Nitric Oxide Acts Directly in the Presynaptic Neuron to Produce Long-Term Potentiationin Cultured Hippocampal Neurons

A synaptic model of memory: long-term potentiation in the hippocampus

Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566

Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice

Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365

Evidence for silent synapses: Implications for the expression of LTP

Isaac, J. T. R., Nicoll, R. A., & Malenka, R. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90046-2 · Cited by 1,233

A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation

Schuman, E. M., & Madison, D. V. (1991) · Science · doi:10.1126/science.1720572 · Cited by 1,135

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.

O’Dell, T. J., Hawkins, R. D., Kandel, E. R., & Arancio, O. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11285 · Cited by 1,035

Presynaptic mechanism for long-term potentiation in the hippocampus

Bekkers, J. M., & Stevens, C. F. (1990) · Nature · doi:10.1038/346724a0 · Cited by 685

Possible involvement of nitric oxide in long-term potentiation

Böhme, G. A., Bon, C. L. M., Stutzmann, J. M., Doble, A., & Blanchard, J. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90505-k · Cited by 632

Hebbian synapses in hippocampus.

Kelso, S. R., Ganong, A. H., & Brown, T. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.14.5326 · Cited by 555

A Text-book of Quantitative Chemical Analysis

Cumming, A. C., & Kay, S. A. (1923) · Nature · doi:10.1038/111321c0 · Cited by 512

Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus

Zhuo, M., Small, S. A., Kandel, E. R., & Hawkins, R. D. (1993) · Science · doi:10.1126/science.8100368 · Cited by 467

Phosphodiesterase Inhibitors in Object Recognition and Object Location Memory Tests

Heckman, P. R. A., Argyrousi, E. K., & Prickaerts, J. (2018) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-812012-5.00038-0 · Cited by 4

Nitrergic Modulation of Hippocampal Acetylcholine Release Is Independent of Endothelial NO Synthase Activity

Buchholzer, M.-L., & Klein, J. (2003) · Neurochemical Research · doi:10.1023/a:1022885726287 · Cited by 4

Neuromodulation of Hippocampal Cells and Circuits

Lawrence, J. J., & Cobb, S. (2018) · Springer series in computational neuroscience · doi:10.1007/978-3-319-99103-0_7 · Cited by 4

Combinatory Approaches Targeting Cognitive Impairments and Memory Enhancement: A Review

Kale, P. P., & Gupta, V. S. (2022) · Current Drug Targets · doi:10.2174/1389450123666220928152743 · Cited by 5

Effects of chronic prenatal ethanol exposure on cGMP content and glutamate release in the hippocampus of the neonatal guinea pig

Butters, N. S., Reynolds, J. N., & Brien, J. F. (2003) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(02)00325-2 · Cited by 4

Genetic manipulation of cyclic nucleotide signaling during hippocampal neuroplasticity and memory formation

Kelly, M. P., Heckman, P. R. A., & Havekes, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101799 · Cited by 4

Trans-Synaptic Signalling by Nitric Oxide

Hall, C. N., & Garthwaite, J. (2007) · Springer eBooks · doi:10.1007/0-387-23696-1_19 · Cited by 4

Nitric oxide signaling in Alzheimer's disease: A double-edged sword

Wasim, R. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178986 · Cited by 3

Protein kinase G‐dependent mechanisms modulate hypoglossal motoneuronal excitability and long‐term facilitation

Saywell, S. A., Babiec, W. E., Neverova, N. V., & Feldman, J. L. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.194209 · Cited by 3

Genes and pathways associated with fear discrimination identified by genome-wide DNA methylation and RNA-seq analyses in nucleus accumbens in mice

Hao, B., Fan, B., Cao, C.-C., Liu, L., Xuan, S., Wang, L., Gao, Z.-J., Shi, Y., Wang, X., & Zhao, H. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110643 · Cited by 3

Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

Xu, Q., Zhu, Z., Xu, J., Gu, W., & Zhao, Z. (2012) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2012007500158 · Cited by 3

Nature of the bond, reduction potential, and solvation properties of ruthenium nitrosyl complexes of the type trans‐[Ru( NH3 )4(L)( NO )]2+/3+ and [Ru(salen)(L)( NO )]2+/3+ in different charge and spin states

Rodrigues, G. L. S., & Rocha, W. R. (2020) · International Journal of Quantum Chemistry · doi:10.1002/qua.26476 · Cited by 3

Nitric Oxide as a Neuronal Messenger

Jacklet, J. W. (2001) · Encyclopedia of Life Sciences · doi:10.1038/npg.els.0000288 · Cited by 3

Nanosensor Detection of Synaptic Glutamate Release and Its Enhancement in Long‐term Potentiation

Zhang, F., Gao, R., Tian, S., Yang, X., Qi, Y.-T., Wang, L., Zhang, X., & Huang, W. (2025) · Small Methods · doi:10.1002/smtd.202500783 · Cited by 2

