Cited by 357Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNitric Oxide and Endothelin Effects

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Nitric Oxide Acts Directly in the Presynaptic Neuron to Produce Long-Term Potentiationin Cultured Hippocampal Neurons

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Arancio, Ottavio, Kiebler, Michael, Lee, C.Justin, Lev-Ram, Varda, Tsien, Roger Y, Kandel, Eric R, Hawkins, Robert D·1996·Cell

DOI 10.1016/s0092-8674(00)81797-3

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Abstract

Nitric oxide (NO) has been proposed to act as a retrograde messenger during long-term potentiation (LTP) in the CA1 region of hippocampus, but the inaccessibility of the presynaptic terminal has prevented a definitive test of this hypothesis. Because both sides of the synapse are accessible in cultured hippocampal neurons, we have used this preparation to investigate the role of NO. We examined LTP following intra- or extracellular application of an NO scavenger, an inhibitor of NO synthase, and a membrane-impermeant NO donor that releases NO only upon photolysis with UV light. Our results indicate that NO is produced in the postsynaptic neuron, travels through the extracellular space, and acts directly in the presynaptic neuron to produce long-term potentiation, supporting the hypothesis that NO acts as a retrograde messenger during LTP.

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Authors: Arancio, O., Kiebler, M., Lee, C. J., Lev-Ram, V., Tsien, R. Y., Kandel, E. R., & Hawkins, R. D.
Affiliations: Columbia University (US)
Howard Hughes Medical Institute (US)
New York State Psychiatric Institute (US)
Corresponding author: Hawkins, Robert D
ORCID: Arancio, Ottavio
Kiebler, Michael
Lee, C.Justin
Kandel, Eric R
Venue: Cell
Publisher: Elsevier BV
Published: 1996-12
Volume: 87
Issue: 6
Pages: 1025-1035
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)81797-3
OpenAlex: W2102133195
Cited by: 357
References: 30
Citations by year: 2026: 5 · 2025: 3 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 14 · 2013: 13 · 2012: 11
FWCI: 8.37
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1592 d)
Locations: Cell (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (P50MH050733, MH-50733)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: nitric oxide, long-term potentiation, retrograde signaling, presynaptic neurons, hippocampal neurons, NO synthase inhibition, NO scavenger, CA1 region
MeSH terms: Animals, Cells, Cultured, Extracellular Space, Fluorescent Antibody Technique, Hippocampus, Membrane Potentials, Methemoglobin, Microinjections, Myoglobin, Neurons, Nitric Oxide, Photolysis, Tetanus Toxin, Ultraviolet Rays, Rats, Sprague-Dawley, Presynaptic Terminals, Long-Term Potentiation, Neurotransmitter Agents, Nitric Oxide Synthase, Rats

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Nitric Oxide Acts Directly in the Presynaptic Neuron to Produce Long-Term Potentiationin Cultured Hippocampal Neurons

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