Oligomeric Complexes Link Rab5 Effectors with NSF and Drive Membrane Fusion via Interactions between EEA1 and Syntaxin 13

SNAREpins: Minimal Machinery for Membrane Fusion

Weber, T., Zemelman, B. V., McNew, J. A., Westermann, B., Gmachl, M., Parlati, F., Söllner, T. H., & Rothman, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81404-x · Cited by 2,481

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417

Mechanisms of intracellular protein transport

Rothman, J. E. (1994) · Nature · doi:10.1038/372055a0 · Cited by 2,267

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

Simonsen, A., Lippe, R., Christoforidis, S., Gaullier, J.-M., Brech, A., Callaghan, J., Toh, B.-H., Murphy, C., Zerial, M., & Stenmark, H. (1998) · Nature · doi:10.1038/28879 · Cited by 1,133

The Rab5 effector EEA1 is a core component of endosome docking

Christoforidis, S., McBride, H. M., Burgoyne, R. D., & Zerial, M. (1999) · Nature · doi:10.1038/17618 · Cited by 854

Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy

Hanson, P. I., Roth, R. A., Morisaki, H., Jahn, R., & Heuser, J. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80512-7 · Cited by 797

The diversity of Rab proteins in vesicle transport

Novick, P., & Zerial, M. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80025-7 · Cited by 757

EEA1, an Early Endosome-Associated Protein.

Mu, F., Callaghan, J. M., Steele‐Mortimer, O., Stenmark, H., Parton, R. G., Campbell, P. L., McCluskey, J., Yeo, J.-P., Tock, E. P. C., & Toh, B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13503 · Cited by 713

The syntaxin family of vesicular transport receptors

Bennett, M. K., Garcia-Arrarás, J., Elferink, L. A., Peterson, K., Fleming, A. M., Hazuka, C. D., & Scheller, R. H. (1993) · Cell · doi:10.1016/0092-8674(93)90466-4 · Cited by 649

The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis

Guo, W., Roth, D., Walch-Solimena, C., & Novick, P. (1999) · The EMBO Journal · doi:10.1093/emboj/18.4.1071 · Cited by 627

Phagocytosis

Naik, U., & Harrison, R. E. (2013) · Colloquium Series on Building Blocks of the Cell Cell Structure and Function · doi:10.4199/c00081ed1v01y201304bbc004 · Cited by 3

In vitro reconstitution of the molecular mechanisms of vesicle tethering and membrane fusion

Perini, E. D. (2012) · Qucosa (Saxon State and University Library Dresden) · Cited by 4

Role of Rabex-5 in the sorting of ubiquitinated cargo at an early stage in the endocytic pathway

Aikawa, Y., & Lee, S. (2013) · Communicative & Integrative Biology · doi:10.4161/cib.24463 · Cited by 3

TbFRP, a novel FYVE-domain containing phosphoinositide-binding Ras-like GTPase from trypanosomes

Adung’a, V. O., & Field, M. C. (2012) · Experimental Parasitology · doi:10.1016/j.exppara.2012.11.007 · Cited by 3

Tracking Intracellular Polymer Localization Via Fluorescence Microscopy

Richardson, S. C. W. (2010) · doi:10.1002/9780470875780.ch10 · Cited by 3

Phase partitioning rules Rab domain formation, growth and identityPreprint

Jiménez, A. J., Divoux, S., Goud, B., & Perez, F. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.17.537227 · Cited by 3

Lipid-Dependent Membrane Remodelling in Protein Trafficking

Chandra, P., & Ktistakis, N. T. (2009) · Springer eBooks · doi:10.1007/978-0-387-93877-6_11 · Cited by 2

Intracellular Membrane Fusion

Xu, D., & Hay, J. (2009) · Springer eBooks · doi:10.1007/978-0-387-93877-6_14 · Cited by 2

Transport of endosomal early antigen 1 in the rat sciatic nerve and location in cultured neurons

Bartlett, S. E., Reynolds, A. J., Weible, M. W., Noakes, P. G., & Hendry, I. A. (2001) · Neuroreport · doi:10.1097/00001756-200102120-00020 · Cited by 2

