The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Error-Prone DNA Polymerases
Open accessAbstract
Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.
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“Crystal structures (Refs.15-22 and references therein) reveal that polymerase binding to DNA strongly reshapes the primertemplate, e.g. the backbone at the templating base can be bent by 90°.”
From DNA Replication Fidelity (2004) · cites this paper as [20]
In the citing paper
“These ideas are supported by structural information (20, 21, 26 -28) and by a report (29) that the insertion fidelity of yeast Pol is severely impaired with difluorotoluene, a nonpolar isosteric analog of thymine that is unable to form Watson-Crick hydrogen bonds with adenine.”
From DNA Replication Fidelity (2004) · cites this paper as [20]
In the citing paper
“Moreover, certain Y family polymerases are suggested to be in a closed conformation without dNTP (Refs.20 and 21 but also see comments in Ref. 28), yet kinetic data (40) have emphasized the importance of a dNTP-induced conformational change preceding chemistry to the fidelity of Pol .”
From DNA Replication Fidelity (2004) · cites this paper as [20]
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Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Self-citationBootsma, D., & Hoeijmakers, J. H. J. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81408-9 · Cited by 2,285
Kunkel, T. A., & Bebenek, K. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.497 · Cited by 1,003
The Y-Family of DNA Polymerases
Ohmori, H., Friedberg, E. C., Fuchs, R. P., Goodman, M. F., Hanaoka, F., Hinkle, D. C., Kunkel, T. A., Lawrence, C. W., Livneh, Z., Nohmi, T., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00278-7 · Cited by 882
Self-citationExcision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair
Matsumoto, Y., & Kim, K. (1995) · Science · doi:10.1126/science.7624801 · Cited by 683
Crystal Structure of a Y-Family DNA Polymerase in Action
Ling, H., Boudsocq, F., Woodgate, R., & Yang, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00515-3 · Cited by 610
Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis
Tang, M., Pham, P., Shen, X., Taylor, J.-S., O'Donnell, M., Woodgate, R., & Goodman, M. F. (2000) · Nature · doi:10.1038/35010020 · Cited by 443
Low fidelity DNA synthesis by human DNA polymerase-η
Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., & Kunkel, T. A. (2000) · Nature · doi:10.1038/35010014 · Cited by 372
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η
Haracska, L., Yu, S.-L., Johnson, R. E., Prakash, L., & Prakash, S. (2000) · Nature Genetics · doi:10.1038/78169 · Cited by 356
Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η
Trincão, J., Johnson, R. E., Escalante, C. R., Prakash, S., Prakash, L., & Aggarwal, A. K. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00306-9 · Cited by 348
Research works printed but not linked: 2
- Masutani, 2000, Cold Spring Harb, Symp. Quant. Biol., 65, 61
- Wang, 2001, Mutation Res, DNA Rep., 486, 59
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Capellá, G., Balart, J., & Peinado, M. A. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-470-4_13 · Cited by 1
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(2014) · ASM Press eBooks · doi:10.1128/9781555816704.ch15 · Cited by 1
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Koonin, E. V. (2006) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0006119
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TARTU ÜLIKOOL BIOLOOGIA-GEOGRAAFIA TEADUSKOND MOLEKULAAR- JA RAKUBIOLOOGIA INSTITUUT
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Self-citationSignal Transduction in the Escherichia coli SOS Response
Beuning, P. J., & Walker, G. C. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50661-6
Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ
Antczak (2017) · Digital Repository Service (Northeastern University) · doi:10.17760/d20260514
Luo, B., Edge, A. K., Tölg, C., Turley, E. A., Dean, C. B., Hill, K. A., & Kulperger, R. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204156
Structural insights into DNA replication and lesion bypass by Y family DNA polymerases
Kirouac, K. N. (2010) · Scholarship@Western (Western University)
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. E. (2014) · ASM Press eBooks · doi:10.1128/9781555816704.ch3
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Goedecke, W. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.62996-4
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Caractérisation fonctionnelle de la tolérance aux endommagements de l’ADN des embryons précoces
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Kusumoto-Matsuo, R., Masuda, Y., Kanao, R., Iwai, S., & Masutani, C. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113555
Metadata
- Authors
- Friedberg, E. C., Fischhaber, P. L., & Kisker, C.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- State University of New York (US)
- Corresponding author
- Friedberg, Errol C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 107
- Issue
- 1
- Pages
- 9-12
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1966195927
- Cited by
- 130
- References
- 16
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- error-prone DNA polymerases, DNA polymerase fidelity, translesion synthesis, DNA damage, polymerase structure, DNA replication
- MeSH terms
- Amino Acid Sequence, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, Humans, Models, Molecular, Molecular Sequence Data, Mutation, Protein Conformation, Sequence Alignment, Protein Structure, Tertiary, Crystallography, X-Ray
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