The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.
Thematic review series: Lipid Posttranslational Modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids
Open accessAbstract
Glycosylphosphatidylinositol (GPI) anchoring of cell surface proteins is the most complex and metabolically expensive of the lipid posttranslational modifications described to date. The GPI anchor is synthesized via a membrane-bound multistep pathway in the endoplasmic reticulum (ER) requiring >20 gene products. The pathway is initiated on the cytoplasmic side of the ER and completed in the ER lumen, necessitating flipping of a glycolipid intermediate across the membrane. The completed GPI anchor is attached to proteins that have been translocated across the ER membrane and that display a GPI signal anchor sequence at the C terminus. GPI proteins transit the secretory pathway to the cell surface; in yeast, many become covalently attached to the cell wall. Genes encoding proteins involved in all but one of the predicted steps in the assembly of the GPI precursor glycolipid and its transfer to protein in mammals and yeast have now been identified. Most of these genes encode polytopic membrane proteins, some of which are organized in complexes. The steps in GPI assembly, and the enzymes that carry them out, are highly conserved. GPI biosynthesis is essential for viability in yeast and for embryonic development in mammals. In this review, we describe the biosynthesis of mammalian and yeast GPIs, their transfer to protein, and their subsequent processing.
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Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES
Brown, D. A., & London, E. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.111 · Cited by 2,948
Roles of N-Linked Glycans in the Endoplasmic Reticulum
Helenius, A., & Aebi, M. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073752 · Cited by 2,037
An Evolving Hierarchical Family Classification for Glycosyltransferases
Coutinho, P. M., Deleury, E., Davies, G. J., & Henrissat, B. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00307-3 · Cited by 1,211
Palmitoylation: policing protein stability and traffic
Linder, M. E., & Deschenes, R. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2084 · Cited by 1,185
N-Linked Glycosylation in Campylobacter jejuni and Its Functional Transfer into E. coli
Wacker, M., Linton, D., Hitchen, P. G., Nita-Lazar, M., Haslam, S. M., North, S. J., Panico, M., Morris, H. R., Dell, A., Wren, B. W., et al. (2002) · Science · doi:10.1126/science.298.5599.1790 · Cited by 777
Ferguson, M. A. J., Homans, S. W., Dwek, R. A., & Rademacher, T. W. (1988) · Science · doi:10.1126/science.3340856 · Cited by 705
Architecture of the Yeast Cell Wall
Kollár, R., Reinhold, B. B., Petráková, E., Yeh, H. J. C., Ashwell, G., Drgonová, J., Kapteyn, J. C., Klis, F. M., & Cabib, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17762 · Cited by 644
Ferguson, M. A. J. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.17.2799 · Cited by 632
An evolving view of the eukaryotic oligosaccharyltransferase
Kelleher, D. J., & Gilmore, R. (2006) · Glycobiology · doi:10.1093/glycob/cwj066 · Cited by 528
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Glycosylation in health and disease
Reily, C., Stewart, T. J., Renfrow, M. B., & Novak, J. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0129-4 · Cited by 2,075
Protein Glycosylation in Cancer
Stowell, S. R., Ju, T., & Cummings, R. D. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040438 · Cited by 873
The repertoire of glycan determinants in the human glycome
Cummings, R. D. (2009) · Molecular BioSystems · doi:10.1039/b907931a · Cited by 487
Architecture and Biosynthesis of the Saccharomyces cerevisiae Cell Wall
Orlean, P. (2012) · Genetics · doi:10.1534/genetics.112.144485 · Cited by 478
Shaw, K. J., & Ibrahim, A. S. (2020) · Journal of Fungi · doi:10.3390/jof6040239 · Cited by 229
Metadata
- Authors
- Peter, O., & Menon, A. K.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 48
- Issue
- 5
- Pages
- 993-1011
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1984666864
- Cited by
- 403
- References
- 167
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Peter, O., & Menon, A. K. (2007). Thematic review series: Lipid Posttranslational Modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids. Journal of Lipid Research. https://doi.org/10.1194/jlr.r700002-jlr200
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