The Antimicrobial Functions of Macrophages

Flannagan, R. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_6 · Cited by 2

Mycobacterium tuberculosis: Strategies of offense and defense

Розов, С. М., & Дейнеко, Е. В. (2016) · Biology Bulletin Reviews · doi:10.1134/s2079086416040058 · Cited by 2

Intracellular Models ofMycobacterium tuberculosisInfection

Chan, J., Silver, R. F., Kampmann, B., & Wallis, R. S. (2004) · doi:10.1128/9781555817657.ch27 · Cited by 2

Intracellular Trafficking and Signaling: The Role of Endocytic Rab GTPase

Barbieri, M. A., Wainszelbaum, M. J., & Stahl, P. D. (2009) · Springer eBooks · doi:10.1007/978-0-387-93877-6_19 · Cited by 2

Tethering proteins in membrane traffic

Chu, S., & Guo, W. (2004) · Topics in current genetics · doi:10.1007/b98495 · Cited by 2

Tethering Factors

Lupashin, V. V., & Sztul, E. S. (2009) · Springer eBooks · doi:10.1007/978-0-387-93877-6_13 · Cited by 2

Identification of a Rabenosyn-5 like protein and Rab5b in host cell cytosol uptake reveals conservation of endosomal transport in malaria parasitesPreprint

Sabitzki, R., Roßmann, A.-L., Schmitt, M., Flemming, S., Guillén-Samander, A., Behrens, H. M., Jonscher, E., Hoehn, K., Fröhlke, U., & Spielmann, T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.05.535711 · Cited by 2

The diverse functions of syntaxin 13 in endosome-mediated membrane fusion

Zhang, W., Zhang, H., He, T., Li, X., Liu, Y., Han, H., & Wang, J. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141878 · Cited by 1

Rab21 recruits EEA1 and competes with Rab5 for Rabex-5 activation

Yanguas, F., & Progida, C. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1588308 · Cited by 1

Intracellular Transformation of Phagosomes

But, P. G., Murav'ev, R. A., Фомина, В. А., & Vv, R. (2004) · Biology Bulletin · doi:10.1023/b:bibu.0000049728.77980.6f · Cited by 1

Rab-GTPases: Dual Roles in Vesicular Transport and Viral Replication

Hodge, T. W., & Murray, J. L. (2006) · Future Virology · doi:10.2217/17460794.1.6.811 · Cited by 1

Rab Proteins and the Organization of Organelle Membrane Domains

Wieffer, M., McShane, M. P., & Zerial, M. (2014) · Springer eBooks · doi:10.1007/978-3-319-07761-1_2 · Cited by 1

Quantitative analysis of endosome tubulation and microdomain organization mediated by the WASH complex

Derivery, E., & Gautreau, A. M. (2015) · Methods in cell biology · doi:10.1016/bs.mcb.2015.03.025 · Cited by 1

The interaction of the p85 subunit of PI3K with rab proteins

Chamberlain, M. D. (2007) · University Library - University of Saskatchewan (University of Saskatchewan) · Cited by 1

Phagocytosis: Early Events in Particle Recognition and Uptake

Cosı́o, G., & Grinstein, S. (2009) · Wiley eBooks · doi:10.1002/9783527629176.ch3 · Cited by 1

Formation and Maturation

Bradley, R. L., Jr. (2011) · doi:10.1002/9781118192481.ch12 · Cited by 1

Tethering molecules in membrane traffic

Sönnichsen, B. (1999) · PROTOPLASMA · doi:10.1007/bf01415699 · Cited by 1

Human autoantibodies as reagents in biomedical research

Kakinuma, T., Toh, B. H., & Sentry, J. W. (2003) · Modern Rheumatology · doi:10.3109/s101650300002 · Cited by 1

Functions of Vti1a and Vti1b in the Development of the Mouse Nervous System: Evidence from Double Knockout Mice

Kunwar, A. J. (2009) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3634 · Cited by 1

Functions of Rab GTPases in organelle biogenesis

Burd, C. G., & Collins, R. (2004) · Topics in current genetics · doi:10.1007/b97781 · Cited by 1

