclear translocation of NFAT through the dephosphorylation of multiple serine residues in the N-terminus region, including the nuclear localization signal.
“In the canonical NFAT pathway, Ca2+/Calcineurin mediates nuclear translocation of NFAT through the dephosphorylation of multiple serine residues in the N-terminus region, including the nuclear localization signal (34, 59, 60).”
From LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies (2020) · cites this paper as [34]
Cites
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“All NFAT proteins make very similar contacts with DNA but can have distinct expression patterns and functions as judged by the non-overlapping phenotypes ofmice deficient in individual NFAT family members (Crabtree and Olson, 2002; Hogan et al., 2003;Macian, 2005).”
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- Authors
- Crabtree, G. R., & Olson, E. N.
- Affiliations
- Howard Hughes Medical Institute (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Crabtree, Gerald R
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 109
- Issue
- 2
- Pages
- S67-S79
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1569503463
- Cited by
- 1,323
- References
- 2
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 28 · 2023: 28 · 2022: 38 · 2021: 43 · 2020: 40 · 2019: 45 · 2018: 49 · 2017: 38 · 2016: 37 · 2015: 55 · 2014: 49 · 2013: 56 · 2012: 78
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- NFAT signaling, calcineurin, calcium signaling, nuclear translocation, transcriptional regulation, nuclear import, receptor occupancy
- MeSH terms
- Animals, Cardiovascular System, DNA-Binding Proteins, Humans, Lymphocytes, Musculoskeletal System, Nuclear Proteins, Transcription Factors, Calcium Channels, Signal Transduction, Calcineurin, Calcium Signaling, Active Transport, Cell Nucleus, Feedback, Physiological, Musculoskeletal Development, Macromolecular Substances, NFATC Transcription Factors
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