The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus
Open accessAbstract
Upon cellular DNA damage, the p53 tumor suppressor protein transmits a signal to genes that control the cell cycle and apoptosis. One function of p53 that is important for its role in this pathway is its ability to function as a sequence-specific transcriptional activator. We demonstrate here that short single DNA strands can markedly stimulate the ability of human and murine p53 proteins to bind specifically to a p53 response element in supercoiled DNA. We also show that single-stranded DNA does not stimulate binding by a truncated p53 that lacks the C-terminal domain. Finally, we establish that a peptide spanning the p53 C-terminus has the ability in trans to stimulate sequence-specific DNA binding by p53 dramatically. These data taken together suggest a model in which the p53 C-terminus can recognize DNA structures resulting from damage-induced lesions, and this interaction can be propagated to regulate positively p53 sequence-specific DNA binding.
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Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,551 · cited 10×
“The experiments described above suggested that the p53 C-terminus, through its interactions with short single strands, may be capable of increasing the~affinity of the i ?, ~ .... 4 2 3 4 i~ i i~i iii i 1 2 3 4 Figure 2. central sequence-specific DNA-binding domain with a cognate site.”
BackgroundInfluentialCyclin G is a transcriptional target of the p53 tumor suppressor protein.
Okamoto, K., & Beach, D. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06807.x · Cited by 455
Cited by
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559
p53 mutant mice that display early ageing-associated phenotypes
Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459
The complexity of p53 modulation: emerging patterns from divergent signals
Giaccia, A. J., & Kastan, M. B. (1998) · Genes & Development · doi:10.1101/gad.12.19.2973 · Cited by 1,314
Life, death, and the pursuit of apoptosis.
White, E. (1996) · Genes & Development · doi:10.1101/gad.10.1.1 · Cited by 1,311
Metadata
- Authors
- Jayaraman, L., & Prives, C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 81
- Issue
- 7
- Pages
- 1021-1029
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2096079439
- Cited by
- 345
- References
- 3
- FWCI
- 18.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jayaraman, L., & Prives, C. (1995). Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus. Cell. https://doi.org/10.1016/s0092-8674(05)80007-8
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