Identification of a new, Rab14-dependent, endo-lysosomal pathwayPreprint

Trofimenko, E., Homma, Y., Fukuda, M., & Widmann, C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.25.436964 · Cited by 1

Binding and Uptake of Single and Dual-opsonized Target Particles by Macrophages

Naik, U. (2020) · TSpace (University of Toronto) · Cited by 1

Characterisation of red blood cell Phagocytosis and assessment of nanoparticle uptake by Monocytic cells

Jin, Y. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.208148 · Cited by 1

Role of small GTPase Rab32 in CD8+ T cell cross-priming by conventional type 1 Dendritic Cells

Tandon, N. (2020) · theses.fr (ABES) · doi:10.70675/f5b3e394zb14ez46bdz9495z7b854182cc25 · Cited by 1

Rab Domains on Endosomes

Miączyńska, M., & Zerial, M. (2008) · Springer eBooks · doi:10.1007/978-0-387-39951-5_3 · Cited by 1

Selective and Specific Activation of Rab5 during Endocytosis of Receptor Tyrosine Kinases

Jozic, I. (2013) · doi:10.25148/etd.fi13040302

Role of Rab5 in synaptic vesicle recycling

Wucherpfennig, T. (2002) · Kobra (Universitätsbibliothek Kassel)

FYVE Domains in Membrane Trafficking and Cell Signaling

Stefan, C. J., Audhya, A., & Emr, S. D. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50513-1

Elektronenmikroskopische Untersuchung der Veränderungen von chromaffinen Zellen des Nebennierenmarks von Vti1a/Vti1b-Doppel-Knockout-Mäusen

Fleischmann, T. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3774

Regulation of Rab5 GTPase activity during Pseudomonas aeruginosa-macrophage interaction

Mustafi, S. (2013) · doi:10.25148/etd.fi13121213

Investigation of SNARE function in the early endosomal compartment

Bethani, I. (2009) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3220

Endofin is a novel component in EGF/EGFR oncogenic signaling

Toy, W., & Lim, Y. P. (2007) · Clinical Cancer Research

Mechanisms of Endocytic Sorting: A Dissertation

Leonard, D. M. (2006) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/5c82-4606

Interaction between p85 and Rab5 in the presences and absence of phosphorylated PDGFR peptide

Bergman, C. (2012) · University Library - University of Saskatchewan (University of Saskatchewan)

Regulation of endocytosis and secretion by Rab GTPase activating proteins

Haas, A. K. (2008) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.8660

Membrane trafficking in neurons regulated by new syntaxin 13-interacting proteins

Steiner, P. (2004) · PubMed · doi:10.5075/epfl-thesis-3091

Regulation of membrane fusion by Tlg2p & Vps45p through the endosomal system of Saccharomyces cerevisiae

MacDonald, C. (2009) · Enlighten: Theses (The University of Glasgow)

Phagocytosis and signaling in the innate immune system

Gonzalez, E. A. (2012) · University Libraries (University of Maryland)

Functional characterisation of Rab22a and Munc18b, two proteins regulating vesicle transport in mammalian cells

Kauppi, M. (2004) · STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)

Crosstalk between membrane trafficking and cell adhesion:The role of the SNARE protein TI-VAMP in neuronal morphogenesis

Alberts, P. (2004) · Kölner Universitäts PublikationsServer (Universität zu Köln)

IDENTIFICATION AND CHARACTERIZATION OF WASP AND FKBP-LIKE PROTEIN

Viklund, I.-M. (2009) · Figshare

Investigation of early endosomal sorting and budding

Barysch, S. V. (2009) · MPG.PuRe (Max Planck Society)

Investigating Thiol-Dependent Processes in the Phagosome of Macrophages

Balce, D. R. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/26648

The identification and characterisation of Rab4 interacting proteins

Lindsay, A. J. (2001) · Arrow@dit (Dublin Institute of Technology)

Mechanismen der Transzytose von Makromolekülen bei Morbus Crohn: Untersuchungen am Zellmodell T84 und an humanen Kolon-Biopsien

John, L. (2014) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-12366

ADENOVIRUS ENDOCYTOSIS AND ADENOVIRAL GENE TRANSFER IN CARDIOVASCULAR AND DERMATOLOGIC DISEASE MODELS

Oulu, B. (2004)

