The c-Myc target gene network

Emergence of Scaling in Random Networks

Barabási, A.-L., & Albert, R. (1999) · Science · doi:10.1126/science.286.5439.509 · Cited by 36,135 · see citing works

Error and attack tolerance of complex networks

Albert, R., Jeong, H., & Barabási, A.-L. (2000) · Nature · doi:10.1038/35019019 · Cited by 7,534 · see citing works

Error and attack tolerance of complex networksPreprint

Albert, R., Jeong, H., & Barabási, A.-Ĺ. (2000) · Cited by 6,554 · see citing works

Network motifs in the transcriptional regulation network of Escherichia coli

Shen-Orr, S. S., Milo, R., Mangan, S., & Alon, U. S. (2002) · Nature Genetics · doi:10.1038/ng881 · Cited by 2,970 · see citing works

c-Myc-regulated microRNAs modulate E2F1 expression

O’Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V., & Mendell, J. T. (2005) · Nature · doi:10.1038/nature03677 · Cited by 2,812 · see citing works

A Gene-Coexpression Network for Global Discovery of Conserved Genetic Modules

Stuart, J. M., Segal, E., Koller, D., & Kim, S. K. (2003) · Science · doi:10.1126/science.1087447 · Cited by 2,235 · see citing works

Structure and function of the feed-forward loop network motif

Mangan, S., & Alon, U. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2133841100 · Cited by 1,827 · see citing works

c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

Dang, C. V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.1 · Cited by 1,707 · see citing works

A genomic regulatory network for development

Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C.-H., Minokawa, T., Amore, G., Hinman, V., Arenas-Mena, C., et al. (2002) · Science · doi:10.1126/science.1069883 · Cited by 1,567 · see citing works

Reverse engineering of regulatory networks in human B cells

Basso, K., Margolin, A. A., Stolovitzky, G. A., Klein, U., Dalla‐Favera, R., & Califano, A. (2005) · Nature Genetics · doi:10.1038/ng1532 · Cited by 1,406 · see citing works

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

Grandori, C., Cowley, S. M., James, L. P., & Eisenman, R. N. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.653 · Cited by 1,333 · see citing works

c-MYC: more than just a matter of life and death

Pelengaris, S., Khan, M., & Evan, G. I. (2002) · Nature reviews. Cancer · doi:10.1038/nrc904 · Cited by 1,172 · see citing works

MYC oncogenes and human neoplastic disease

Nesbit, C. E., Tersak, J. M., & Prochownik, E. V. (1999) · Oncogene · doi:10.1038/sj.onc.1202746 · Cited by 1,163 · see citing works

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

Cawley, S., Bekiranov, S., Ng, H. H., Kapranov, P., Sekinger, E. A., Kampa, D., Piccolboni, A., Sementchenko, V., Cheng, J., Williams, A. J., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00127-8 · Cited by 1,095 · see citing works

Genomic targets of the human c-Myc proteinPreprint

Fernandez, P. C., Frank, S. R., Wang, L., Schroeder, M., Liu, S., Greene, J. R., Cocito, A., & Amati, B. B. (2003) · Genes & Development · doi:10.1101/gad.1067003 · Cited by 963 · see citing works

Reversible tumorigenesis by MYC in hematopoietic lineages.

Felsher, D., & Bishop, J. (1999) · Molecules and Cells · doi:10.1016/s1097-2765(00)80367-6 · Cited by 917 · see citing works

Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc

Osthus, R. C., Shim, H., Kim, S., Li, Q., Reddy, R., Mukherjee, M., Xu, Y., Wonsey, D. R., Lee, L. A., & Dang, C. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000023200 · Cited by 876 · see citing works

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

Lau, L. F., & Nathans, D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1182 · Cited by 856 · see citing works

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Alland, L., Muhle, R., Hou, H., Potes, J., Chin, L., Schreiber‐Agus, N., & DePinho, R. A. (1997) · Nature · doi:10.1038/387049a0 · Cited by 841 · see citing works

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823 · see citing works

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

Coller, H. A., Grandori, C., Tamayo, P., Colbert, T., Lander, E. S., Eisenman, R. N., & Golub, T. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3260 · Cited by 823 · see citing works

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

Yeh, E., Cunningham, M., Arnold, H., Chasse, D., Monteith, T., Ivaldi, G., Hahn, W. C., Stukenberg, P. T., Shenolikar, S., Uchida, T., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1110 · Cited by 791 · see citing works

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

Bello-Fernández, C., Packham, G., & Cleveland, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7804 · Cited by 783 · see citing works

Structure and evolution of transcriptional regulatory networks

Babu, M. M., Luscombe, N. M., Aravind, L., Gerstein, M., & Teichmann, S. A. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.05.004 · Cited by 764 · see citing works

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

McMahon, S. B., Van Buskirk, H. A., Dugan, K. A., Copeland, T. D., & Cole, M. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81479-8 · Cited by 693 · see citing works

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

Seoane, J., Le, H.-V., & Massagué, J. (2002) · Nature · doi:10.1038/nature01119 · Cited by 683 · see citing works

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

Grandori, C., Gomez-Roman, N., Felton-Edkins, Z. A., Ngouenet, C., Galloway, D. A., Eisenman, R. N., & White, R. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1224 · Cited by 659 · see citing works

Mouse development and cell proliferation in the absence of D-cyclins

Kozar, K., Ciemerych, M. A., Rebel, V. I., Shigematsu, H., Zagozdzon, A., Sicinska, E., Geng, Y., Yu, Q., Bhattacharya, S., Bronson, R. T., et al. (2004) · Cell · doi:10.1016/j.cell.2004.07.025 · Cited by 647 · see citing works

Drosophila Myc Regulates Organ Size by Inducing Cell Competition

de la Cova, C., Abril, M., Bellosta, P., Gallant, P., & Johnston, L. A. (2004) · Cell · doi:10.1016/s0092-8674(04)00214-4 · Cited by 610 · see citing works

dMyc Transforms Cells into Super-Competitors

Moreno, E., & Basler, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00262-4 · Cited by 597 · see citing works

Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

Ayer, D. E., Lawrence, Q., & Eisenman, R. N. (1995) · Cell · doi:10.1016/0092-8674(95)90355-0 · Cited by 587 · see citing works

