The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal
Open accessAbstract
Efficient engulfment of the intact cell corpse is a critical end point of apoptosis, required to prevent secondary necrosis and inflammation. The presentation of "eat-me" signals on the dying cell is an important part of this process of recognition and engulfment by professional phagocytes. Here, we present evidence that apoptotic cells secrete chemotactic factor(s) that stimulate the attraction of monocytic cells and primary macrophages. The activation of caspase-3 in the apoptotic cell was found to be required for the release of this chemotactic factor(s). The putative chemoattractant was identified as the phospholipid, lysophosphatidylcholine. Further analysis showed that lysophosphatidylcholine was released from apoptotic cells due to the caspase-3 mediated activation of the calcium-independent phospholipase A(2). These data suggest that in addition to eat-me signals, apoptotic cells display attraction signals to ensure the efficient removal of apoptotic cells and prevent postapoptotic necrosis.
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“However, autoimmunity has been observed in mice in which phagocytes lack the G-protein coupled receptor G2A41, which is required for the response to lysophosphatidylcholine 42”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [41]
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Cites
3 retracted
Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A
Kabarowski, J. H. S., Zhu, K., Le, L. Q., Witte, O. N., & Xu, Y. (2001) · Science · doi:10.1126/science.1061781 · Cited by 332
Self-citationRetractedSphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1
Xu, Y., Zhu, K., Hong, G., Wu, W., Baudhuin, L. M., Xiao, Y.-J., & Damron, D. S. (2000) · Nature Cell Biology · doi:10.1038/35010529 · Cited by 289
Self-citationRetractedZhu, K., Baudhuin, L. M., Hong, G., Williams, F. S., Cristina, K. L., Kabarowski, J. H. S., Witte, O. N., & Xu, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008057200 · Cited by 242
Self-citationRetractedFadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 1×
“Conversely, by the expression of anti-inflammatory cytokines such caspases might directly cleave the putative inhibitor and as transforming growth factor- (Fadok et al., 1998). thereby release iPLA2.”
BackgroundCaspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis
Jänicke, R. U., Sprengart, M. L., Wati, M. R., & Porter, A. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9357 · Cited by 1,955
Natural adjuvants: Endogenous activators of dendritic cells
Gallucci, S., Lolkema, M. P., & Matzinger, P. (1999) · Nature Medicine · doi:10.1038/15200 · Cited by 1,601
Corpse clearance defines the meaning of cell death
Savill, J., & Fadok, V. A. (2000) · Nature · doi:10.1038/35037722 · Cited by 1,572
A receptor for phosphatidylserine-specific clearance of apoptotic cells
Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491
Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
Sebbagh, M., Renvoizé, C., Hamelin, J., Riché, N., Bertoglio, J., & Bréard, J. (2001) · Nature Cell Biology · doi:10.1038/35070019 · Cited by 915
Cited by
Sorted by citations
Apoptosis: controlled demolition at the cellular level
Taylor, R. C., Cullen, S. P., & Martin, S. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2312 · Cited by 2,708
Molecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382
Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells
Fink, S. L., & Cookson, B. T. (2005) · Infection and Immunity · doi:10.1128/iai.73.4.1907-1916.2005 · Cited by 2,270
Programmed Cell Death in Animal Development and Disease
Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654
Metadata
- Authors
- Lauber, K., Bohn, E., Kröber, S. M., Xiao, Y.-J., Blumenthal, S. G., Lindemann, R. K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S., Xu, Y., Autenrieth, I. B., Schulze-Osthoff, K., Belka, C., Stuhler, G., & Wesselborg, S.
- Affiliations
- University of Tübingen (DE)
- Cleveland Clinic (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Wesselborg, Sebastian
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 113
- Issue
- 6
- Pages
- 717-730
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2159330173
- Cited by
- 967
- References
- 35
- Citations by year
- 2026: 31 · 2025: 31 · 2024: 42 · 2023: 41 · 2022: 50 · 2021: 40 · 2020: 32 · 2019: 31 · 2018: 43 · 2017: 33 · 2016: 37 · 2015: 39 · 2014: 44 · 2013: 43 · 2012: 36
- FWCI
- 15.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3699 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- efferocytosis, caspase-3, lysophosphatidylcholine, phagocyte migration, macrophages, monocytic cells, calcium-independent phospholipase A2, eat-me signals, secondary necrosis, inflammation
- MeSH terms
- Animals, Chemotaxis, Enzyme Inhibitors, Eukaryotic Cells, Humans, Inflammation, Lysophosphatidylcholines, Phagocytes, Phagocytosis, Phospholipases A, Protein Synthesis Inhibitors, Signal Transduction, Ankyrin Repeat, Apoptosis, HT29 Cells, COS Cells, Caspases, Cell Surface Extensions, Lipid Metabolism, Mice, Caspase 3
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