Synaptic control of retinal ganglion cell survival and axon regeneration

Qiu, Y., Zhang, Q., Tang, J., Cheng, Y., Wang, Y., Wang, Z., Liu, X., Zhang, B., Liu, L., Yu, S., et al. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00929-1 · Cited by 3

Long-term potentiation in the brain: a synaptic memory mechanism

Moreno, A. R., & Paulsen, O. (2026) · Physiological Reviews · doi:10.1152/physrev.00028.2025 · Cited by 2

Characterization of peristaltic motility in the striated muscle portion of the esophagus using a novel in vivo method in rats

Horii, K., Shiina, T., Naitou, K., Nakamori, H., Horii, Y., Shimaoka, H., & Shimizu, Y. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13518 · Cited by 2

Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors

Borovac, J., Rai, J., Valencia, M., Li, H., Georgiou, J., Collingridge, G. L., Takao, K., & Okamoto, K. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1479360 · Cited by 2

Nos1+ neurons are critical for motor learning and post-stroke motor recovery

Lin, Y., Xu, X.-M., Lin, L., Deng, X.-H., Chen, W., Chen, M., Hou, Y.-L., Gao, F., Zhang, C.-J., Wu, H., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116322 · Cited by 2

Modulation of Adult Neurogenesis by the Nitric Oxide System

Bruno, P., Ana, I., Caetana, M., & Ins, M. (2013) · InTech eBooks · doi:10.5772/54982 · Cited by 2

Cellular and Molecular Mechanisms of Memory in Mollusks

Byrne, J. H., Hochner, B., & Kemenes, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21097-3 · Cited by 3

Measurement of the synthesis, turnover, and assembly of α- and β-erythroid and nonerythroid spectrins in cultured rat hippocampal neurons

Sangerman, J., & Goodman, S. R. (2001) · Brain Research Protocols · doi:10.1016/s1385-299x(00)00047-7 · Cited by 2

Beyond Erectile Dysfunction: Understanding PDE5 Activity In The Central Nervous System

Bollen, E., Rutten, K., Reneerkens, O. A. H., Steinbusch, H. W. M., & Prickaerts, J. (2014) · doi:10.1002/9781118836507.ch09 · Cited by 2

Nitric Oxide in Cell-to-Cell Communication Coordinating the Plant Hypersensitive Response

Shapiro, A. D. (2007) · Springer eBooks · doi:10.1007/7089_2006_094 · Cited by 2

Nitric oxide signalling in hippocampal synaptic plasticity

Pigott, B. M. (2012) · UCL Discovery (University College London) · Cited by 2

Nitrinergic Signalling in Object Novelty Recognition

Argyrousi, E. K., & Prickaerts, J. (2018) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-812012-5.00037-9 · Cited by 1

AMPA receptors in synaptic plasticity and learning and memory

Kim, K., & Park, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00056-0 · Cited by 1

Treatment with perampanel alleviates depression-like behavior in mice via modulating GluN2B expression to improve excitatory synaptic transmission

Liu, J.-M., Zhang, Y., Guo, F., Li, B.-W., Chen, H., Mo, Y., Kong, J., Tan, X., Wu, W., & Cao, X. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03874-1 · Cited by 1

Presynaptic Mechanisms of Plasticity and Memory in Aplysia and Other Learning-Related Experimental Systems

Hawkins, R. D., Bailey, C. H., & Kandel, E. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21111-5 · Cited by 1

Retrograde Messengers in Long-Term Plasticity of Presynaptic Glutamate Release in Hippocampus

Kyrozis, A., Benameur, K., Zhang, X., Winterer, J., Müller, W. S., & Stanton, P. K. (2005) · Springer eBooks · doi:10.1007/0-387-25443-9_17 · Cited by 1

The Role of Activity-Dependent Mechanisms in Pattern Formation in the Retinogeniculate Pathway

Leamey, C. A., Cramer, K. S., & Sur, M. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5333-5_17 · Cited by 1

Etude des effets mitochondriaux du monoxyde d'azote : Régulation de l'oxydation phosphorylante et de la transition de perméabilité

Clerc, P. (2006) · OpenGrey (Institut de l'Information Scientifique et Technique)

THE ROLES OF NITRIC OXIDE SIGNALING AND cAMP RESPONSE ELEMENT BINDING PROTEIN IN FEAR CONDITIONING By

Kelley, J. B., & Kelley, J. B. (2016)

Common and rare genetic risk factors for schizophrenia and their associations with cognition

Hubbard, L. (2014) · ORCA Online Research @Cardiff (Cardiff University)

Overview of the Pathway and Functions of Nitric Oxide

Dillman, J. F., Dawson, V. L., & Dawson, T. M. (1999) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx1001s00

Light‐Activated (Caged) Biological Ligands

Hess, G. P. (2002) · Encyclopedia of Molecular Biology · doi:10.1002/047120918x.emb0846

Sodium Nitroprusside Does Not Prevent an Inhibitory Effect of Carnosine on Long-Term Potentiation in the Dentate Gyrus of Rats

Dolu, N., Süer, C., Artış, S., Aydoğan, S., & Bitiktas, S. (2012) · Neurophysiology · doi:10.1007/s11062-012-9290-0

The role of hippocampal nitric oxide in passive avoidance learning

Harooni, H. E., Naghdi, N., Rohani, A. H., & Sepehri, H. (2009)

Aspects of the transcriptional and translational regulation of nitric oxide synthase 1.