Repression of p15INK4b expression by Myc through association with Miz-1

Staller, P., Peukert, K., Kiermaier, A. C., Seoane, J., Lukas, J., Karsunky, H., Möröy, T., Bártek, J., Massagué, J., Hänel, F., et al. (2001) · Nature Cell Biology · doi:10.1038/35070076 · Cited by 574 · see citing works

Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: Variations in yield, growth, and differentiation

Phinney, D. G., Kopen, G. C., Isaacson, R. L., & Prockop, D. J. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990315)72:4 · Cited by 545 · see citing works

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

Li, Z., Calcar, S. V., Qu, C., Cavenee, W. K., Zhang, M. Q., & Ren, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332764100 · Cited by 524 · see citing works

c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progressionPreprint

Baudino, T. A., McKay, C., Pendeville, H., Nilsson, J. A., Maclean, K. H., White, E. L., Davis, A. C., Ihle, J. N., & Cleveland, J. L. (2002) · Genes & Development · doi:10.1101/gad.1024602 · Cited by 516 · see citing works

Skp2 Regulates Myc Protein Stability and Activity

Kim, S. Y., Herbst, A., Tworkowski, K. A., Salghetti, S. E., & Tansey, W. P. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00173-4 · Cited by 508 · see citing works

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

Seoane, J., Pouponnot, C., Staller, P., Schader, M. B., Eilers, M., & Massagué, J. (2001) · Nature Cell Biology · doi:10.1038/35070086 · Cited by 489 · see citing works

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Zeller, K. I., Jegga, A. G., Aronow, B. J., O’Donnell, K. A., & Dang, C. V. (2003) · Genome biology · doi:10.1186/gb-2003-4-10-r69 · Cited by 483 · see citing works

Translocations involving c-myc and c-myc function

Boxer, L. M., & Dang, C. V. (2001) · Oncogene · doi:10.1038/sj.onc.1204595 · Cited by 477 · see citing works

Osprey: a network visualization system

Breitkreutz, B., Stark, C., & Tyers, M. (2003) · Genome biology · doi:10.1186/gb-2003-4-3-r22 · Cited by 472 · see citing works

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

Arabi, A., Wu, S., Ridderstråle, K., Bierhoff, H., Shiue, C.-N., Fátyol, K., Fahlén, S., Hydbring, P., Söderberg, O., Grummt, I., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1225 · Cited by 471 · see citing works

Identification of CDK4 as a target of c-MYC

Hermeking, H., Rago, C., Schuhmacher, M., Li, Q., Barrett, J. F., Obaya, Á. J., O’Connell, B. C., Mateyak, M. K., Tam, W., Kohlhuber, F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050586197 · Cited by 471 · see citing works

An initial blueprint for myogenic differentiationPreprint

Blais, A., Tsikitis, M., Acosta‐Alvear, D., Sharan, R., Kluger, Y., & Dynlacht, B. D. (2005) · Genes & Development · doi:10.1101/gad.1281105 · Cited by 464 · see citing works

Myc pathways provoking cell suicide and cancer

Nilsson, J. A., & Cleveland, J. L. (2003) · Oncogene · doi:10.1038/sj.onc.1207261 · Cited by 462 · see citing works

The myc Oncogene: arvelouslomplex

Oster, S. K., Ho, C. S. W., Soucie, E. L., & Penn, L. Z. (2002) · Advances in cancer research · doi:10.1016/s0065-230x(02)84004-0 · Cited by 459 · see citing works

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

Eilers, M., Picard, D., Yamamoto, K. R., & Bishop, J. M. (1989) · Nature · doi:10.1038/340066a0 · Cited by 458 · see citing works

Ras Enhances Myc Protein Stability

Sears, R. C., Leone, G. W., DeGregori, J. V., & Nevins, J. R. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80308-1 · Cited by 454 · see citing works

Destruction of Myc by ubiquitin‐mediated proteolysis: cancer‐associated and transforming mutations stabilize Myc

Salghetti, S. E., Kim, S. Y., & Tansey, W. P. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.717 · Cited by 445 · see citing works

Myc and Max proteins possess distinct transcriptional activities

Kretzner, L., Blackwood, E. M., & Eisenman, R. N. (1992) · Nature · doi:10.1038/359426a0 · Cited by 445 · see citing works

Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.

Mateyak, M. K., Obaya, Á. J., Adachi, S., & Sedivy, J. M. (1997) · PubMed · Cited by 445 · see citing works

Myc represses transcription through recruitment of DNA methyltransferase corepressor

Brenner, C., Deplus, R., Mirjolet, C., Loriot, A. E., Viré, E. A., Smet, C. D., Gutiérrez, A., Danovi, D., Bernard, D., Boon, T., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600509 · Cited by 443 · see citing works

c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

D'Cruz, C., Gunther, E., Boxer, R. B., Hartman, J., Sintasath, L., Moody, S., Cox, J. D., Seung, H. I., Belka, G., Golant, A., et al. (2001) · Nature Medicine · doi:10.1038/84691 · Cited by 439 · see citing works

N‐myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

Boon, K., Caron, H. N., van Asperen, R., Valentijn, L. J., Hermus, M.-C., Sluis, P. V., Roobeek, I., Weis, I., Voûte, P. A., Schwab, M., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1383 · Cited by 439 · see citing works

Direct activation of RNA polymerase III transcription by c-Myc

Gomez-Roman, N., Grandori, C., Eisenman, R. N., & White, R. J. (2003) · Nature · doi:10.1038/nature01327 · Cited by 434 · see citing works

c-Myc regulates mammalian body size by controlling cell number but not cell size

Trumpp, A., Refaeli, Y., Óskarsson, T., Gasser, S., Murphy, M., Martin, G. R., & Bishop, J. M. (2001) · Nature · doi:10.1038/414768a · Cited by 434 · see citing works

Mechanisms of apoptosis by c-Myc

Prendergast, G. C. (1999) · Oncogene · doi:10.1038/sj.onc.1202727 · Cited by 430 · see citing works

Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes

Menssen, A., & Hermeking, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082005599 · Cited by 405 · see citing works

c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

Cheng, S., Davies, K. P., Yung, E., Beltran, R. J., Yu, J. C., & Kalpana, G. V. (1999) · Nature Genetics · doi:10.1038/8811 · Cited by 396 · see citing works

BIN1 is a novel MYC–interacting protein with features of a tumour suppressor

Sakamuro, D., Elliott, K. J., Wechsler-Reya, R., & Prendergast, G. C. (1996) · Nature Genetics · doi:10.1038/ng0996-69 · Cited by 387 · see citing works

Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

Grewal, S., Li, L., Orian, A., Eisenman, R. N., & Edgar, B. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1223 · Cited by 387 · see citing works

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor networkPreprint

Orian, A., van Steensel, B., Delrow, J. J., Bussemaker, H. J., Li, L., Sawado, T., Williams, E., Loo, L. W. M., Cowley, S. M., Yost, C., et al. (2003) · Genes & Development · doi:10.1101/gad.1066903 · Cited by 385 · see citing works

Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays

Kim, J.-W., Zeller, K. I., Wang, Y., Jegga, A. G., Aronow, B. J., O'Donnell, K. A., & Dang, C. V. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5923-5936.2004 · Cited by 371 · see citing works

Evolution of transcription factors and the gene regulatory network in Escherichia coli

Babu, M. M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg210 · Cited by 354 · see citing works

The transcriptional program of a human B cell line in response to Myc.