COMMENTARY Lysosome-endosome fusion and lysosome biogenesis

Luzio, J. P., Rous, B., Bright, N. A., Pryor, P. R., Mullock, B. M., & Piper, R. C. (2000)

Narrowing the Rab GAP: identifying a role for TBC-2 in endosomal trafficking in «Caenorhabditis elegans»

Chotard, L. (2011) · eScholarship@McGill (McGill) · doi:10.82308/51120

Involves Arf6 Inactivation and Changes in Phosphoinositides

Naslavsky, N., Weigert, R., & Donaldson, J. G. (2002)

Apolipoprotein E- und HDL-induzierter Cholesterintransport aus endosomalen Kompartimenten

Beisiegel†, U. (2005)

Adenovirus endocytosis and adenoviral gene transfer in cardiovascular and dermatologic disease models

Rauma‐Pinola, T. (2004)

Rab8 and R-Ras as modulators of cell shape

Furuhjelm, J. (2004) · Työväentutkimus Vuosikirja

Endosomal Maturation Is Controlled By A Rab7 Feedback Loop Concomitant With Vesicular Interactions

Berg-Rolness, H. S. (2012) · NORA - Norwegian Open Research Archives

Cell-cycle-dependent trafficking in the endocytic pathway

Bergeland, T. (2008) · NORA - Norwegian Open Research Archives

Anti‐early endosome antigen 1 autoantibodies were detected in a pemphigus‐like patient but not in the majority of pemphigus diseases

Nishikawa, R., Takahashi, H., Matsuda, M., Imaoka, K., Ogawa, M., Teye, K., Tsuchisaka, A., Koga, H., Komorowski, L., Probst, C., et al. (2016) · Experimental Dermatology · doi:10.1111/exd.12981

CONTROL OF RAB SMALL G-PROTEINS IN YEAST ENDOSOMAL TRAFFIC

Paulsel, A. L. (2013) · ResearchWorks at the University of Washington (University of Washington)

Regulation des intrazellulären Transports durch UNC-50 und die GARP-Komplexes in C. elegans

Luo, L. F. (2010) · doi:10.53846/goediss-3144

von Cholesterin auf die Membranaffinität von Annexin 6 in frühen und späten Endosomen

Zellbiologie, M. (2004)

MINIREVIEW Mosaic Organization of the Endocytic Pathway

Miączyńska, M., & Zerial, M. (2002)

Cancer insights through macropinocytosis: a role for sorting nexins?

Wang, J. T. H., Kerr, M. C., & Teasdale, R. D. (2014)

The influence of cell-free Lactobacillus rhamnosus GG conditioned medium on macrophage functional activity

Nanjundaiah, Y. S. (2016)

The Mechanism of Tubular Recycling Endosome Biogenesis

Xie, S. (2016) · DigitalCommons@UNMC

EXOCYST COMPLEX AND ENDOCYTIC TRAFFICKING IN

Cells, P. E., & Matos, A. O. (2007)

Structural and functional characterization of interactions of myotubularin-related proteins

Gegenschatz‐Schmid, K. (2012) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-007313479

Characterisation of Novel Rab5 Effector Proteins in the Endocytic Pathway

Schnatwinkel, C. (2004) · Qucosa (Saxon State and University Library Dresden)

FYVE Domains in Membrane Trafficking and Cell Signaling

Stefan, C. J., Audhya, A., & Emr, S. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00138-8

The role of phosphatidylinositol 3-kinases in autophagy regulation

Devereaux, K. A. (2014) · doi:10.7916/d8qz2842

Phagosome-Lysosome Fusion Hijack-An Art of Intracellular Pathogens

Rao, R. N., Shrivastava, R., Pradhan, G., Singh, P., & Mukhopadhyay, S. (2017) · Revista de Fomento Social · doi:10.16943/ptinsa/2017/48971

Investigation of Endosomal Recycling of Synaptic Vesicles

Hoopmann, P. (2010) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3146

Functional Analysis of MicroRNAs as Regulators of Membrane Trafficking

Serva, A. (2012) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00013119

Functional analysis of nucleoside diphosphate kinase from Mycobacterium avium subspecies paratuberculosis

