The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Crystal Structure of a Hedgehog Autoprocessing Domain: Homology between Hedgehog and Self-Splicing Proteins
Open accessAbstract
The approximately 25 kDa carboxy-terminal domain of Drosophila Hedgehog protein (Hh-C) possesses an autoprocessing activity that results in an intramolecular cleavage of full-length Hedgehog protein and covalent attachment of a cholesterol moiety to the newly generated amino-terminal fragment. We have identified a 17 kDa fragment of Hh-C (Hh-C17) active in the initiation of autoprocessing and report here its crystal structure. The Hh-C17 structure comprises two homologous subdomains that appear to have arisen from tandem duplication of a primordial gene. Residues in the Hh-C17 active site have been identified, and their role in Hedgehog autoprocessing probed by site-directed mutagenesis. Aspects of sequence, structure, and reaction mechanism are conserved between Hh-C17 and the self-splicing regions of inteins, permitting reconstruction of a plausible evolutionary history of Hh-C and the inteins.
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Cites
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Collaborative Computational Project, N. 4. (1994) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444994003112 · Cited by 17,270
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Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
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Self-citationDetermination of Macromolecular Structures from Anomalous Diffraction of Synchrotron Radiation
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Cited by
Inteins: nature's gift to protein chemists
Shah, N. H., & Muir, T. W. (2014) · Chem. Sci. · doi:10.1039/c3sc52951g · Cited by 404
Nature's recipe for splitting inteins
Aranko, A. S., Wlodawer, A., & Iwai, H. (2014) · Protein Engineering Design and Selection · doi:10.1093/protein/gzu028 · Cited by 116
Metadata
- Authors
- Hall, T. M. T., Porter, J. A., Young, K. E., Koonin, E. V., Beachy, P. A., & Leahy, D. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 91
- Issue
- 1
- Pages
- 85-97
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1990210405
- Cited by
- 275
- References
- 42
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hall, T. M. T., Porter, J. A., Young, K. E., Koonin, E. V., Beachy, P. A., & Leahy, D. J. (1997). Crystal Structure of a Hedgehog Autoprocessing Domain: Homology between Hedgehog and Self-Splicing Proteins. Cell. https://doi.org/10.1016/s0092-8674(01)80011-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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