Programmed Cell Death in Animal Development and Disease
Open accessAbstract
Programmed cell death (PCD) plays a fundamental role in animal development and tissue homeostasis. Abnormal regulation of this process is associated with a wide variety of human diseases, including immunological and developmental disorders, neurodegeneration, and cancer. Here, we provide a brief historical overview of the field and reflect on the regulation, roles, and modes of PCD during animal development. We also discuss the function and regulation of apoptotic proteins, including caspases, the key executioners of apoptosis, and review the nonlethal functions of these proteins in diverse developmental processes, such as cell differentiation and tissue remodeling. Finally, we explore a growing body of work about the connections between apoptosis, stem cells, and cancer, focusing on how apoptotic cells release a variety of signals to communicate with their cellular environment, including factors that promote cell division, tissue regeneration, and wound healing.
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RCD can occur in the absence of any exogenous environmental perturbation, operating as a built-in effector of physiological programs for development or tissue turnover.
“On the one hand, RCD can occur in the absence of any exogenous environmental perturbation, hence operating as a built-in effector of physiological programs for development or tissue turnover [6, 18].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [6]
Waves of cellular senescence followed by RCD contribute to developmental embryogenesis (dispensable) and to adult tissue repair/regeneration, immunity, stem cell preservation, and oncosuppression.
“Waves of cellular senescence (followed by RCD) appear to contribute to developmental embryogenesis (although in a dispensable manner) [6, 946, 947] as well as to multiple pathophysiological processes in the adult, including tissue repair and regeneration, immunity, preservation of the stem cell compartment, and oncosuppression [948–957].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [6]
Phagocytes might actively induce cell death to shape tissues and form functional circuits.
“Alternatively, these phagocytes may promote cell death to sculpt tissue structures and create functional circuits (Fuchs and Steller, 2011).”
From Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing (2019) · cites this paper as Fuchs and Steller, 2011
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- Authors
- Fuchs, Y., & Steller, H.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Steller, Hermann
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 147
- Issue
- 4
- Pages
- 742-758
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4511103
- OpenAlex
- W2042141743
- Cited by
- 1,915
- References
- 211
- Citations by year
- 2026: 79 · 2025: 122 · 2024: 188 · 2023: 166 · 2022: 153 · 2021: 204 · 2020: 146 · 2019: 129 · 2018: 135 · 2017: 106 · 2016: 129 · 2015: 123 · 2014: 91 · 2013: 85 · 2012: 55
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences (R01GM060124)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- programmed cell death, apoptosis, animal development, tissue homeostasis, caspases, cell differentiation, tissue remodeling, stem cells, cancer, neurodegeneration, immune disorders, wound healing, tissue regeneration
- MeSH terms
- Animals, Humans, Morphogenesis, Neoplasms, Stem Cells, Apoptosis, Neurodegenerative Diseases, Embryonic Development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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