Schuhmacher, M., Kohlhuber, F., Hölzel, M., Kaiser, C., Burtscher, H., Jarsch, M., Bornkamm, G., Laux, G., Polack, A., Weidle, U., et al. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.2.397 · Cited by 344 · see citing works

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoterPreprint

Bouchard, C., Dittrich, O., Kiermaier, A. C., Dohmann, K., Menkel, A. R., Eilers, M., & Lüscher, B. (2001) · Genes & Development · doi:10.1101/gad.907901 · Cited by 335 · see citing works

Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2 , by c-MYC

Wu, K., Polack, A., & Dalla‐Favera, R. (1999) · Science · doi:10.1126/science.283.5402.676 · Cited by 328 · see citing works

THE MANY ROLES OF c-Myc IN APOPTOSIS

Thompson, E. B. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.575 · Cited by 328 · see citing works

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells

Xu, D., Popov, N., Hou, M., Wang, Q., Björkholm, M., Gruber, A., Menkel, A. R., & Arsenian‐Henriksson, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043198 · Cited by 324 · see citing works

Deconstructing Myc: Figure 1.Preprint

Eisenman, R. N. (2001) · Genes & Development · doi:10.1101/gad928101 · Cited by 319 · see citing works

The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation

Cole, M. D., & McMahon, S. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202748 · Cited by 314 · see citing works

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

Wu, S., Cetinkaya, C., Muñoz-Alonso, M. J., von der Lehr, N., Bahram, F., Beuger, V., Eilers, M., León, J., & Larsson, L. (2003) · Oncogene · doi:10.1038/sj.onc.1206145 · Cited by 314 · see citing works

Functional Network Analysis Reveals Extended Gliomagenesis Pathway Maps and Three Novel MYC-Interacting Genes in Human Gliomas

Bredel, M., Bredel, C., Juric, D., Harsh, G. R., Vogel, H. S., Recht, L. D., & Sikic, B. I. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1204 · Cited by 311 · see citing works

Analysis of genomic targets reveals complex functions of MYC

Patel, J. H., Loboda, A. P., Showe, M. K., Showe, L. C., & McMahon, S. B. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1393 · Cited by 306 · see citing works

Growth Factor-Induced Delayed Early Response Genes

Lanahan, A. A., Williams, J., Sanders, L. K., & Nathans, D. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.9.3919-3929.1992 · Cited by 301 · see citing works

A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.Preprint

Ayer, D. E., & Eisenman, R. N. (1993) · Genes & Development · doi:10.1101/gad.7.11.2110 · Cited by 293 · see citing works

Identification of c-myc responsive genes using rat cDNA microarray.

Guo, Q., Malek, R. L., Kim, H., Chiao, C., He, M., Ruffy, M., Sanka, K., Lee, N. H., Dang, C. V., & Liu, E. T. (2000) · PubMed · Cited by 265 · see citing works

Gene expression phenotypic models that predict the activity of oncogenic pathways

Huang, E. S., Ishida, S., Pittman, J. L., Dressman, H. K., Bild, A., Kloos, M. T., D’Amico, M., Pestell, R. G., West, M., & Nevins, J. R. (2003) · Nature Genetics · doi:10.1038/ng1167 · Cited by 263 · see citing works

Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter

Eberhardy, S. R., & Farnham, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207441200 · Cited by 259 · see citing works

A role for transcriptional repression of p21 CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest

Claassen, G. F., & Hann, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150006697 · Cited by 256 · see citing works

The yeast coexpression network has a small‐world, scale‐free architecture and can be explained by a simple model

van Noort, V., Snel, ‎., & Huynen, M. A. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400090 · Cited by 256 · see citing works

Genetic regulators of large-scale transcriptional signatures in cancer

Adler, A. S., Lin, M., Horlings, H. M., Nuyten, D. S. A., van de Vijver, M. J., & Chang, H. Y. (2006) · Nature Genetics · doi:10.1038/ng1752 · Cited by 231 · see citing works

A library of gene expression signatures to illuminate normal and pathological lymphoid biology

Shaffer, A. L., Wright, G. W., Yang, L., Powell, J. I., Ngo, V. N., Lamy, L., Lam, L. T., Davis, R. E., & Staudt, L. M. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00373.x · Cited by 228 · see citing works

A Large Scale Genetic Analysis of c-Myc-regulated Gene Expression Patterns

O’Connell, B. C., Cheung, A. F., Simkevich, C. P., Tam, W., Ren, X., Mateyak, M. K., & Sedivy, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210462200 · Cited by 227 · see citing works

Transformation of follicular lymphoma to diffuse large-cell lymphoma: Alternative patterns with increased or decreased expression of c - myc and its regulated genes

Lossos, I. S., Alizadeh, A. A., Diehn, M., Warnke, R. A., Thorstenson, Y. R., Oefner, P. J., Brown, P. O., Botstein, D., & Levy, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132253599 · Cited by 226 · see citing works

Hierarchical Phosphorylation at N-Terminal Transformation-Sensitive Sites in c-Myc Protein Is Regulated by Mitogens and in Mitosis

Lutterbach, B. A., & Hann, S. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5510 · Cited by 220 · see citing works

Transcriptional repression by Myc

Wanzel, M., Herold, S., & Eilers, M. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00003-5 · Cited by 216 · see citing works

c-Myc Mediates Activation of the cad Promoter via a Post-RNA Polymerase II Recruitment Mechanism

Eberhardy, S. R., & Farnham, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m109014200 · Cited by 215 · see citing works

