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dMyc Transforms Cells into Super-Competitors
Open accessAbstract
Overexpression of myc protooncogenes has been implicated in the genesis of many human tumors. Myc proteins seem to regulate diverse biological processes, but their role in tumorigenesis remains enigmatic. Here we use Drosophila imaginal discs to mimic situations in which cells with unequal levels of Myc protein are apposed and show that this invariably elicits a win/lose situation reminiscent of cell competition; cells with lower levels of dMyc are eliminated by apoptosis whereas cells with higher levels of dMyc over-proliferate. We find that this competitive behavior correlates with, and can be corrected by, the activation of the BMP/Dpp survival signaling pathway. Hence the heritable increase in dMyc levels causes cells to behave as "super-competitors" and reveals a novel mode of clonal expansion that causes, but also relies on, the killing of surrounding cells.
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Cited by
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Farhadifar, R., Röper, J.-C., Aigouy, B., Eaton, S., & Jülicher, F. (2007) · Current Biology · doi:10.1016/j.cub.2007.11.049 · Cited by 1,253
Dang, C. V., O’Donnell, K. A., Zeller, K. I., Nguyen, T., Osthus, R. C., & Li, F. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.014 · Cited by 1,188
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Berry, D. L., & Baehrecke, E. H. (2007) · Cell · doi:10.1016/j.cell.2007.10.048 · Cited by 602
Goriely, A., & Wilkie, A. O. M. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.12.017 · Cited by 365
Metadata
- Authors
- Moreno, E., & Basler, K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 117
- Issue
- 1
- Pages
- 117-129
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2050533433
- Cited by
- 595
- References
- 0
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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