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Cited by 470Growth Hormone and Insulin-like Growth FactorsDiabetes, Cardiovascular Risks, and LipoproteinsBirth, Development, and Health

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study

Sandhu, Manjinder S, Heald, Adrian H, Gibson, J Martin, Cruickshank, J Kennedy, Dunger, David B, Wareham, Nicholas J·2002·The Lancet
DOI 10.1016/s0140-6736(02)08655-5
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Abstract

Background Results of experimental and clinical studies suggest that insulin-like growth factor-I (IGF-I) and IGF binding protein-1 (IGFBP-1) could be important determinants of glucose homoeostasis. However, experimental models might also reflect compensatory and adaptive metabolic processes. We therefore prospectively examined the associations between circulating concentrations of IGF-I and IGFBP-1 and development of glucose tolerance.Methods Participants in this cohort study were a random sample of 615 normoglycaemic men and women aged 45-65 years. Participants underwent oral glucose tolerance testing based on WHO definitions and criteria in 1990-92 and 1994-96. At the baseline visit, we measured serum concentrations of IGF-I and IGFBP-1, and assessed the relation between these peptides and subsequent glucose intolerance.Findings At 4.5 years of follow-up, 51 (8%) of 615 participants developed impaired glucose tolerance or type-2 diabetes. After adjustment for correlates of IGF-I and risk factors for glucose intolerance, the odds ratio for risk of impaired glucose tolerance or type-2 diabetes for participants with IGF-I concentrations above the median (> or = 152 microg/L) compared with those with concentrations below the median (<152 microg/L) was 0.50 (0.26-0.95). Consistent with this finding, IGF-I also showed a significant inverse association with subsequent 2-h glucose concentrations, which was independent of correlates of IGF-I and risk factors for glucose tolerance (p for linear trend=0.026). We also found that this inverse association was independently modified by IGFBP-1 (p for interaction=0.011).Interpretation These data show that circulating IGF-I and its interaction with IGFBP-1 could be important determinants of glucose homoeostasis and provide further evidence for the possible protective role of IGF-I against development of glucose intolerance.

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Research works printed but not linked: 2

  1. 1996, Evidence from a dose ranging study that recombinant insulin-like growth factor-I effectively and safely improves glycaemic control in non-insulin dependent diabetes mellitus, Diabetes, 45, 27A
  2. Vaessen N. Population-based evidence for genetically programmed failure of the beta-cell in type 2 diabetes. In: Genetic determinants of diabetes and vascular complications, PhD thesis, Rotterdam, the Netherlands, 2001.

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Metadata

Authors
Sandhu, M. S., Heald, A. H., Gibson, J. M., Cruickshank, J. K., Dunger, D. B., & Wareham, N. J.
Affiliations
  • University of Cambridge (GB)
  • University of Manchester (GB)
Corresponding author
Wareham, Nicholas J
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
2002-05
Volume
359
Issue
9319
Pages
1740-1745
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(02)08655-5
OpenAlex
W2140997600
Cited by
470
References
33
Citations by year
2026: 3 · 2025: 10 · 2024: 11 · 2023: 13 · 2022: 18 · 2021: 15 · 2020: 17 · 2019: 15 · 2018: 18 · 2017: 18 · 2016: 17 · 2015: 14 · 2014: 19 · 2013: 11 · 2012: 28
FWCI
15.22
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
insulin-like growth factor I, IGF-binding protein-1, impaired glucose tolerance, type 2 diabetes, glucose homeostasis, 2-hour plasma glucose, middle-aged adults
MeSH terms
Aged, Blood Glucose, Fasting, Female, Homeostasis, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, Prospective Studies, Glucose Intolerance, Insulin-Like Growth Factor Binding Protein 1

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