The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Proteomics: new perspectives, new biomedical opportunities
Open accessAbstract
Proteomics-based approaches, which examine the expressed proteins of a tissue or cell type, complement the genome initiatives and are increasingly being used to address biomedical questions. Proteins are the main functional output, and the genetic code cannot always indicate which proteins are expressed, in what quantity, and in what form. For example, post-translational modifications of proteins, such as phosphorylation or glycosylation, are very important in determining protein function. Similarly, the effects of environmental factors or multigenic processes such as ageing or disease cannot be assessed simply by examination of the genome alone. This review describes the underlying technology and illustrates several areas of biomedical research, ranging from pathogenesis of neurological disorders to drug and vaccine design, in which potential clinical applications are being explored.
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Cites
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Cited by
Protein Analysis by Shotgun/Bottom-up Proteomics
Zhang, Y., Fonslow, B. R., Shan, B., Baek, M.-C., & Yates, J. R. (2013) · Chemical Reviews · doi:10.1021/cr3003533 · Cited by 1,491
Chromosomal stability and the DNA double-stranded break connection
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Generalist Genes and Learning Disabilities.
Plomin, R., & Kovas, Y. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.4.592 · Cited by 534
Multiplex in vitro detection using SERS
Laing, S., Gracie, K., & Faulds, K. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00644a · Cited by 361
Corbett, B. A., Kantor, A. B., Schulman, H., Walker, W. L., Lit, L., Ashwood, P., Rocke, D. M., & Sharp, F. R. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001943 · Cited by 197
Metadata
- Authors
- Banks, R. E., Dunn, M. J., Hochstrasser, D. F., Sanchez, J.-C., Blackstock, W., Pappin, D. J., & Selby, P. J.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2000-11
- Volume
- 356
- Issue
- 9243
- Pages
- 1749-1756
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2161768644
- Cited by
- 451
- References
- 6
- FWCI
- 19.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Banks, R. E., Dunn, M. J., Hochstrasser, D. F., Sanchez, J.-C., Blackstock, W., Pappin, D. J., & Selby, P. J. (2000). Proteomics: new perspectives, new biomedical opportunities. The Lancet. https://doi.org/10.1016/s0140-6736(00)03214-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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