Marroushi, Z. (2017) · The Atrium (University of Guelph)

Satnav for cells: Destination membrane fusion

Holt, M. G. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.10.001

The Role of Proteins and Lipids in Organelle Biogenesis in the Secretory Pathway

Martin, T. F. J. (2007) · Springer eBooks · doi:10.1007/0-387-26867-7_3

Role of Rab20 in phagosome maturation and mycobacterial killing

Pei, G. (2013) · Digitale Bibliothek Braunschweig (Verbundzentrale Göttingen (VZG)) · doi:10.24355/dbbs.084-201311211006-0

Eine funktionelle Charakterisierung der frühendosomalen SNARE-Proteine

Geumann, U. (2009) · doi:10.53846/goediss-342

Charakterisierung eines Proteinkomplexes in Säugerzellen, der am Transport zwischen Membrankompartimenten beteiligt ist.

Verrier, S. (2006) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-628

Endocytosis

Watson, H. A., von Zastrow, M., & Wendland, B. (2006) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.200300063 · Cited by 1

Faculty Opinions recommendation of Structural basis for Rab GTPase activation by VPS9 domain exchange factors.

Smythe, E. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1083829.536767

Characterisation of the Early Endosomal SNARE Complex

Zwilling, D. (2005) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3218

A quantitative analysis of the molecular organization of dendritic spines from hippocampal neurons

Helm, M. S. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7592

Faculty Opinions recommendation of An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway.

Keshet, L. (2005) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1027488.342158

Faculty Opinions recommendation of A non-linear system patterns Rab5 GTPase on the membrane.

Chang, C. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738105261.793575587

Regulation of lysosome biogenesis by phosphoinositides and phagocytosis

Choy, C. (2021) · doi:10.32920/ryerson.14648823.v1

Faculty Opinions recommendation of A non-linear system patterns Rab5 GTPase on the membrane.

Goryachev, A. B. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738105261.793575468

The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells

Chintaluri, K. (2021) · doi:10.32920/ryerson.14661819.v1

FYVE Domain

Kutateladze, T. G., & Overduin, M. (2004) · Encyclopedia of Inorganic and Bioinorganic Chemistry · doi:10.1002/9781119951438.eibc0490

FYVE Domain

Kutateladze, T. G., & Overduin, M. (2004) · Handbook of Metalloproteins · doi:10.1002/0470028637.met023

R ab GTP ases

Quellhorst, G. J., & Wessling‐Resnick, M. (2002) · Wiley Encyclopedia of Molecular Medicine · doi:10.1002/0471203076.emm0980

Endosomes

Galvez, T., & Zerial, M. (2011) · Wiley eBooks · doi:10.1002/9781118015759.ch9

Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms

Poirier, V., & Av‐Gay, Y. (2016) · ASM Press eBooks · doi:10.1128/9781555819286.ch24

Endosome Fusion

Brandhorst, D., & Jahn, R. (2008) · Springer eBooks · doi:10.1007/978-0-387-39951-5_5

The Rab5 Effector EEA1 Interacts Directly with Syntaxin-6

Simonsen, A., Gaullier, J., D’Arrigo, A., & Stenmark, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.28857 · Cited by 248

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

Ohya, T., Miączyńska, M., Coskun, Ü., Lommer, B. S., Runge, A., Drechsel, D. N., Kalaidzidis, Y. L., & Zerial, M. (2009) · Nature · doi:10.1038/nature08107 · Cited by 235

The Rab5 effector EEA1 is a core component of endosome docking

Christoforidis, S., McBride, H. M., Burgoyne, R. D., & Zerial, M. (1999) · Nature · doi:10.1038/17618 · Cited by 854

In brief

(2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2722

An endosomal tether undergoes an entropic collapse to bring vesicles together

Murray, D. H., Jahnel, M., Lauer, J. L., Avellaneda, M. J., Brouilly, N., Cezanne, A., Morales-Navarrete, H. A., Perini, E. D., Ferguson, C., Lupas, A. N., et al. (2016) · Nature · doi:10.1038/nature19326 · Cited by 161