An extended transcriptional regulatory network of Escherichia coli and analysis of its hierarchical structure and network motifs

Ma, H.-W. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh1009 · Cited by 212 · see citing works

The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation

Wonsey, D. R., Zeller, K. I., & Dang, C. V. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102523299 · Cited by 205 · see citing works

A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism

Nikiforov, M. A., Chandriani, S. J., O’Connell, B. C., Petrenko, O., Kotenko, I., Beavis, A. J., Sedivy, J. M., & Cole, M. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5793-5800.2002 · Cited by 201 · see citing works

MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation

Poortinga, G., Hannan, K., Snelling, H., Walkley, C. R., Jenkins, A., Sharkey, K., Wall, M., Brandenburger, Y., Palatsides, M., Pearson, R., et al. (2004) · EMBO Journal · doi:10.1038/sj.emboj.7600335 · Cited by 198 · see citing works

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

Frye, M., Gardner, C., Li, E. R., Arnold, I., & Watt, F. M. (2003) · Development · doi:10.1242/dev.00462 · Cited by 187 · see citing works

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

Kim, S., Li, Q., Dang, C. V., & Lee, L. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200372597 · Cited by 187 · see citing works

A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiationPreprint

Penn, B. H., Bergstrom, D. A., Dilworth, F. J., Bengal, E., & Tapscott, S. J. (2004) · Genes & Development · doi:10.1101/gad.1234304 · Cited by 184 · see citing works

Quantitative proteomic analysis of Myc oncoprotein function

Shiio, Y., Donohoe, S., Yi, E. C., Goodlett, D. R., Aebersold, R. H., & Eisenman, R. N. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf525 · Cited by 184 · see citing works

Analysis of Myc Bound Loci Identified by CpG Island Arrays Shows that Max Is Essential for Myc-Dependent Repression

Mao, D. Y. L., Watson, J. D., Yan, P. S., Baršytė-Lovejoy, D., Khosravi, F., Wong, W. W.-L., Farnham, P., Huang, T. H. ‐., & Penn, L. Z. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00297-5 · Cited by 183 · see citing works

A role for c-Myc in the regulation of ribosomal RNA processing

Schlosser, I. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg794 · Cited by 183 · see citing works

The Max Network Gone Mad

Baudino, T. A., & Cleveland, J. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.3.691-702.2001 · Cited by 182 · see citing works

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

Kanazawa, S., Soucek, L., Evan, G. I., Okamoto, T., & Peterlin, B. M. (2003) · Oncogene · doi:10.1038/sj.onc.1206800 · Cited by 181 · see citing works

New Myc-interacting proteins: a second Myc network emerges

Sakamuro, D., & Prendergast, G. C. (1999) · Oncogene · doi:10.1038/sj.onc.1202725 · Cited by 178 · see citing works

An E-Box-Mediated Increase in cad Transcription at the G1/S-Phase Boundary Is Suppressed by Inhibitory c-Myc Mutants

Miltenberger, R. J., Sukow, K. A., & Farnham, P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2527 · Cited by 172 · see citing works

dMyc is required for larval growth and endoreplication in Drosophila

Pierce, S. B., Yost, C., Britton, J. S., Loo, L. W. M., Flynn, E. M., Edgar, B. A., & Eisenman, R. N. (2004) · Development · doi:10.1242/dev.01108 · Cited by 163 · see citing works

Myc represses the growth arrest gene gadd45

Marhin, W. W., Chen, S., Facchini, L. M., Fornace, A. J., & Penn, L. Z. (1997) · Oncogene · doi:10.1038/sj.onc.1201138 · Cited by 152 · see citing works

Identifying Genes Regulated in a Myc-dependent Manner

Watson, J. D., Oster, S. K., Shago, M., Khosravi, F., & Penn, L. Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201493200 · Cited by 130 · see citing works

c-Myc Overexpression Uncouples DNA Replication from Mitosis

Li, Q., & Dang, C. V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5339 · Cited by 128 · see citing works

Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis

Greasley, P. J. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.2.446 · Cited by 126 · see citing works

Myc-mediated transformation: the repression connection

Claassen, G. F., & Hann, S. (1999) · Oncogene · doi:10.1038/sj.onc.1202747 · Cited by 125 · see citing works

Reconstructing MYC: Figure 1.Preprint

Levens, D. (2003) · Genes & Development · doi:10.1101/gad.1095203 · Cited by 125 · see citing works

Characterization of Nucleophosmin (B23) as a Myc Target by Scanning Chromatin Immunoprecipitation

Zeller, K. I., Haggerty, T. J., Barrett, J. F., Guo, Q. M., Wonsey, D. R., & Dang, C. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108506200 · Cited by 123 · see citing works

c-MYC apoptotic function is mediated by NRF-1 target genesPreprint

Morrish, F. M., Giedt, C. D., & Hockenbery, D. M. (2003) · Genes & Development · doi:10.1101/gad.1032503 · Cited by 123 · see citing works

Disentangling the MYC web

Levens, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102173199 · Cited by 120 · see citing works

Myc

Secombe, J., Pierce, S. B., & Eisenman, R. N. (2004) · Cell · doi:10.1016/s0092-8674(04)00336-8 · Cited by 110 · see citing works

Drosophila dMyc is required for ovary cell growth and endoreplication

Maines, J. Z., Stevens, L. M., Tong, X., & Stein, D. (2004) · Development · doi:10.1242/dev.00932 · Cited by 110 · see citing works

A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites

Haggerty, T. J., Zeller, K. I., Osthus, R. C., Wonsey, D. R., & Dang, C. V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931346100 · Cited by 106 · see citing works

Mechanism for the transcriptional repression by c-Myc on PDGF β-receptor

Izumi, H., Molander, C., Penn, L. Z., Ishisaki, A., Kohno, K., & Funa, K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.8.1533 · Cited by 102 · see citing works

Lack of Cyclin-Dependent Kinase 4 Inhibits c- myc Tumorigenic Activities in Epithelial Tissues

de Marval, P. L. M., Macias, E., Rounbehler, R. J., Siciński, P., Kiyokawa, H., Johnson, D. G., Conti, C. J., & Rodríguez‐Puebla, M. L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7538-7547.2004 · Cited by 100 · see citing works

Modulation of T‐lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1

Iritani, B. M., Delrow, J. J., Grandori, C., Gomez, I. G., Klacking, M., Carlos, L. S., & Eisenman, R. N. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf492 · Cited by 97 · see citing works

Myc represses transcription of the growth arrest gene gas1

Lee, T. C., Li, L., Philipson, L., & Ziff, E. B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.12886 · Cited by 89 · see citing works

Normal and c-Myc-promoted human keratinocyte differentiation both occur via a novel cell cycle involving cellular growth and endoreplication

Gandarillas, A., Davies, D. C., & Blanchard, J. (2000) · Oncogene · doi:10.1038/sj.onc.1203630 · Cited by 79 · see citing works

Overexpression of Myc Suppresses CCAAT Transcription Factor/Nuclear Factor 1-Dependent Promoters in Vivo

Yang, B.-S., Gilbert, J. D., & Freytag, S. O. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.3093 · Cited by 63 · see citing works

Transcriptional suppression of cellular gene expression by c-Myc.

