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Protein Sorting upon Exit from the Endoplasmic Reticulum
Open accessAbstract
It is currently thought that all secretory proteins travel together to the Golgi apparatus where they are sorted to different destinations. However, the specific requirements for transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi apparatus in yeast could be explained if protein sorting occurs earlier in the pathway. Using an in vitro assay that reconstitutes a single round of budding from the endoplasmic reticulum, we found that GPI-anchored proteins and other secretory proteins exit the endoplasmic reticulum in distinct vesicles. Therefore, GPI-anchored proteins are sorted from other proteins, in particular other plasma membrane proteins, at an early stage of the secretory pathway. These results have wide implications for the mechanism of protein exit from the endoplasmic reticulum.
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Cited by
BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI
Lee, M. C. S., Miller, E. A., Goldberg, J., Orci, L., & Schekman, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.105307 · Cited by 813
Roles of lipid rafts in membrane transport
Ikonen, E. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00238-6 · Cited by 629
Natale, P., Brüser, T., & Driessen, A. J. M. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.015 · Cited by 542
Mayor, S., & Riezman, H. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1309 · Cited by 428
Self-citationPeter, O., & Menon, A. K. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700002-jlr200 · Cited by 403
Metadata
- Authors
- Muñiz, M., Morsomme, P., & Riezman, H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 104
- Issue
- 2
- Pages
- 313-320
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2134403233
- Cited by
- 251
- References
- 0
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Muñiz, M., Morsomme, P., & Riezman, H. (2001). Protein Sorting upon Exit from the Endoplasmic Reticulum. Cell. https://doi.org/10.1016/s0092-8674(01)00215-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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