The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
The AP-3 Adaptor Complex Is Essential for Cargo-Selective Transport to the Yeast Vacuole
Open accessAbstract
Three distinct adaptor protein (AP) complexes involved in protein trafficking have been identified. AP-1 and AP-2 mediate protein sorting at the trans-Golgi network and plasma membrane, respectively, whereas the function of AP-3 has not been defined. A screen for factors specifically involved in transport of alkaline phosphatase (ALP) from the Golgi to the vacuole/lysosome has identified Ap16p and Ap15p of the yeast AP-3 complex. Deletion of each of the four AP-3 subunits results in selective mislocalization of ALP and the vacuolar t-SNARE, Vam3p (but not CPS and CPY), while deletion of AP-1 and AP-2 subunits has no effect on vacuolar protein delivery. This study, therefore, provides evidence that the AP-3 complex functions in cargo-selective protein transport from the Golgi to the vacuole/lysosome.
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Metadata
- Authors
- Cowles, C. R., Odorizzi, G., Payne, G. S., & Emr, S. D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 91
- Issue
- 1
- Pages
- 109-118
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2072070715
- Cited by
- 428
- References
- 48
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cowles, C. R., Odorizzi, G., Payne, G. S., & Emr, S. D. (1997). The AP-3 Adaptor Complex Is Essential for Cargo-Selective Transport to the Yeast Vacuole. Cell. https://doi.org/10.1016/s0092-8674(01)80013-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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