Yang, B., Geddes, T. J., Pogulis, R. J., Crombrugghe, B. D., & Freytag, S. O. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.4.2291 · Cited by 62 · see citing works

A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts

Berns, K., Hijmans, E. M., Koh, E. Y., Daley, G. Q., & Bernards, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203639 · Cited by 60 · see citing works

c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism

Baršytė-Lovejoy, D., Mao, D. Y. L., & Penn, L. Z. (2004) · Oncogene · doi:10.1038/sj.onc.1207487 · Cited by 55 · see citing works

Identification of novel Myc target genes with a potential role in lymphomagenesis

Marinković, D. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh877 · Cited by 50 · see citing works

Targeting c-Myc-activated genes with a correlation method: Detection of global changes in large gene expression network dynamics

Remondini, D., O’Connell, B. C., Intrator, N., Sedivy, J. M., Neretti, N., Castellani, G., & Cooper, L. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502081102 · Cited by 50 · see citing works

Association of the decreased expression of alpha3beta1 integrin with the altered cell: environmental interactions and enhanced soft agar cloning ability of c-myc-overexpressing small cell lung cancer cells.

Barr, L. F., Campbell, S. E., Bochner, B. S., & Dang, C. V. (1998) · PubMed · Cited by 46 · see citing works

Transcriptional Regulation of Myelopoiesis

Friedman, A. D. (2002) · International Journal of Hematology · doi:10.1007/bf02982108 · Cited by 43 · see citing works

DNA-Binding Domain of Human c-Myc Produced in Escherichia coli

Dang, C. V., van Dam, H., Buckmire, M., & Lee, W. M. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.6.2477 · Cited by 39 · see citing works

Complementation of Myc-dependent cell proliferation by cDNA expression library screening

Nikiforov, M. A., Kotenko, I., Petrenko, O., Beavis, A. J., Valenick, L. V., Lemischka, I. R., & Cole, M. D. (2000) · Oncogene · doi:10.1038/sj.onc.1203880 · Cited by 34 · see citing works

In silico identification of transcriptional regulators associated with c-Myc

Elkon, R. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh816 · Cited by 29 · see citing works

Promoter-binding and repression of PDGFRB by c-Myc are separable activities

Mao, D. Y. L. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh669 · Cited by 28 · see citing works

Characterization of the Murine Nramp1 Promoter

Bowen, H., Lapham, A. S., Phillips, E. S., Yeung, I., Alter-Koltunoff, M., Levi, B.-Z., Perry, V. H., Mann, D. A., & Barton, C. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304301200 · Cited by 12 · see citing works

c-Myc represses the murine Nrampl promoter

Bowen, H., Biggs, T. E., Baker, S. T., Phillips, E. S., Perry, V. H., Mann, D. A., & Barton, C. H. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300774 · Cited by 12 · see citing works

MYC on the Path to Cancer

Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390 · see citing works

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · see citing works

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020 · see citing works

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Lin, C. Y., Lovén, J., Rahl, P. B., Paranal, R. M., Burge, C. B., Bradner, J. E., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.08.026 · Cited by 1,498 · see citing works

Reflecting on 25 years with MYC

Meyer, N., & Penn, L. Z. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2231 · Cited by 1,575 · see citing works

Metabolic requirements for the maintenance of self-renewing stem cells

Ito, K., & Suda, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3772 · Cited by 1,014 · see citing works

MYC as a regulator of ribosome biogenesis and protein synthesis

van Riggelen, J., Yetil, A., & Felsher, D. W. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2819 · Cited by 956 · see citing works

Links between metabolism and cancerPreprint

Dang, C. V. (2012) · Genes & Development · doi:10.1101/gad.189365.112 · Cited by 991 · see citing works

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

Dang, C. V., Le, A., & Gao, P. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0889 · Cited by 934 · see citing works

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

Kumagai, S., Koyama, S., Itahashi, K., Tanegashima, T., Lin, Y.-T., Togashi, Y., Kamada, T., Irie, T., Okumura, G., Kono, H., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.01.001 · Cited by 892 · see citing works

Targeting oncogenic Myc as a strategy for cancer treatment

Chen, H., Liu, H., & Qing, G. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-018-0008-7 · Cited by 806 · see citing works

IRF4 addiction in multiple myeloma

Shaffer, A. L., Emre, N. C. T., Lamy, L., Ngo, V. N., Wright, G., Xiao, W., Powell, J., Dave, S., Yu, X., Zhao, H., et al. (2008) · Nature · doi:10.1038/nature07064 · Cited by 730 · see citing works

Double-hit B-cell lymphomas

Aukema, S., Siebert, R., Schuuring, E. M. D., Imhoff, G. W. V., Kluin‐Nelemans, H. C., Boerma, E.-J. G., & Kluin, P. M. (2010) · Blood · doi:10.1182/blood-2010-09-297879 · Cited by 677 · see citing works

The interplay between MYC and HIF in cancer

Dang, C. V., Kim, J., Gao, P., & Yustein, J. T. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2274 · Cited by 614 · see citing works

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Bywater, M. J., Poortinga, G., Sanij, E., Hein, N., Peck, A., Cullinane, C. M., Wall, M., Cluse, L. A., Drygin, D., Anderes, K. L., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.019 · Cited by 561 · see citing works

MYC as a target for cancer treatment

Duffy, M. J., O’Grady, S., Tang, M., & Crown, J. P. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102154 · Cited by 524 · see citing works

Apoptotic signaling by c-MYC

Hoffman‐Liebermann, B., & Liebermann, D. A. (2008) · Oncogene · doi:10.1038/onc.2008.312 · Cited by 485 · see citing works