Pierson, S. M. (2005) · OhioLink ETD Center (Ohio Library and Information Network)

Retrograde signalling within fear neurocircuitry: Nitric oxide signalling from the lateral nucleus of the amygdala regulates thalamic EGR-1 mediated alterations of presynaptic protein levels during auditory fear conditioning

Overeem, K. A. (2009) · UC Research Repository (University of Canterbury) · doi:10.26021/6592

Phosphodiesterase 5 inhibition on dopaminergic and glutamatergic neurotransmission: Implications for memory ehancement

Uthayathas, S. (2009)

Participação da serotonina no efeito tipo-antidepressivo induzido pela inibição da nNOS no hipocampo de ratos

Sato, V. (2011) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2011.tde-22062011-090727

The NO Signaling Pathway in the Brain: Neural Injury, Neurological Disorders, and Aggression

Sasaki, M., Dawson, V. L., & Dawson, T. M. (2003) · Humana Press eBooks · doi:10.1385/1-59259-019-5:151

Parallel éber plasticity

Hartell, N. A. (2002)

NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation

Patel, J. (2021) · IUScholarWorks (Indiana University) · doi:10.7912/c2/2085

The Gaseous Messenger NO: Its Functions in the Visual System.

Furukawa, T. (1998) · The Brain & Neural Networks · doi:10.3902/jnns.5.10

Consciousness

Bickle, J. (2003) · Springer eBooks · doi:10.1007/978-94-010-0237-0_4

Nitric Oxide as a Neuronal Messenger

Jacklet, J. W. (2005) · Encyclopedia of Life Sciences · doi:10.1038/npg.els.0004093

Functional spreading of hyperexcitability induced by human and synthetic intracellular Aβ oligomersPreprint

Fernández-Pérez, E. J., Muñoz, B., Bascuñán, D., Peters, C., Riffo-Lepe, N., Espinoza, M. P., Morgan, P. J., Filippi, C., Bourboulou, R., Sengupta, U., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.16.332445

A novel nitric oxide (NO)-dependent ‘molecular switch’ mediates LTP in the Octopus vulgaris brain through persistent activation of nitric oxide synthase (NOS)Preprint

Turchetti-Maia, A. L., Shomrat, T., Bidel, F., Stern‐Mentch, N., Nesher, N., & Hochner, B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.25.630295

Lactate phosphorylates nNOSSer1412 and protects against restraint stress-induced memory impairment in mice

Tomiga, Y., Kusano, M., Takano, A., Higaki, Y., & Takahashi, H. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120039

The NO Signaling Pathway in the Brain

Sasaki, M., Dawson, V. L., & Dawson, T. M. (2000) · doi:10.1007/978-1-59259-019-3_6

Effects of Acute High-Intensity Aerobic Exercise on Cognition: the Potential Roles of Motivation and Perceived Energy Levels

Jung, M., Hord, L., Patrick, Z., McMorris, T., Voss, M. W., Hillman, C. H., & Loprinzi, P. D. (2026) · Journal of Cognitive Enhancement · doi:10.1007/s41465-026-00348-6

Roles of astroglial cannabinoid type 1 receptors (CB1) in memory and synaptic plasticity

Robin, L. M. (2018) · theses.fr (ABES) · doi:10.70675/1fd1dda8z3f4bz404azbdf6z5b648e4c4053

Rôle de la phosphodiestérase 2A dans la physiopathologie du syndrome de l’X fragile

Delhaye, S. (2021) · theses.fr (ABES) · doi:10.70675/e0fac395z63d4z46a4z944aza4037215ca98

Neuromodulation and Synaptic Plasticity in the Dorsomedial Hypothalamus

Crosby, K. M. (2013) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/27085

Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons

Arancio, O., Lev‐Ram, V., Tsien, R. Y., Kandel, E. R., & Hawkins, R. D. (1996) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(97)87907-7 · Cited by 45

Nitric oxide as an intercellular signal in long-term potentiation

Schuman, E., & Madison, D. (1993) · Seminars in Neuroscience · doi:10.1016/s1044-5765(05)80054-5 · Cited by 18

A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation

Schuman, E. M., & Madison, D. V. (1991) · Science · doi:10.1126/science.1720572 · Cited by 1,135

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.

O’Dell, T. J., Hawkins, R. D., Kandel, E. R., & Arancio, O. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11285 · Cited by 1,035

A Role for Nitric Oxide in Long‐term Potentiation

Bon, C. L. M., Böhme, G., Doble, A., Stutzmann, J., & Blanchard, J. (1992) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1992.tb00891.x · Cited by 156