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XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
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Citations
Cites
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
Ye, J., Rawson, R. B., Komuro, R., Chen, X., Davé, U. P., Prywes, R., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00133-7 · Cited by 1,871
Yoshida, H., Okada, T., Haze, K., Yanagi, H., Yura, T., Negishi, M., & Mori, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6755-6767.2000 · Cited by 934
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Carvalho-Gontijo, R., Han, C., Zhang, L., Zhang, V., Hosseini, M., Mekeel, K., Schnabl, B., Loomba, R., Karin, M., Brenner, D. A., et al. (2022) · Seminars in Liver Disease · doi:10.1055/s-0042-1755316 · Cited by 23
Nicolas Nicolaz, C., Zhadobov, M., Desmots, F., Sauleau, R., Thouroude, D., Michel, D., & Le Drean, Y. (2009) · Cell Biology and Toxicology · doi:10.1007/s10565-008-9101-y · Cited by 24
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Hu, Y., Yang, W., Xie, L., Liu, T., Liu, H., & Liu, B. (2020) · Pulmonary Circulation · doi:10.1177/2045894019900121 · Cited by 21
Bartoszewska, S., Króliczewski, J., Crossman, D. K., Pogorzelska, A., Bagiński, M., Collawn, J. F., & Bartoszewski, R. (2021) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-021-00255-y · Cited by 17
Stefan, C. P., & Cunningham, K. W. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.508705 · Cited by 15
White Matter in Crisis: Oligodendrocytes and the Pathophysiology of Multiple Sclerosis
García-Domínguez, M. (2025) · Cells · doi:10.3390/cells14181408 · Cited by 13
“Spliced XBP1 mRNA functions as a transcriptional activator that upregulates several genes that encode ER chaperones, like BiP/GRP78 and GRP94, as well as some components of the ERAD pathway, thereby contributing to the restoration of ER protein-folding homeostasis [174].”
5-Azacytidine engages an IRE1α-EGFR-ERK1/2 signaling pathway that stabilizes the LDL receptor mRNA
Mnasri, N., Mamarbachi, M., Allen, B. G., & Mayer, G. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2017.11.010 · Cited by 12
Williams, A. B., Heider, F., Messling, J.-E., Rieckher, M., Bloch, W., & Schumacher, B. (2019) · Genetics · doi:10.1534/genetics.119.302422 · Cited by 10
Dabsan, S., Zur, G., Abu-Freha, N., Sofer, S., Grossman-Haham, I., Gilad, A., & Igbaria, A. (2025) · eLife · doi:10.7554/elife.102658 · Cited by 10
Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms
Bjune, K., Wierød, L., & Naderi, S. (2019) · PLOS ONE · doi:10.1371/journal.pone.0218537 · Cited by 8
Ranjan, K. (2020) · Gastrointestinal Disorders · doi:10.3390/gidisord2030024 · Cited by 6
Structural dynamics of IRE1 and its interaction with unfolded peptides
Spinetti, E., Ścibisz, G., Karagöz, G. E., & Covino, R. (2026) · eLife · doi:10.7554/elife.106716
Metadata
- Authors
- Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., & Mori, K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 107
- Issue
- 7
- Pages
- 881-891
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1970090817
- Cited by
- 4,039
- References
- 2
- FWCI
- 21.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