G‐Quadruplexes: Targets in Anticancer Drug Design

Ou, T., Lu, Y., Tan, J., Huang, Z., Wong, K., & Gu, L. (2008) · ChemMedChem · doi:10.1002/cmdc.200700300 · Cited by 482 · see citing works

Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

Han, H., Jain, A. D., Truica, M. I., Izquierdo-Ferrer, J., Anker, J. F., Lysy, B., Sagar, V., Luan, Y., Chalmers, Z. R., Unno, K., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.10.001 · Cited by 461 · see citing works

Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

Gurel, B., Iwata, T., Koh, C. M., Jenkins, R., Lan, F., Dang, C., Hicks, J., Morgan, J. D., Cornish, T. C., Sutcliffe, S., et al. (2008) · Modern Pathology · doi:10.1038/modpathol.2008.111 · Cited by 459 · see citing works

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

Zhang, X.-Y., Varthi, M., Sykes, S. M., Phillips, C., Warzecha, C., Zhu, W., Wyce, A., Thorne, A. W., Berger, S. L., & McMahon, S. B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.015 · Cited by 427 · see citing works

c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells

Wang, J., Wang, H., Li, Z., Wu, Q., Lathia, J. D., McLendon, R. E., Hjelmeland, A. B., & Rich, J. N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003769 · Cited by 425 · see citing works

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

Wu, C.-H., van Riggelen, J., Yetil, A., Fan, A. C., Bachireddy, P., & Felsher, D. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701953104 · Cited by 405 · see citing works

Promotion of direct reprogramming by transformation-deficient Myc

Nakagawa, M., Takizawa, N., Narita, M., Ichisaka, T., & Yamanaka, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009374107 · Cited by 403 · see citing works

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc

Madden, S. K., de Araujo, A. D., Gerhardt, M., Fairlie, D. P., & Mason, J. M. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01291-6 · Cited by 404 · see citing works

Cancer cell metabolism: implications for therapeutic targets

Jang, M., Kim, S. S., & Lee, J. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.85 · Cited by 398 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

MYC and Breast Cancer

Xu, J., Chen, Y., & Olopade, O. I. (2010) · Genes & Cancer · doi:10.1177/1947601910378691 · Cited by 384 · see citing works

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

Pelletier, J., Graff, J., Ruggero, D., & Sonenberg, N. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2789 · Cited by 367 · see citing works

Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells

Venturini, L., Battmer, K., Castoldi, M., Schultheis, B. S., Hochhaus, A., Muckenthaler, M. U., Ganser, A., Eder, M., & Scherr, M. (2007) · Blood · doi:10.1182/blood-2006-09-045104 · Cited by 353 · see citing works

MYC protein interactors in gene transcription and cancer

Lourenco, C., Resetca, D., Redel, C., Lin, P., MacDonald, A. S., Ciaccio, R., Kenney, T. M. G., Wei, Y., Andrews, D. W., Sunnerhagen, M., et al. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00367-9 · Cited by 341 · see citing works

Anchorage-independent cell growth signature identifies tumors with metastatic potential

Mori, S., Chang, J. T., Andrechek, E. R., Matsumura, N., Baba, T., Yao, G., Kim, J., Gatza, M. L., Murphy, S. K., & Nevins, J. R. (2009) · Oncogene · doi:10.1038/onc.2009.139 · Cited by 346 · see citing works

Integrated genomic characterization of IDH1-mutant glioma malignant progression

Bai, H., Harmancı, A. S., Erson-Omay, Z., Li, J., Coşkun, S., Simon, M., Krischek, B., Özduman, K., Omay, S. B., Sorensen, E. A., et al. (2015) · Nature Genetics · doi:10.1038/ng.3457 · Cited by 324 · see citing works

Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins

Uzdensky, A. B. (2019) · APOPTOSIS · doi:10.1007/s10495-019-01556-6 · Cited by 293 · see citing works

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

Pourdehnad, M., Truitt, M., Siddiqi, I. N., Ducker, G. S., Shokat, K. M., & Ruggero, D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310230110 · Cited by 288 · see citing works

The curious case of the tumour virus: 50 years of Burkitt's lymphoma

Thorley‐Lawson, D. A., & Allday, M. J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro2015 · Cited by 277 · see citing works

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

Menssen, A., Hydbring, P., Kapelle, K., Vervoorts, J., Diebold, J., Lüscher, B., Larsson, L., & Hermeking, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105304109 · Cited by 275 · see citing works

The Pathology and Genetics of Metastatic Pancreatic Cancer

Yachida, S., & Iacobuzio–Donahue, C. A. (2009) · Archives of Pathology & Laboratory Medicine · doi:10.5858/133.3.413 · Cited by 269 · see citing works

Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance

Mohammed, M. K., Shao, C. C., Wang, J., Wei, Q., Wang, X. W., Collier, Z. J., Tang, S., Liu, H., Zhang, F., Huang, J., et al. (2016) · Genes & Diseases · doi:10.1016/j.gendis.2015.12.004 · Cited by 260 · see citing works

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

Mannava, S., Grachtchouk, V., Wheeler, L. J., Im, M., Zhuang, D., Slavina, E. G., Mathews, C. K., Shewach, D. S., & Nikiforov, M. A. (2008) · Cell Cycle · doi:10.4161/cc.6390 · Cited by 257 · see citing works

Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma

Yang, F., Xue, X., Bi, J., Zheng, L., Zhi, K., Gu, Y., & Fang, G. (2012) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-012-1324-x · Cited by 257 · see citing works

The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia

Sánchez-Martín, M., & Ferrando, A. A. (2017) · Blood · doi:10.1182/blood-2016-09-692582 · Cited by 252 · see citing works

MYC Oncogene Contributions to Release of Cell Cycle Brakes

García-Gutiérrez, L., Delgado, M. D., & León, J. (2019) · Genes · doi:10.3390/genes10030244 · Cited by 249 · see citing works

The Current State of Chromatin Immunoprecipitation

Collas, P. (2010) · Molecular Biotechnology · doi:10.1007/s12033-009-9239-8 · Cited by 254 · see citing works

Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature

Poornima, P., Kumar, J. D., Zhao, Q., Blunder, M., & Efferth, T. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.06.018 · Cited by 252 · see citing works

Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC

Blandino, G., Valerio, M., Cioce, M., Mori, F., Casadei, L., Pulito, C., Sacconi, A., Biagioni, F., Cortese, G., Galanti, S., et al. (2012) · Nature Communications · doi:10.1038/ncomms1859 · Cited by 240 · see citing works

Alternative approaches to target Myc for cancer treatment

Wang, C., Zhang, J., Yin, J., Gan, Y., Xu, S., Gu, Y., & Huang, W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00500-y · Cited by 243 · see citing works

Emerging roles of Myc in stem cell biology and novel tumor therapies

Yoshida, G. J. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0835-y · Cited by 244 · see citing works

Genome-wide identification of post-translational modulators of transcription factor activity in human B cells

Wang, K., Saito, M., Bisikirska, B. C., Alvarez, M. J., Lim, W. K., Rajbhandari, P., Shen, Q. “., Nemenman, I. M., Basso, K., Margolin, A. A., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1563 · Cited by 237 · see citing works

Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer

Elbadawy, M., Usui, T., Yamawaki, H., & Sasaki, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092340 · Cited by 237 · see citing works

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

Hammoudeh, D. I., Follis, A. V., Prochownik, E. V., & Metallo, S. J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja900616b · Cited by 232 · see citing works

Long non‐coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c‐Myc mRNA stability

Yang, F., Xue, X., Zheng, L., Bi, J., Zhou, Y., Zhi, K., Gu, Y., & Fang, G. (2013) · FEBS Journal · doi:10.1111/febs.12625 · Cited by 231 · see citing works

Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma

Zeid, R., Lawlor, M. A., Poon, E., Reyes, J. M., Fulciniti, M., Lopez, M. A., Scott, T. G., Nabet, B., Erb, M. A., Winter, G. E., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0044-9 · Cited by 230 · see citing works

Roles of Werner syndrome protein in protection of genome integrity

Rossi, M. L., Ghosh, A., & Bohr, V. A. (2010) · DNA repair · doi:10.1016/j.dnarep.2009.12.011 · Cited by 227 · see citing works

Cancer Metabolism: Current Understanding and Therapies

Counihan, J. L., Grossman, E. A., & Nomura, D. K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00775 · Cited by 229 · see citing works

Therapeutic Strategies to Inhibit MYCPreprint

McKeown, M. R., & Bradner, J. E. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014266 · Cited by 226 · see citing works

Targeting the nucleolus for cancer intervention

Quin, J. E., Devlin, J. R., Cameron, D. P., Hannan, K. M., Pearson, R. B., & Hannan, R. D. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.12.009 · Cited by 224 · see citing works

Targeting mTOR and Metabolism in Cancer: Lessons and Innovations

Magaway, C., Kim, E., & Jacinto, E. (2019) · Cells · doi:10.3390/cells8121584 · Cited by 225 · see citing works

Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics

Sarosiek, K. A., Fraser, C. S., Muthalagu, N., Bhola, P. D., Chang, W., McBrayer, S. K., Cantlon, A., Fisch, S., Golomb‐Mello, G., Ryan, J. A., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.11.011 · Cited by 224 · see citing works

High grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma

Rosenthal, A. C., & Younes, A. (2016) · Blood Reviews · doi:10.1016/j.blre.2016.09.004 · Cited by 221 · see citing works

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy

Gupta, S., Roy, A., & Dwarakanath, B. S. R. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00068 · Cited by 218 · see citing works

Control of glutamine metabolism by the tumor suppressor Rb

Reynolds, M. R., Lane, A. N., Robertson, B., Kemp, S., Liu, Y., Hill, B. G., Dean, D. C., & Clem, B. F. (2014) · Oncogene · doi:10.1038/onc.2012.635 · Cited by 216 · see citing works

Gestational trophoblastic neoplasia—pathogenesis and potential therapeutic targets

Shih, I. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70204-8 · Cited by 213 · see citing works

Mammalian Target of Rapamycin: Discovery of Rapamycin Reveals a Signaling Pathway Important for Normal and Cancer Cell Growth

Gibbons, J. J., Abraham, R. T., & Yu, K. (2009) · Seminars in Oncology · doi:10.1053/j.seminoncol.2009.10.011 · Cited by 209 · see citing works

MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

Ahmadi, S. E., Rahimi, S., Zarandi, B., Chegeni, R., & Safa, M. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01111-4 · Cited by 211 · see citing works

Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications

Omole, A. E., & Fakoya, A. O. J. (2018) · PeerJ · doi:10.7717/peerj.4370 · Cited by 207 · see citing works

The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth

Gouw, A. M., Margulis, K., Liu, N. S., Raman, S. J., Mancuso, A., Toal, G. G., Tong, L., Mosley, A. R., Hsieh, A. L., Sullivan, D. K., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.012 · Cited by 195 · see citing works

The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues

Goetzman, E. S., & Prochownik, E. V. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00129 · Cited by 199 · see citing works

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Lopes, N., McIntyre, C., Martin, S., Raverdeau, M., Sumaria, N., Kohlgruber, A. C., Fiala, G. J., Agudelo, L. Z., Dyck, L., Kane, H., et al. (2021) · Nature Immunology · doi:10.1038/s41590-020-00848-3 · Cited by 199 · see citing works

Long noncoding RNAs: Novel insights into gastric cancer

Fang, X., Pan, H., Leng, R., & Ye, D. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.11.005 · Cited by 197 · see citing works

Emerging roles of deubiquitinases in cancer‐associated pathways

Sacco, J. J., Coulson, J. M., Clague, M. J., & Urbé, S. (2010) · IUBMB Life · doi:10.1002/iub.300 · Cited by 194 · see citing works

PDK1: At the crossroad of cancer signaling pathways

Gagliardi, P. A., Puliafito, A., & Primo, L. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.04.014 · Cited by 196 · see citing works

RNA polymerases I and III, non-coding RNAs and cancer

White, R. J. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.003 · Cited by 190 · see citing works

A unified model for the G1/S cell cycle transition

Hume, S., Dianov, G. L., & Ramadan, K. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1002 · Cited by 190 · see citing works

ERK activation drives intestinal tumorigenesis in Apcmin/+ mice

Lee, S. H., Hu, L., González-Navajas, J. M., Seo, G. S., Shen, C., Brick, J., Herdman, S., Varki, N. M., Corr, M., Lee, J., et al. (2010) · Nature Medicine · doi:10.1038/nm.2143 · Cited by 188 · see citing works

The Role of Myc-Induced Protein Synthesis in Cancer

Ruggero, D. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1970 · Cited by 186 · see citing works

Metabolic Plasticity in Chemotherapy Resistance

Desbats, M. A., Giacomini, I., Prayer‐Galetti, T., & Montopoli, M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00281 · Cited by 180 · see citing works

Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach

Chen, L., & Cui, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160922830 · Cited by 184 · see citing works

Advances in the understanding of MYC‐induced lymphomagenesis

Klapproth, K., & Wirth, T. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08159.x · Cited by 180 · see citing works

Myc Enforces Overexpression ofEZH2in Early Prostatic Neoplasia via Transcriptional and Post-transcriptional Mechanisms

Koh, C. M., Iwata, T., Zheng, Q., Bethel, C. R., Yegnasubramanian, S., & Marzo, A. M. D. (2011) · Oncotarget · doi:10.18632/oncotarget.327 · Cited by 181 · see citing works

Impact of MYC in regulation of tumor cell metabolism

Wahlström, T., & Arsenian‐Henriksson, M. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.07.004 · Cited by 176 · see citing works

Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress

Maya‐Mendoza, A., Ostráková, J., Košař, M., Hall, A., Dušková, P., Mistrík, M., Merchut‐Maya, J. M., Hodný, Z., Bártková, J., Christensen, C., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.11.001 · Cited by 170 · see citing works

The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects

Nguyen, L., Papenhausen, P. R., & Shao, H. (2017) · Genes · doi:10.3390/genes8040116 · Cited by 177 · see citing works

The Transcription Factor FOXM1 (Forkhead box M1)

Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 174 · see citing works

Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition

Nikiforov, M. A., Riblett, M., Tang, W. H. W., Grachtchouk, V., Zhuang, D., Fernández, Y., Verhaegen, M. E., Varambally, S., Chinnaiyan, A. M., Jakubowiak, A. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708380104 · Cited by 174 · see citing works

Connections between metabolism and epigenetics in cancers

Thakur, C., & Chen, F. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.06.006 · Cited by 172 · see citing works

c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle

Wang, H., Mannava, S., Grachtchouk, V., Zhuang, D., Soengas, M. S., Gudkov, A. V., Prochownik, E. V., & Nikiforov, M. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210823 · Cited by 174 · see citing works

‘Warburg effect’ controls tumor growth, bacterial, viral infections and immunity – Genetic deconstruction and therapeutic perspectives

Pouysségur, J., Marchiq, I., Parks, S. K., Durivault, J., Ždralević, M., & Vučetić, M. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.07.004 · Cited by 172 · see citing works

The MYCN oncogene and differentiation in neuroblastoma

Westermark, U., Wilhelm, M., Frenzel, A., & Arsenian‐Henriksson, M. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.08.001 · Cited by 171 · see citing works

USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer

Pan, J., Deng, Q., Jiang, C., Wang, X., Niu, T., Li, H., Chen, T., Jin, J., Pan, W., Cai, X., et al. (2014) · Oncogene · doi:10.1038/onc.2014.327 · Cited by 169 · see citing works

Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis

Baniwal, S. K., Khalid, O. S., Gabet, Y., Shah, R., Purcell, D. J., Mav, D., Kohn-Gabet, A. E., Shi, Y., Coetzee, G. A., & Frenkel, B. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-258 · Cited by 169 · see citing works

MAX Inactivation in Small Cell Lung Cancer Disrupts MYC–SWI/SNF Programs and Is Synthetic Lethal with BRG1

Romero, O. A., Torres-Diz, M., Pros, E., Savola, S. P., Gómez, A., Morán, S., Sáez, C., Iwakawa, R., Villanueva, A., Montuenga, L. M., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0799 · Cited by 164 · see citing works

c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry

Morrish, F. M., Isern, N., Sadı́lek, M., Jeffrey, M., & Hockenbery, D. M. (2009) · Oncogene · doi:10.1038/onc.2009.112 · Cited by 164 · see citing works

Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1α

Qing, G., Skuli, N., Mayes, P. A., Pawel, B., Martinez, D., Maris, J. M., & Simon, M. C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0740 · Cited by 157 · see citing works

Regulation ofMYCgene expression by aberrant Wnt/β-catenin signaling in colorectal cancer

Rennoll, S. A. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i4.290 · Cited by 162 · see citing works

Oncogenic regulation of tumor metabolic reprogramming

Tarrado‐Castellarnau, M., de Atauri, P., & Cascante, M. (2016) · Oncotarget · doi:10.18632/oncotarget.10911 · Cited by 159 · see citing works

Transcription-independent functions of MYC: regulation of translation and DNA replication

Cole, M. D., & Cowling, V. H. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2467 · Cited by 160 · see citing works

HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources

Lebeau, A., Bruyère, D., Roncarati, P., Peixoto, P., Hervouet, É., Cobraiville, G., Taminiau, B., Masson, M., Gallego, C., Mazzucchelli, G., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28724-8 · Cited by 160 · see citing works

AP4 encodes a c-MYC-inducible repressor of p21

Jung, P., Menssen, A., Mayr, D. C., & Hermeking, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801773105 · Cited by 153 · see citing works

MYC in breast tumor progression

Chen, Y.-H., & Olopade, O. (2008) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.8.10.1689 · Cited by 155 · see citing works

Identifying Genes Regulated in a Myc-dependent Manner

Watson, J. D., Oster, S. K., Shago, M., Khosravi, F., & Penn, L. Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201493200 · Cited by 130 · see citing works

A Large Scale Genetic Analysis of c-Myc-regulated Gene Expression Patterns

O’Connell, B. C., Cheung, A. F., Simkevich, C. P., Tam, W., Ren, X., Mateyak, M. K., & Sedivy, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210462200 · Cited by 227 · see citing works

The MYC Network and Cancer

Thorgeirsson, S. S., & Factor, V. M. (2009) · Springer eBooks · doi:10.1007/978-3-642-00150-5_24 · Cited by 1 · see citing works

A Functional Hierarchy for c-Myc Target Genes? Lessons from MT-MC1

Cohen, D. E., & Prochownik, E. V. (2006) · Cell Cycle · doi:10.4161/cc.5.4.2484 · Cited by 7 · see citing works

Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters

Yap, C.-S., Peterson, A. L., Castellani, G., Sedivy, J. M., & Neretti, N. (2011) · Cell Cycle · doi:10.4161/cc.10.13.16249 · Cited by 41 · see citing works